A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption—Part II: Gastrointestinal Transit Time

No abstract is available for this paper.

• Publication year

  2016

• Venue

  AAPS Journal

• Publication date

  2016-07-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1208/s12248-016-9953-7PMID 27439620
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Population In Vitro-In Vivo Correlation Model Linking Gastrointestinal Transit Time, pH, and Pharmacokinetics: Itraconazole as a Model Drug

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• Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions

  2016cited by this paper
• Assessment of Tandem Measurements of pH and Total Gut Transit Time in Healthy Volunteers

  2015cited by this paper
• Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets

  2015cited by this paper
• Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.

  2015cited by this paper
• Meta-Analysis Package for R

  2015cited by this paper
• R: A language and environment for statistical computing.

  2014cited by this paper
• PBPK models for the prediction of in vivo performance of oral dosage forms.

  2014cited by this paper
• Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range

  2014cited by this paper
• Designing a dynamic dissolution method: a review of instrumental options and corresponding physiology of stomach and small intestine.

  2013cited by this paper
• Effect of high fat-diet and obesity on gastrointestinal motility.

  2013cited by this paper
• A Semi-mechanistic Modeling Strategy to Link In Vitro and In Vivo Drug Release for Modified Release Formulations

  2012cited by this paper
• Location, location, location: gastrointestinal delivery site and its impact on absorption.

  2012cited by this paper
• Gastrointestinal pH profile in subjects with irritable bowel syndrome

  2012cited by this paper
• Applied Meta-Analysis for Social Science Research

  2011influential reference
• A Semi-mechanistic Modeling Strategy for Characterization of Regional Absorption Properties and Prospective Prediction of Plasma Concentrations Following Administration of New Modified Release Formulations

  2011cited by this paper
• Pernicious anemia - genetic insights.

  2011cited by this paper
• Gastric juice acidity in upper gastrointestinal diseases.

  2010cited by this paper
• Conducting Meta-Analyses in R with the metafor Package

  2010cited by this paper
• Meta-analysis of individual participant data: rationale, conduct, and reporting

  2010cited by this paper
• Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy.

  2010cited by this paper
• NONMEM User’s Guides. (1989–2009)

  2009cited by this paper
• Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine

  2009cited by this paper
• Gastric emptying of a non‐digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy

  2008cited by this paper
• Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.

  2008cited by this paper
• Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

  2008cited by this paper
• The influence of non‐disintegrating tablet dimensions and density on their gastric emptying in fasted volunteers

  2007cited by this paper
• Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies

  2006cited by this paper
• Regional Postprandial Differences in pH Within the Stomach and Gastroesophageal Junction

  2005cited by this paper
• Bias and Efficiency of Meta-Analytic Variance Estimators in the Random-Effects Model

  2005influential reference
• Impact of the intragastric location of extended release tablets on food interactions.

  2005cited by this paper
• Reduced oral itraconazole bioavailability by antacid suspension

  2005cited by this paper
• The effect of intermittent high-intensity running on gastric emptying of fluids in man.

  2005cited by this paper
• Mechanism of Gastric Emptying of a Nondisintegrating Radiotelemetry Capsule in Man

  2004cited by this paper
• Effect of postprandial posture on digestion and absorption of dietary carbohydrate.

  2002cited by this paper
• Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis.

  2001cited by this paper
• Gastric Emptying and Dyspeptic Symptoms in Patients with Nonautoimmune Fundic Atrophic Gastritis

  2000cited by this paper
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  2000cited by this paper
• Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery

  1999cited by this paper
• Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration

  1999cited by this paper
• Inflammation Does Not Decrease Intraluminal pH in Chronic Inflammatory Bowel Disease

  1999cited by this paper
• Meal Composition Effects on the Oral Bioavailability of Indinavir in HIV-Infected Patients

  1999cited by this paper
• Gastrointestinal pH profiles in patients with inflammatory bowel disease

  1998cited by this paper
• Small Intestinal Transit Time and Intraluminal pH in Ileocecal Resected Patients with Crohn's Disease

  1998cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women

  1997cited by this paper
• Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn's disease.

  1997cited by this paper
• Stability and Performance of a Population Pharmacokinetic Model

  1997cited by this paper
• Changes in parietal cell structure and function in HIV disease

  1996cited by this paper
• Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with the emphasis on colon

  1996influential reference
• The effect of food on the gastrointestinal transit and systemic absorption of naproxen from a novel sustained release formulation

  1995influential reference
• Comparative gastrointestinal transit of pellet systems of varying density

  1995cited by this paper
• Gastrointestinal transit of pellets of differing size and density

  1993cited by this paper
• Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation

  1993cited by this paper
• Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women

  1993cited by this paper
• Do pellet formulations empty from the stomach with food

  1993cited by this paper
• Meta-analysis of the literature or of individual patient data: is there a difference?

  1993cited by this paper
• Gastrointestinal Transit and Systemic Absorption of Captopril from a Pulsed-Release Formulation

  1992cited by this paper
• Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects

  1991cited by this paper
• Gastric emptying of indigestible tablets in relation to composition and time of ingestion of meals studied by metal detector

  1991cited by this paper
• Gastric emptying of nondigestible solids in dogs: a hydrodynamic correlation.

  1990cited by this paper
• Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women

  1990cited by this paper
• Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects

  1989cited by this paper
• Comparison of gastric body and antral pH: a 24 hour ambulatory study in healthy volunteers.

