The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Development

• Publication date

  1998-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9735366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

  1998influential reference
• RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes.

  1998cited by this paper
• Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers.

  1998cited by this paper
• The phenotype of mes-2, mes-3, mes-4 and mes-6, maternal-effect genes required for survival of the germline in Caenorhabditis elegans, is sensitive to chromosome dosage.

  1998cited by this paper
• The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.

  1998cited by this paper
• SET domain proteins modulate chromatin domains in eu- and heterochromatin

  1998cited by this paper
• The Drosophila esc and E(z) Proteins Are Direct Partners in Polycomb Group-Mediated Repression

  1998cited by this paper
• Yeast heterochromatin: regulation of its assembly and inheritance by histones.

  1998cited by this paper
• The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains

  1998cited by this paper
• Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila.

  1998cited by this paper
• Mammalian homologues of the Polycomb‐group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres

  1997influential reference
• SU(VAR)3‐7, a Drosophila heterochromatin‐associated protein and companion of HP1 in the genomic silencing of position‐effect variegation

  1997cited by this paper
• Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

  1997cited by this paper
• The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen.

  1997cited by this paper
• Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.

  1997cited by this paper
• PcG complexes and chromatin silencing.

  1997cited by this paper
• The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes

  1997cited by this paper
• Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.

  1997cited by this paper
• Co‐localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

  1997cited by this paper
• Positional cloning of a global regulator of anterior–posterior patterning in mice

  1996cited by this paper
• A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.

  1996cited by this paper
• Mutations in the Drosophila melanogaster gene encoding S-adenosylmethionine synthetase [corrected] suppress position-effect variegation.

  1996cited by this paper
• The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein.

  1996influential reference
• Mutations in the Drosophila melanogaster Gene Encoding S-adenosylmethionine Suppress Position-Effect Variegation

  1996cited by this paper
• Functional compartmentalization of the nucleus.

  1996cited by this paper
• The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution.

  1996influential reference
• Positional cloning of a global regulator of anterior-posterior patterning in mice.

  1996cited by this paper
• Locking in stable states of gene expression: transcriptional control during Drosophila development.

  1995cited by this paper
• Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster.

  1995influential reference
• The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function.

  1995influential reference
• Function of the Polycomb protein is conserved in mice and flies.

  1995cited by this paper
• Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila.

  1995cited by this paper
• The role of brahma and related proteins in transcription and development.

  1995cited by this paper
• Functional analysis of the chromo domain of HP1.

  1995cited by this paper
• Position effect variegation in Drosophila is associated with an altered chromatin structure.

  1995cited by this paper
• Genetic interactions and dosage effects of Polycomb group genes of Drosophila

  1995cited by this paper
• The PHD finger: implications for chromatin-mediated transcriptional regulation.

  1995influential reference
• A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster.

  1995cited by this paper
• Chromatin complexes regulating gene expression in Drosophila.

  1995cited by this paper
• Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

  1995cited by this paper
• Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression.

  1994cited by this paper
• Gene inactivation in Drosophiia mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre

  1994cited by this paper
• BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID.

  1994cited by this paper
• Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region.

  1994cited by this paper
• The protein encoded by the Drosophila position‐effect variegation suppressor gene Su(var)3‐9 combines domains of antagonistic regulators of homeotic gene complexes.

  1994cited by this paper
• Transcriptional activation modulated by homopolymeric glutamine and proline stretches.

  1994cited by this paper
• Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein.

  1994cited by this paper
• Expression of the polyhomeotic locus in development of Drosophila melanogaster

  1994cited by this paper
• Functional dissection of the yeast Cyc8–Tupl transcriptional co-repressor complex

  1994cited by this paper
• Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

  1994cited by this paper
• Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster.

  1994influential reference
• The Polycomb gene is differentially regulated during oogenesis and embryogenesis of Drosophila melanogaster.

  1993cited by this paper
• Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin.

  1993cited by this paper
• The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein.

  1993cited by this paper
• Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.

  1993cited by this paper
• Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster.

  1992cited by this paper
• Position effect variegation and chromatin proteins

  1992cited by this paper
• Molecular mechanisms of determination in Drosophila.

  1992cited by this paper
• Cell lineage‐specific expression of modulo, a dose‐dependent modifier of variegation in Drosophila.

  1992cited by this paper
• Protein phosphorylation is involved in the regulation of chromatin condensation during interphase

  1992cited by this paper
• Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products.

  1992cited by this paper
• The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.

  1992cited by this paper
• Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2

  1991cited by this paper
• A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants.

  1991cited by this paper
• Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene

  1991cited by this paper
• Interactions of thePolycomb group of genes with homeotic loci ofDrosophila

  1991cited by this paper
• The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

  1991cited by this paper
• Predicting coiled coils from protein sequences

  1991cited by this paper
• Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.

