Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Calsequestrin 2-Null Hearts

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Circulation: Arrhythmia and Electrophysiology

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCEP.113.000994PMID 24493699PMCID PMC3989424
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic mechanisms of atrial fibrillation: impact on response to treatment

  2013influential reference
• Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

  2012influential reference
• The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities.

  2012cited by this paper
• Calcium Leak Through Ryanodine Receptors Leads to Atrial Fibrillation in 3 Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia

  2012cited by this paper
• Mechanisms of Human Atrial Fibrillation Initiation: Clinical and Computational Studies of Repolarization Restitution and Activation Latency

  2012cited by this paper
• Phosphodiesterase-4 activity: a critical modulator of atrial contractility and arrhythmogenesis.

  2012cited by this paper
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  2011cited by this paper
• Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

  2011cited by this paper
• Inhibition of Cardiac Ca2+ Release Channels by Class I Anti Arrhythmic Drugs as Therapy for Arrhythmia

  2011cited by this paper
• Alterations of atrial Ca(2+) handling as cause and consequence of atrial fibrillation.

  2011cited by this paper
• Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.

  2011cited by this paper
• Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia

  2011cited by this paper
• So little source, so much sink: requirements for afterdepolarizations to propagate in tissue.

  2010cited by this paper
• Rough endoplasmic reticulum to junctional sarcoplasmic reticulum trafficking of calsequestrin in adult cardiomyocytes.

  2010cited by this paper
• CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

  2010influential reference
• Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

  2009cited by this paper
• Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

  2008cited by this paper
• Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

  2008cited by this paper
• Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia.

  2007influential reference
• Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia.

  2006cited by this paper
• Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation

  2006cited by this paper
• Casq 2 deletion causes sarcoplasmic reticulum volume increase , premature Ca 2 + release , and catecholaminergic polymorphic ventricular tachycardia

  2006cited by this paper
• Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

  2005cited by this paper
• Atrial Fibrillation Is Associated With Increased Spontaneous Calcium Release From the Sarcoplasmic Reticulum in Human Atrial Myocytes

  2004cited by this paper
• Outpatient treatment of recent-onset atrial fibrillation with the "pill-in-the-pocket" approach.

  2004cited by this paper
• Defective glycosylation of calsequestrin in heart failure.

  2004cited by this paper
• Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study

  2004cited by this paper
• Clinical and Molecular Characterization of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

  2002cited by this paper
• Effects of propafenone on K currents in human atrial myocytes

  1999cited by this paper
• Effects of propafenone on calcium currents in single ventricular myocytes of guinea‐pig

  1993cited by this paper
• Stereoselective disposition and pharmacologic activity of propafenone enantiomers.

  1989cited by this paper

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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• Emerging Antiarrhythmic Drugs for Atrial Fibrillation

  2022cites this paper
• Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals

  2022cites this paper
• Targeting the RyR (Ryanodine Receptor) to Prevent Atrial Fibrillation.

  2022cites this paper
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• Optimizing Transesophageal Atrial Pacing in Mice to Detect Atrial Fibrillation.

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• University of Birmingham High-throughput analysis of optical mapping data using Electromap

  2019cites this paper
• Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes

  2018cites this paper
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  2018cites this paper
• Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2R33Q/R33Q Mutation Mice

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• Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

  2018cites this paper
• Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia

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  2017influential citation
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  2017cites this paper
• Catecholaminergic Polymorphic Ventricular Tachycardia.

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  year unknowncites this paper
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  year unknowncites this paper
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