COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments

Certain transmembrane ERAD substrates are segregated into specialized ER subdomains, termed ER-associated compartments (ERACs), before degradation. COPII components and Hsp40s act in the same pathway to sequester ERAD substrates into ERACs. The findings point to an as-yet-undefined role of COPII proteins in the formation of ERACs.

• Publication year

  2013

• Venue

  Molecular Biology of the Cell

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E12-08-0639PMID 23303252PMCID 3583666
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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