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Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

G. N. Fredrikson,G. N. Fredrikson,D. V. Anand,D. Hopkins,R. Corder,R. Alm,E. Bengtsson,Prediman K. Shah,Prediman K. Shah,A. Lahiri,J. Nilsson

Published 2009 in Diabetologia

ABSTRACT

Aims/hypothesisOxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes.MethodsWe studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score.ResultsPatients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease.Conclusions/interpretationOur observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes.

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