Oxygen Tension in Human Malignant Disease under Hyperbaric Conditions

IT has been shown (Jamieson and van den Brenk, 1963a) that when Yoshida sarcoma was grown as solid tumour in rats and the animals were placed in oxygen at pressures raised to 4 atmospheres absolute there was a rapid rise in oxygen tension in both the normal tissues and the tumour. A polarographic technique was used to measure oxygen tension. In the present study similar measurements have been made of oxygen tension in spontaneous tumours and normal tissues of human patients treated with megavoltage irradiation during their exposure to hyperbaric oxygen. The polarographic technique and the pressure vessel used in these clinical studies have been described previously (Jamieson, 1962; van den Brenk, 1961). Tumour oxygen tension values are of general interest in the study and treatment of neoplastic growth but particularly in relation to the " oxygen effect " in radiosensitivity. Some doubt still exists whether high concentrations of the respired oxygen raise the oxygen tension in large tumours sufficiently to increase their radiosensitivity. Direct measurement of tumour oxygen tensions in vivo under high pressure oxygen exposure in man have been made by Evans and Naylor (1963). Our own studies present further data which have been analysed with a view to assessing the value of the polarographic technique for measurement of tumour PO2 in vivo.

• Publication year

  1965

• Venue

  British Journal of Cancer

• Publication date

  1965-03-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1038/bjc.1965.16PMID 14284375PMCID 2071413
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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