The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cancer Epidemiology, Biomarkers and Prevention

• Publication date

  2008-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1055-9965.EPI-07-0658PMID 18268112PMCID PMC2515594
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention

  2007cited by this paper
• Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

  2007cited by this paper
• Predictors of mortality after androgen‐deprivation therapy in patients with rapidly rising prostate‐specific antigen levels after local therapy for prostate cancer

  2006cited by this paper
• Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.

  2006cited by this paper
• A Comprehensive Strategy to Combat Colon Cancer Targeting the Adenomatous Polyposis Coli Tumor Suppressor Gene

  2005cited by this paper
• Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment.

  2005cited by this paper
• Pretreatment predictors of posttreatment PSA doubling times for patients undergoing three-dimensional conformal radiotherapy for clinically localized prostate cancer.

  2005cited by this paper
• Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3.

  2005cited by this paper
• Predictors of prostate cancer-specific mortality after radical prostatectomy or radiation therapy.

  2005cited by this paper
• A Randomized , Placebo-controlled Trial of Low-Dose a-Difluoromethylornithine in Individuals at Risk for Colorectal Cancer ’

  2005cited by this paper
• Association among an ornithine decarboxylase polymorphism, androgen receptor gene (CAG) repeat length and prostate cancer risk.

  2004cited by this paper
• Polyamines as clinical laboratory tools.

  2004cited by this paper
• Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groups

  2004cited by this paper
• Selenium and Vitamin E Cancer Prevention Trial

  2004cited by this paper
• Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial.

  2004cited by this paper
• Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice*

  2004cited by this paper
• Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival

  2004cited by this paper
• Pathological and molecular mechanisms of prostate carcinogenesis: Implications for diagnosis, detection, prevention, and treatment

  2004influential reference
• Polyamines and cancer: old molecules, new understanding

  2004cited by this paper
• The influence of finasteride on the development of prostate cancer.

  2003cited by this paper
• Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas.

  2003cited by this paper
• Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

  2003cited by this paper
• Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.

  2002cited by this paper
• The ageing male: demographics and challenges

  2002cited by this paper
• A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.

  2002cited by this paper
• Chemoprevention of Prostate Carcinogenesis by DFMO and/or Finasteride Treatment in Male Wistar Rats

  2002cited by this paper
• Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.

  2001cited by this paper
• SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial.

  2001cited by this paper
• Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions.

  2001cited by this paper
• SELECT: THE NEXT PROSTATE CANCER PREVENTION TRIAL

  2001cited by this paper
• Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme.

  2001cited by this paper
• Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.

  2000cited by this paper
• Chemoprevention of prostate carcinogenesis by α-difluoromethylornithine in TRAMP mice

  2000cited by this paper
• Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine.

  2000cited by this paper
• Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme.

  2000cited by this paper
• A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer.

  1998cited by this paper
• Effect of (cid:97) -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention

  1998cited by this paper
• Cell transformation, invasion, and angiogenesis: a regulatory role for ornithine decarboxylase and polyamines?

  1997cited by this paper
• Androgen regulation of ornithine decarboxylase in human prostatic cells identified using differential display

  1997cited by this paper
• Polyamines in the male reproductive system.

  1996cited by this paper
• Toxicity evaluation of difluoromethylornithine: doses for chemoprevention trials.

  1996cited by this paper
• Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine.

  1994cited by this paper
• Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps.

  1994cited by this paper
• Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa.

  1993cited by this paper
• Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges.

  1993cited by this paper
• Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine.

  1992cited by this paper
• The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.

  1991cited by this paper
• Statistical Intervals: A Guide for Practitioners

  1991cited by this paper
• Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.

  1990cited by this paper
• Polyamines in normal and cancer cells.

  1987cited by this paper
• The development of human benign prostatic hyperplasia with age.

