Altered Functioning of Both Renal Dopamine D1 and Angiotensin II Type 1 Receptors Causes Hypertension in Old Rats

No abstract is available for this paper.

• Publication year

  2012

• Venue

  HYPERTENSION

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/HYPERTENSIONAHA.112.192302PMID 22411927PMCID PMC3331925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats.

  2011influential reference
• Genetics of Salt-Sensitive Hypertension

  2011cited by this paper
• Tubular toxicity of proteinuria

  2011cited by this paper
• Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.

  2010cited by this paper
• Higher renal AT1 receptor affinity exaggerates Ang II induced Na/K‐ATPase stimulation in spontaneously hypertensive rats.

  2010cited by this paper
• Intrarenal Angiotensin III Infusion Induces Natriuresis and Angiotensin Type 2 Receptor Translocation in Wistar-Kyoto but not in Spontaneously Hypertensive Rats

  2009cited by this paper
• Dopamine and angiotensin as renal counterregulatory systems controlling sodium balance

  2009influential reference
• Thiol antioxidants regulate angiotensin II AT1 and arginine vasopressin V1 receptor functions differently in vascular smooth muscle cells.

  2009cited by this paper
• Ascorbic acid decreases the binding affinity of the AT1 receptor for angiotensin II.

  2008cited by this paper
• Renal ageing: Changes in the cellular mechanism of energy metabolism and oxidant handling (Review Article)

  2008cited by this paper
• Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides

  2008cited by this paper
• Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension.

  2008cited by this paper
• Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

  2008cited by this paper
• Loss of Biphasic Effect on Na/K-ATPase Activity by Angiotensin II Involves Defective Angiotensin Type 1 Receptor–Nitric Oxide Signaling

  2008cited by this paper
• The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

  2007cited by this paper
• Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

  2007cited by this paper
• Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

  2007cited by this paper
• Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats.

  2006influential reference
• Enhanced Angiotensin II-Induced Activation of Na+, K+-ATPase in the Proximal Tubules of Obese Zucker Rats

  2006cited by this paper
• The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4

  2006cited by this paper
• Mechanisms of Disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity

  2006cited by this paper
• Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

  2006cited by this paper
• Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.

  2006cited by this paper
• Dopamine receptor and hypertension.

  2005cited by this paper
• N-acetylcysteine decreases angiotensin II receptor binding in vascular smooth muscle cells.

  2005cited by this paper
• Arterial aging: is it an immutable cardiovascular risk factor?

  2005cited by this paper
• Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats.

  2005cited by this paper
• Reduced renal dopamine D1 receptor function in streptozotocin-induced diabetic rats.

  2004cited by this paper
• The Role of Phosphorylation in D1 Dopamine Receptor Desensitization

  2004cited by this paper
• Hypertension in the elderly

  2004cited by this paper
• Angiotensin AT1/AT2 Receptors: Regulation, Signalling and Function

  2003cited by this paper
• Increased Renal Angiotensin II AT1 Receptor Function in Obese Zucker Rat

  2003cited by this paper
• Renal Dopamine Receptors and Hypertension

  2003cited by this paper
• G protein-coupled receptor kinase 4 gene variants in human essential hypertension

  2002cited by this paper
• Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.

  2002cited by this paper
• Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4.

  2002cited by this paper
• Theodore Cooper Lecture: Renal dopamine system: paracrine regulator of sodium homeostasis and blood pressure.

  2001cited by this paper
• Renal Dopamine System: Paracrine Regulator of Sodium Homeostasis and Blood Pressure

  2001cited by this paper
• Diminished natriuretic response to dopamine in old rats is due to an impaired D1-like receptor-signaling pathway.

  2000cited by this paper
• Renal dopamine and sodium homeostasis

  2000cited by this paper
• Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects.

  1999cited by this paper
• Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension.

  1999cited by this paper
• Increased oxidative stress in renal proximal tubules of the spontaneously hypertensive rat: A mechanism for defective dopamine D1A receptor/G‐protein coupling

  1998cited by this paper
• Renal dopamine receptors in health and hypertension.

  1998cited by this paper
• Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases (*)

  1996cited by this paper
• Characterization of the G Protein-coupled Receptor Kinase GRK4

  1996cited by this paper
• Aging and the kidney.

  1996cited by this paper
• Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension.

  1996cited by this paper
• Renal responses to acute angiotensin II inhibition and administered angiotensin II in the aging, conscious, chronically catheterized rat.

  1993cited by this paper
• Oxidants, antioxidants, and the degenerative diseases of aging.

  1993cited by this paper
• Dopamine Fails to Inhibit Renal Tubular Sodium Pump in Hypertensive Rats

  1993cited by this paper
• An impairment of renal tubular DA-1 receptor function as the causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats.

  1992cited by this paper
• Hypertension in the elderly

  1990cited by this paper
• Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats.

  1990cited by this paper
• Muscarinic acetylcholine receptor-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes.

  1989cited by this paper
• Salt sensitivity and systemic hypertension in the elderly.

