Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of dermatology (Print)

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1346-8138.2007.00304.xPMID 17584317
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Allergic contact dermatitis.

  2008cited by this paper
• Impaired contact hypersensitivity reaction and reduced production of vascular endothelial growth factor in tumor necrosis factor-α gene-deficient mice

  2005cited by this paper
• Impaired Contact Hypersensitivity Reaction and Reduced Production of Vascular Endothelial Growth Factor in Tumor Necrosis Factor‐α Gene‐Deficient Mice

  2005cited by this paper
• Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.

  2005cited by this paper
• Anti‐vascular endothelial growth factor receptor‐2 (Flk‐1/KDR) antibody suppresses contact hypersensitivity

  2004cited by this paper
• Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia.

  2004cited by this paper
• VEGF receptor signal transduction.

  2003cited by this paper
• A critical role of placental growth factor in the induction of inflammation and edema formation.

  2003cited by this paper
• E-mail Alert

  2003cited by this paper
• Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1

  2002cited by this paper
• Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin‐1β

  2002cited by this paper
• PTK 787 / ZK 222584 , a Specific Vascular Endothelial Growth Factor-Receptor Tyrosine Kinase Inhibitor , Affects the Anatomy of the Tumor Vascular Bed and the Functional Vascular Properties as Detected by Dynamic Enhanced Magnetic Resonance Imaging 1

  2002cited by this paper
• Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice.

  2002cited by this paper
• PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging.

  2002cited by this paper
• Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.

  2002cited by this paper
• Review: Contact Hypersensitivity: The Mechanism of Immune Responses and T Cell Balance

  2002cited by this paper
• Relationship between expression of matrix metalloproteinases and migration of epidermal and in vitro generated Langerhans cells.

  2002cited by this paper
• IL‐4 and interferon‐γ differentially modulate vascular endothelial growth factor release from normal human keratinocytes and fibroblasts

  2002cited by this paper
• Skin Inflammation During Contact Hypersensitivity Is Mediated by Early Recruitment of CD8+ T Cytotoxic 1 Cells Inducing Keratinocyte Apoptosis1

  2002cited by this paper
• Vascular endothelial growth factor (VEGF) induces human Langerhans cell migration

  2001cited by this paper
• Topically applied lactic acid increases spontaneous secretion of vascular endothelial growth factor by human reconstructed epidermis

  2001cited by this paper
• Mechanisms of angiogenesis and arteriogenesis

  2000cited by this paper
• Accessory cell populations in draining lymph nodes of lambs in the elicitation phase of DNCB-induced contact hypersensitivity.

  2000cited by this paper
• Inhibition of vascular endothelial growth factor (VEGF) as a novel approach for cancer therapy.

  2000cited by this paper
• Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization.

  2000cited by this paper
• PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

  2000cited by this paper
• The role of VEGF and thrombospondins in skin angiogenesis.

  2000cited by this paper
• VEGF is major stimulator in model of choroidal neovascularization.

  2000cited by this paper
• PTK 787 / ZK 222584 , a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases , Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration

  2000cited by this paper
• Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA

  1999cited by this paper
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

  1998cited by this paper
• Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.

  1998cited by this paper
• Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.

  1997cited by this paper
• Neovasculature induced by vascular endothelial growth factor is fenestrated.

  1997cited by this paper
• Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.

  1997cited by this paper
• T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells

  1996cited by this paper
• Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.

  1996cited by this paper
• The vesiculo‐vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation

  1996cited by this paper
• Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.

  1995cited by this paper
• Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression.

  1995cited by this paper
• Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions.

  1995cited by this paper
• Angiogenesis and endothelial cell function.

  1994cited by this paper
• The Interaction between Langerhans Cells and CD4+ T Cells

  1992cited by this paper
• The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells

  1992cited by this paper
• Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

  1992cited by this paper
• Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.

  1990cited by this paper
• Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

  1990cited by this paper
• Heated laser Doppler flow measurements to determine depth of burn injury.

  1989cited by this paper
• Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies

  1987cited by this paper
• Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice.

  1984cited by this paper
• Lessons learnt from 2,409 burn patients operated by early excision.

  1979cited by this paper
• Tumor angiogenesis: therapeutic implications.

  1971cited by this paper
• Transplacental carcinogenesis by stilbestrol.

  1971cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• The omega-3 postbiotic trans-10-cis-15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A

  2024cites this paper
• Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.

  2016cites this paper
• Precision Subtypes of T Cell-Mediated Rejection Identified by Molecular Profiles

  2015cites this paper
• Angiogenesis and lymphangiogenesis in inflammatory skin disorders.

  2015cites this paper
• Drugs used to treat Parkinson's disease, present status and future directions.

  2008cites this paper
• Endothelial activation and dysregulation: A common pathway to organ injury in infectious diseases associated with systemic inflammation

  2007cites this paper