  1984cited by this paper
• Copenhagen rat prostatic tumor ornithine decarboxylase activity (ODC) and the effect of the ODC inhibitor alpha‐difluoromethylornithine

  1982cited by this paper
• High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives.

  1980cited by this paper
• Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues.

  1979cited by this paper
• Effects of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats.

  1979cited by this paper
• Altered polyamine profiles in prostatic hyperplasia and in kidney tumors.

  1978cited by this paper

• A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression.

  2026cites this paper
• Polyamines buffer labile iron to suppress ferroptosis

  2025cites this paper
• Preclinical evaluation of the efficacy of α−Difluoromethylornithine and Sulindac against SARS-CoV-2 infection

  2025cites this paper
• Preclinical Evaluation of the Efficacy of α-Difluoromethylornithine and Sulindac Against SARS-CoV-2 Infection

  2025cites this paper
• Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

  2025cites this paper
• Polyamine metabolism in prostate cancer

  2025cites this paper
• Polyamine depletion limits progression of acute leukaemia

  2025cites this paper
• Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

  2025cites this paper
• Construction of Metastasis Prediction Models and Screening of Anti-Metastatic Drugs Based on Pan-Cancer Single-Cell EMT Features

  2025cites this paper
• The Polyamine–Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma

  2023cites this paper
• Polyamines in cancer: integrating organismal metabolism and antitumour immunity

  2022cites this paper
• Arm race between Rift Valley fever virus and host

  2022cites this paper
• 3,3'-Diindolylmethane plus Eflornithine suppress DNA Replication and Cell Cycle in Esophageal Squamous Cell Carcinoma in vivo

  2022cites this paper
• Ototoxicity Review: A Growing Number of Non-Platinum-Based Chemo- and Immunotherapies.

  2022cites this paper
• Antizyme Inhibitor 1 regulates matrikine expression and enhances the metastatic potential of aggressive primary prostate cancer.

  2022cites this paper
• The Emerging Clinical Role of Spermine in Prostate Cancer

  2021influential citation
• Polyamine Analog Diethylnorspermidine Restricts Coxsackievirus B3 and Is Overcome by 2A Protease Mutation In Vitro

  2021cites this paper
• Radiosynthesis and evaluation of N5-(2-18F-fluoropropanyl) ornithine as a potential agent for tumor PET imaging.

  2021cites this paper
• NSAIDs: Old Acquaintance in the Pipeline for Cancer Treatment and Prevention─Structural Modulation, Mechanisms of Action, and Bright Future.

  2021cites this paper
• Protective Role of Spermidine in Colitis and Colon Carcinogenesis.

  2021cites this paper
• Spermidine as a target for cancer therapy.

  2020cites this paper
• Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO

  2020cites this paper
• Divergent regulation of the key enzymes of polyamine metabolism by chiral (cid:11) -methylated polyamine analogs

  2020cites this paper
• Dissecting a Role for Polyamines in Rift Valley Fever Virus Infection

  2020cites this paper
• Untargeted Metabolomics and Polyamine Profiling in Serum before and after Surgery in Colorectal Cancer Patients

  2020cites this paper
• Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways

  2020cites this paper
• PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness.

  2019cites this paper
• Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

  2019cites this paper
• Polyamine Depletion Inhibits Bunyavirus Infection via Generation of Noninfectious Interfering Virions

  2019cites this paper
• Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity

  2019cites this paper
• Multiple markers for the non-invasive diagnosis and characterisation of prostate cancer

  2017cites this paper
• Difluoromethylornithine in cancer: new advances.

  2017cites this paper
• Ornithine decarboxylase as a therapeutic target for endometrial cancer

  2017cites this paper
• Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.

  2016cites this paper
• Benign prostatic hyperplasia

  2016cites this paper
• One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

  2016influential citation
• Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.

  2016cites this paper
• Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice.

  2016cites this paper
• Chemoprevention agents for prostate cancer

  2016cites this paper
• Prevention and early detection of prostate cancer.