  1989cited by this paper
• pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device

  1989cited by this paper
• Gastrointestinal transit of non-disintegrating tablets in fed subjects

  1989cited by this paper
• Gastrointestinal Transit of a Solid Indigestible Capsule as Measured by Radiotelemetry and Dual Gamma Scintigraphy

  1989cited by this paper
• Measurement of gastrointestinal pH profiles in normal ambulant human subjects.

  1988cited by this paper
• 24-hour study of intragastric acidity in duodenal ulcer patients and normal subjects using continuous intraluminal pH-metry

  1988cited by this paper
• Gastric emptying of large single unit dosage forms

  1988cited by this paper
• Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects

  1987cited by this paper
• Circadian variation in gastric emptying of meals in humans.

  1987cited by this paper
• Dissolution rate and transit times of technetium-99m DTPA-labeled tablets.

  1987cited by this paper
• Effect of the menstrual cycle on gastric emptying.

  1987cited by this paper
• Gastric acidity dependent bioavailability of cinnarizine from two commercial capsules in healthy volunteers

  1986cited by this paper
• Gastrointestinal transit of a controlled release naproxen tablet formulation

  1986cited by this paper
• Transit of pharmaceutical dosage forms through the small intestine.

  1986influential reference
• Reduced ampicillin bioavailability following oral coadministration with chloroquine.

  1985cited by this paper
• The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulations

  1985cited by this paper
• Effect of diet on gastric secretion.

  1985cited by this paper
• Duodenal pH in health and duodenal ulcer disease: effect of a meal, Coca-Cola, smoking, and cimetidine.

  1984cited by this paper
• EFFECT OF STRESS ON THE GASTRIC EMPTYING OF CAPSULES

  1984cited by this paper
• The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)

  1984cited by this paper
• Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns.

  1983cited by this paper
• Gastrointestinal transit the effect of the menstrual cycle

  1981cited by this paper
• Gastrointestinal transit: the effect of the menstrual cycle.

  1981cited by this paper
• Effects of essential and nonessential amino acids on gastric emptying in the dog.

  1975cited by this paper
• Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device

  1974cited by this paper
• Duodenal pH values in normal controls and in patients with duodenal ulcer.

  1969cited by this paper
• Effect of different foods on the acidity of the gastric contents in patients with duodental ulcer. 3. Effect of altering the proportions of protein and carbohydrate.

  1968cited by this paper
• A relation between the chain length of fatty acids and the slowing of gastric emptying

  1968cited by this paper
• Some properties of an alimentary osmoreceptor mechanism

  1956cited by this paper

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  2025cites this paper
• Real-time monitoring and characterization of thin film drug delivery systems using optical coherence tomography.

  2025cites this paper
• Stabilization of Self-Pressurized Gelatin Capsules for Oral Delivery of Biologics

  2025influential citation
• Physiologically based absorption modeling to predict the bioequivalence of two apixaban formulations

  2024influential citation
• Mechanistic investigation of enzyme triggered release from a xyloglucan matrix tablet for controlled colonic drug delivery.

  2024cites this paper
• FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes

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• Inuit population have shorter gastric emptying, higher duodenal motility and altered pan-enteric micromilieu: a comparative study between Greenlandic and Danish populations with and without type 2 diabetes

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• Application of a Novel Dissolution Medium with Lipids for In Vitro Simulation of the Postprandial Gastric Content

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• Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ

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• Physiologically Based Biopharmaceutics Modeling of regional and colon absorption in humans.

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• The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

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• Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products.

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• Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human

  2023cites this paper
• Gastrointestinal Transit Times in Health as Determined Using Ingestible Capsule Systems: A Systematic Review

  2023influential citation
• Efficient colonic drug delivery in domestic pigs employing a tablet formulation with dual control concept.

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• Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus.

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• In Vitro Methodologies for Evaluating Colon-Targeted Pharmaceutical Products and Industry Perspectives for Their Applications

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• Tablet formulation with dual control concept for efficient colonic drug delivery.

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• Time-Based Formulation Strategies for Colon Drug Delivery

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• Drug Physicochemical Properties and Capsule Fill Determine Extent of Premature Gastric Release from Enteric Capsules

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  2022cites this paper
• Preparation and Characterization of Ticagrelor Solid Self nano-emulsion

  2022cites this paper
• The molecular determinants of glucagon-like peptide secretion by the intestinal L-cell.

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  2022cites this paper
• Columbus' egg: Oral drugs are absorbed in finite time.

  2022cites this paper
• In silico-in vitro estimation of lipophilicity and permeability association for succinimide derivatives using chromatographic anisotropic systems and parallel artificial membrane permeability assay (PAMPA).

  2022cites this paper
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• Microneedle patch based on molecular motor as a spatio-temporal controllable dosing strategy of L-DOPA for Parkinson’s disease

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  2021cites this paper
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  2021cites this paper
• Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review.

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• Prescribed Psychotropic Drugs in the Elderly

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• In vivo models to evaluate ingestible devices: present status and current trends.

  2021cites this paper
• In vitro models to evaluate ingestible devices: present status and current trends.

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability.

  2019cites this paper
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  2019cites this paper
• Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases.

  2019cites this paper
• All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance

  2018cites this paper
• Comparison of pH and motility of the small intestine of healthy subjects and patients with symptomatic constipation using the wireless motility capsule

  2018cites this paper
• Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.

  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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