Lunasin: A Novel Cancer Preventive Seed Peptide

Cancer is one of the leading causes of deaths in the Western world. Approximately one-third of these deaths are preventable by lifestyle factors, including modification of nutritional habits. Studies have demonstrated that adequate nutrition with certain types of foods containing bioactive compounds might offer significant protection against carcinogenesis. Soybeans contain a variety of phytochemicals with demonstrated anticancer activity, including isoflavones, protease inhibitors, and more recently lunasin, a novel cancer preventive seed peptide. Initially isolated from soybean, lunasin has also been reported in barley and wheat. The purpose of this review is to summarize the most recent evidence on the possible benefits of lunasin for cancer prevention.

• Publication year

  2008

• Venue

  Perspectives in Medicinal Chemistry

• Publication date

  2008-03-25

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.4137/PMC.S372PMID 19787099PMCID 2746573
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state.

  2004cited by this paper
• Lunasin concentration in different soybean genotypes, commercial soy protein, and isoflavone products.

  2004cited by this paper
• Characterization of lunasin isolated from soybean.

  2003cited by this paper
• Soy, isoflavones, and breast cancer risk in Japan.

  2003cited by this paper
• Soy and isoflavone consumption in relation to prostate cancer risk in China.

  2003cited by this paper
• Lunasin™ Suppresses E1A-Mediated Transformation of Mammalian Cells but Does Not Inhibit Growth of Immortalized and Established Cancer Cell Lines

  2003cited by this paper
• Development of the Bowman‐Birk inhibitor for oral cancer chemoprevention and analysis of neu immunohistochemical staining intensity with Bowman‐Birk inhibitor concentrate treatment

  2003cited by this paper
• Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shanghai.

  2002cited by this paper
• Effects of Bowman-Birk Inhibitor on Rat Colon Carcinogenesis

  2002cited by this paper
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  2002cited by this paper
• Effects of the Bowman‐Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells *

  2002cited by this paper
• Development of Bowman‐Birk Inhibitor for Chemoprevention of Oral Head and Neck Cancer

  2001cited by this paper
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  2001cited by this paper
• Single-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia.

  2000cited by this paper
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  2000cited by this paper
• Effects of the Bowman-Birk inhibitor on clonogenic survival and cisplatin- or radiation-induced cytotoxicity in human breast, cervical, and head and neck cancer cells.

  1999cited by this paper
• A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• The Electronic Plant Gene Register.

  1997cited by this paper
• Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor.

  1996cited by this paper
• Prevention of carcinogenesis by protease inhibitors.

  1994cited by this paper
• Protection against metastasis of radiation-induced thymic lymphosarcoma and weight loss in C57Bl/6NCr1BR mice by an autoclave-resistant factor present in soybeans.

  1992cited by this paper
• A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor.

  1992cited by this paper
• Inhibition of N-nitrosomethylbenzylamine-induced esophageal neoplasms by the Bowman-Birk protease inhibitor.

  1991cited by this paper
• The role of soy products in reducing risk of cancer.

  1991cited by this paper
• Suppression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk protease inhibitor.

  1990cited by this paper
• Modulation of lung tumor development in mice with the soybean-derived Bowman-Birk protease inhibitor.

  1989cited by this paper
• Inhibition of oral carcinogenesis by a protease inhibitor.

  1986cited by this paper
• Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro.

  1985cited by this paper

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2013cites this paper
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  2012cites this paper
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