  2014cites this paper
• Epibrassinolide‐induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells

  2014cites this paper
• [The importance of putrescine in the human body].

  2014cites this paper
• NMR-based metabolomics: global analysis of metabolites to address problems in prostate cancer

  2014cites this paper
• The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.

  2014cites this paper
• Polyamines are oncometabolites that regulate the LIN28/let‐7 pathway in colorectal cancer cells

  2014cites this paper
• Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling

  2014influential citation
• Polyamines metabolism and breast cancer: state of the art and perspectives

  2014cites this paper
• Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine.

  2014cites this paper
• Prostate cancer prevention: agent development strategies.

  2014cites this paper
• Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats

  2014cites this paper
• Prevention and early detection of prostate cancer

  2014cites this paper
• Managing conditions of the prostate gland in primary care

  2013cites this paper
• MOLECULAR AND FUNCTIONAL CONSEQUENCES OF GENETIC VARIABILITY IN THE ORNITHINE DECARBOXYLASE GENE IN COLORECTAL CANCER

  2013cites this paper
• Enhanced evaluation of selective androgen receptor modulators in vivo

  2013cites this paper
• Polyamines and cancer: implications for chemotherapy and chemoprevention

  2013cites this paper
• [Pharmaco and diet based prostate cancer prevention].

  2013cites this paper
• Comparative effects of difluoromethylornithine and siberian ginseng root tincture on radiation-induced carcinogenesis in rats and their lifespan

  2013cites this paper
• Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer

  2012cites this paper
• A Phase III Skin Cancer Chemoprevention Study of DFMO: Long-term Follow-up of Skin Cancer Events and Toxicity

  2012cites this paper
• Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.

  2012cites this paper
• Difluoromethylornithine: The Proof Is in the Polyamines

  2012cites this paper
• Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells.

  2012cites this paper
• Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

  2012cites this paper
• Genes in Stroma Diagnosis of Prostate Cancer Using Differentially Expressed

  2011cites this paper
• Targeting polyamines and inflammation for cancer prevention.

  2011cites this paper
• Cellular diamine levels in cancer chemoprevention: modulation by ibuprofen and membrane plasmalogens

  2011cites this paper
• DFMO: targeted risk reduction therapy for colorectal neoplasia.

  2011cites this paper
• The polyamine pathway as a potential target for vascular diseases: focus on restenosis.

  2011cites this paper
• Current status of the polyamine research field.

  2011cites this paper
• Assessing prostate cancer growth with mRNA of spermine metabolic enzymes

  2010cites this paper
• Diagnosis of prostate cancer using differentially expressed genes in stroma.

  2010cites this paper
• Cancer Chemoprevention Locks onto a New Polyamine Metabolic Target

  2010cites this paper
• The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

  2010cites this paper
• Myc-induced Lymphomagenesis In vivo assessment of downstream pathways

  2010cites this paper
• Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase*

  2010cites this paper
• Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals

  2010cites this paper
• Prostate Cancer Chemoprevention Strategies

  2010cites this paper
• Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach

  2010cites this paper
• Spermine metabolism and anticancer therapy.

  2009cites this paper
• Emerging drugs for prostate cancer

  2009cites this paper
• Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.

  2009cites this paper
• Spermine Synthase Deficiency Leads to Deafness and a Profound Sensitivity to α-Difluoromethylornithine*♦

  2009cites this paper
• Associations of a Polymorphism in the Ornithine Decarboxylase Gene with Colorectal Cancer Survival

  2009cites this paper
• Design of polyamine-based therapeutic agents: new targets and new directions.

  2009cites this paper
• Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

  2009cites this paper
• Recent advances in the development of polyamine analogues as antitumor agents.

  2009cites this paper
• A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

  2009cites this paper
• Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047.

  2009cites this paper
• Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.

  2009cites this paper
• Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma

  2008cites this paper