  1988cited by this paper
• Aging and the kidney.

  1986cited by this paper

• Age and associated hypertension impair hippocampal circuitry function and memory.

  2025cites this paper
• Investigation of the Effects of Losartan and Captopril on Rotenone-Induced Inflammation via TLR4/NLRP3 Pathway: An Integrative In Vitro and In Silico Study.

  2025cites this paper
• The role of the brain renin-angiotensin system in Parkinson´s disease

  2024cites this paper
• Fasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho

  2024cites this paper
• G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets

  2024cites this paper
• Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension.

  2023cites this paper
• The low dopamine hypothesis: A plausible mechanism underpinning residual urine, overactive bladder and nocturia (RON) syndrome in older patients.

  2023cites this paper
• Paeonol improves renal and vascular angiotensin II type 1 receptor function via inhibiting oxidative stress in spontaneously hypertensive rats

  2023cites this paper
• Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.

  2022cites this paper
• The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons

  2020cites this paper
• Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension

  2020cites this paper
• Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.

  2020cites this paper
• Vascular Aging and Central Aortic Blood Pressure: From Pathophysiology to Treatment

  2020cites this paper
• Tandem Requirement for Full Renal D1R and D5R Activity

  2019cites this paper
• A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function

  2019cites this paper
• Genetic Polymorphisms Associated with Reactive Oxygen Species and Blood Pressure Regulation

  2019cites this paper
• Exposure to graphene nanoparticles induces changes in measures of vascular/renal function in a load and form-dependent manner in mice

  2019cites this paper
• Long‐Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D1 Receptor–Mediated Sodium Excretion via Upregulation of G‐Protein–Coupled Receptor Kinase Type 4 Expression in Sprague‐Dawley Rats

  2018cites this paper
• Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly

  2018cites this paper
• In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring

  2018cites this paper
• Mechanisms of altered renal sodium handling in age-related hypertension.

  2018influential citation
• Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.

  2018cites this paper
• Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine D1 Receptor Dysfunction and Hypertension in Adult Rat Offspring

  2018cites this paper
• Dopamine reduces cell surface Na+/H+ exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling.

  2017cites this paper
• The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

  2017cites this paper
• Molecular Mechanism of Renal Tubule Transport Dopamine reduces cell surface Na (cid:2) /H (cid:2) exchanger-3 protein by decreasing NHE3 exocytosis and cell membrane recycling

  2017cites this paper
• Protein disulfide isomerase regulates renal AT1 receptor function and blood pressure in rats.

  2017cites this paper
• QGQS Granule in SHR Serum Metabonomics Study Based on Tools of UPLC-Q-TOF and Renin-Angiotensin-Aldosterone System Form Protein Profilin-1

  2017cites this paper
• G Protein–Coupled Receptor Kinases: Crucial Regulators of Blood Pressure

  2016cites this paper
• Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System

  2016cites this paper
• Structural equation modeling identifies markers of damage and function in the aging male Fischer 344 rat.

  2016cites this paper
• Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

  2016cites this paper
• Superoxide increases angiotensin II AT1 receptor function in human kidney‐2 cells

  2016cites this paper
• Human GRK4&ggr;142V Variant Promotes Angiotensin II Type I Receptor–Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition

  2016cites this paper
• G Protein-Coupled Receptor Kinase 4: Role in Hypertension

  2015cites this paper
• Age-related hypertension and salt sensitivity are associated with unique cortico-medullary distribution of D1R, AT1R, and NADPH-oxidase in FBN rats

  2015influential citation
• Gut microbiota in hypertension

  2015cites this paper
• Renal dopaminergic system: Pathophysiological implications and clinical perspectives.

  2015cites this paper
• Vascular biology of ageing—Implications in hypertension

  2015cites this paper
• Regulation of blood pressure, oxidative stress and AT1R by high salt diet in mutant human dopamine D5 receptor transgenic mice

  2015cites this paper
• Antihypertensive mechanisms of intra-renal dopamine

  2015cites this paper
• Altered signaling pathways linked to angiotensin II underpin the upregulation of renal Na(+)-ATPase in chronically undernourished rats.

  2014cites this paper
• Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats

  2014cites this paper
• Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring.

  2014cites this paper
• Aging-related dysregulation of dopamine and angiotensin receptor interaction.

  2014cites this paper
• Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress.

  2013cites this paper
• Transcription Factor Nrf2 Protects Renal Dopamine D1 Receptor Function During Oxidative Stress

  2013cites this paper
• A high-salt diet further impairs age-associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway rats.

  2013cites this paper
• Renal dopamine and angiotensin II receptor signaling in age-related hypertension.

  2013influential citation
• Human kidney-2 cells harbor functional dopamine D1 receptors that require Giα for Gq/11α signaling.

  2013cites this paper
• Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

  2013cites this paper
• Transcription Factor Nrf 2 Protects Renal Dopamine D 1 Receptor Function During Oxidative Stress

  year unknowncites this paper