A novel cis-acting centromeric DNA element affects S. pombe centromeric chromatin structure at a distance

The chromatin structure of the central core region of Schizosaccharomyces pombe centromeric DNA is unusual. This distinctive chromatin structure is associated only with central core sequences in a functional context and is modulated by a novel cis-acting DNA element (centromere enhancer) within the functionally critical K centromeric repeat, which is found in multiple copies in all three S. pombe centromeres. The centromere enhancer alters central core chromatin structure from a distance and in an orientation-independent manner without altering the nucleosomal packaging of sequences between the enhancer and the central core. These findings suggest a functionally relevant structural interaction between the enhancer and the centromeric central core brought about by DNA looping.

• Publication year

  1995

• Venue

  Journal of Cell Biology

• Publication date

  1995-02-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.128.4.445PMID 7860624PMCID 2199894
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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