  1990cited by this paper
• Imprinting a determined state into the chromatin of Drosophila.

  1990cited by this paper
• Chromatin contract to silence

  1990cited by this paper
• Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

  1990cited by this paper
• Homeogene expression patterns and chromosomal imprinting.

  1990cited by this paper
• Gene expression. Chromatin contract to silence.

  1990cited by this paper
• Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

  1990cited by this paper
• Genetic interactions of the suppressor 2 of zeste region genes.

  1989cited by this paper
• Evidence that the leucine zipper is a coiled coil.

  1989cited by this paper
• Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila.

  1989cited by this paper
• Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

  1988influential reference
• Dosage-Dependent Modifiers of Homoeotic Mutations in Drosophila melanogaster.

  1987cited by this paper
• Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.

  1985cited by this paper
• A group of genes controlling the spatial expression of the bithorax complex in Drosophila

  1985cited by this paper
• Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.

  1984cited by this paper
• Homoeosis in Drosophila: a new enhancer of polycomb and related homoeotic mutations.

  1983cited by this paper
• Homoeosis in drosophila: maternal effect of the enhancer of polycomb locus and its interaction with polycomb and related loci

  1983cited by this paper
• Position-effect variegation.

  1968cited by this paper
• Interactions of the Polycomb group of genes with homeotic loci of Drosophila

  year unknowncited by this paper
• Identification and Characterization of Interactions between the Vertebrate Polycomb-Group Protein BMI1 and Human Homologs of Polyhomeotic

  year unknowncited by this paper

• Functional analysis of human EED variants using Drosophila

  2025cites this paper
• BRPF1 in cancer epigenetics: a key regulator of histone acetylation and a promising therapeutic target

  2025cites this paper
• Interpreting mammalian synonymous site conservation in light of the unwanted transcript hypothesis

  2025cites this paper
• Genetic analysis of scab disease resistance in common bean (Phaseolus vulgaris) varieties using GWAS and functional genomics approaches

  2024cites this paper
• The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis.

  2022cites this paper
• LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies

  2021cites this paper
• Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1

  2021cites this paper
• The role of HOPX in normal tissues and tumor progression

  2020cites this paper
• Differential gene expression profiling of one- and two-dimensional apogamous gametophytes of the fern Dryopteris affinis ssp. affinis.

  2020cites this paper
• Beneficial mutations for carotenoid production identified from laboratory-evolved Saccharomyces cerevisiae

  2019cites this paper
• Critical genomic regulation mediated by Enhancer of Polycomb

  2018cites this paper
• The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing

  2018cites this paper
• Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis

  2018cites this paper
• Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1

  2017cites this paper
• Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis

  2017cites this paper
• THE CHROMATIN FACTOR ENHANCER OF POLYCOMB PROMOTES DIFFERENTIATION OF ADULT GERMLINE STEM CELLS AND CYST STEM CELLS IN THE DROSOPHILA TESTIS

  2016influential citation
• HOPX: The Unusual Homeodomain-Containing Protein.

  2016cites this paper
• Transcriptome Analysis of Thermal Parthenogenesis of the Domesticated Silkworm

  2015cites this paper
• RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.

  2015cites this paper
• Site specificity analysis of Piccolo NuA4-mediated acetylation for different histone complexes.

  2015cites this paper
• Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival

  2015cites this paper
• Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures

  2015cites this paper
• The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development.

  2015cites this paper
• Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells

  2014cites this paper
• Acquisition of a Leucine Zipper Motif as a Mechanism of Antimorphy for an Allele of the Drosophila Hox Gene Sex Combs Reduced

  2014cites this paper
• PFP1, a Gene Encoding an Epc-N Domain-Containing Protein, Is Essential for Pathogenicity of the Barley Pathogen Rhynchosporium commune

  2014cites this paper
• 1 PFP 1 , a gene encoding an Epc-N domain-containing protein , is essential for 1 pathogenicity of the barley pathogen Rhynchosporium commune 2 3 4

  2014cites this paper
• Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

  2013cites this paper
• Investigating the functional significance of evolutionarily conserved protein motifs of the Drosophila melanogaster HOX protein, Sex combs reduced

  2013influential citation
• Bortezomib Reduces the Tumorigenicity of Multiple Myeloma via Downregulation of Upregulated Targets in Clonogenic Side Population Cells

  2013cites this paper
• Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

  2013cites this paper
• FUNCTIONAL ANALYSIS OF POLYCOMB GROUP PROTEINS IN THE SILKWORM, BOMBYX MORI

  2012cites this paper
• Identification and characterization of Polycomb group genes in the silkworm, Bombyx mori

  2012cites this paper
• Human Tip60 (NuA4) Complex and Cancer

  2012cites this paper
• In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila

  2012cites this paper
• The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting

  2011cites this paper
• Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation

  2011influential citation
• Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes

  2011cites this paper
• Repressing the repressor: A new mode of MYC action in lymphomagenesis

  2009cites this paper
• Maintenance of the patterns of expression of homeotic genes in the development of Drosophila melanogaster by proteins of the polycomb, trithorax, and ETP groups

  2009cites this paper
• Enhancer-promoter communication at the Drosophila engrailed locus

  2009cites this paper
• Enhancer of Polycomb1 Acts on Serum Response Factor to Regulate Skeletal Muscle Differentiation*

  2009cites this paper
• Epigenetikus szabályozó faktorok azonosítása és jellemzése Drosophila melanogaster-ben

  2009cites this paper
• Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T‐cell leukemia/lymphoma

  2009cites this paper
• TaqMan low density array is roughly right for gene expression quantification in colorectal cancer.

  2008cites this paper
• TOWARDS UNDERSTANDING THE MECHANISMS OF EPIGENETIC REGULATION: PART 1. AN EVOLUTIONAL INSIGHT INTO PCG-MEDIATED GENE REPRESSION

  2008cites this paper
• Tissue-Specific Defects Are Caused by Loss of the Drosophila MAN1 LEM Domain Protein

  2008cites this paper
• RSF Governs Silent Chromatin Formation via Histone H2Av Replacement

  2008cites this paper
• For genes that encode one component of a multimeric protein complex, measuring only one phenotype often gives a biased view of function: SU(VAR)3-9 and chromatin architecture as an example

  2008cites this paper
• Enhancer of Polycomb1, a Novel Homeodomain Only Protein-binding Partner, Induces Skeletal Muscle Differentiation*

  2007cites this paper
• From genetics to epigenetics: the tale of Polycomb group and trithorax group genes

  2006cites this paper
• Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.

  2006cites this paper
• Drosophila Reptin and Other TIP60 Complex Components Promote Generation of Silent Chromatin

  2006cites this paper
• The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins

  2006influential citation
• Molecular analysis of Hydra embryonic development by means of subtractive hybridization

  2006cites this paper
• Maintenance of gene expression patterns

  2005cites this paper
• The Saccharomyces cerevisiae Piccolo NuA4 Histone Acetyltransferase Complex Requires the Enhancer of Polycomb A Domain and Chromodomain To Acetylate Nucleosomes

  2005cites this paper
• A Novel Repressive E2F6 Complex Containing the Polycomb Group Protein, EPC1, That Interacts with EZH2 in a Proliferation-specific Manner*

  2005cites this paper
• Domaines protéiques du complexe histone acétyltransférase NuA4 impliqués dans la transcription et le maintien de l'intégrité du génome

  2005cites this paper
• Interactions du complexe multiprotéique NuA4 dans la dynamique chromatinienne

  2005cites this paper
• Interaction of MLL amino terminal sequences with menin is required for transformation.

  2005cites this paper
• Genomic Approaches That Aid in the Identification of Transcription Factor Target Genes

  2004cites this paper
• Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster

  2004cites this paper
• The MYST family of histone acetyltransferases.

  2003cites this paper
• The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc

  2003cites this paper
• Identification and characterization of polyhomeotic PREs and TREs.

  2003cites this paper
• Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis.

  2003cites this paper
• Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin.

  2003cites this paper
• Intercalary Heterochromatin in Drosophila Melanogaster Polytene Chromosomes and the Problem of Genetic Silencing

  2003cites this paper
• Role for O-glycosylation of RFP in the interaction with enhancer of polycomb.

  2002cites this paper
• Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes

  2002influential citation
• Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogaster.

  2002cites this paper
• Sequence Relationships, Conserved Domains, and Expression Patterns for Maize Homologs of the Polycomb Group GenesE(z), esc, andE(Pc) 1

  2002cites this paper
• Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogaster.

  2002cites this paper
• Multiple effects of genetic background on variegated transgene expression in mice.

  2002influential citation
• Evolutionary conservation of the chromatin modulator Polycomb in the jellyfish Podocoryne carnea.

  2002cites this paper
• Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans.

  2001cites this paper
• The Yeast NuA4 and Drosophila MSL Complexes Contain Homologous Subunits Important for Transcription Regulation*

  2001cites this paper
• CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.

  2001cites this paper
• Variegated transgene expression in mice

  2001cites this paper
• Mechanisms of transcriptional memory

  2001cites this paper
• The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3.

  2001cites this paper
• Translating the Histone Code

  2001cites this paper
• The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes.

  2001cites this paper
• Silencing, Heterochromatin and DNA Double Strand Break Repair

  2000cites this paper
• Polycomb-group genes and hematopoiesis.

  2000cites this paper
• RET Finger Protein Is a Transcriptional Repressor and Interacts with Enhancer of Polycomb That Has Dual Transcriptional Functions*

  2000cites this paper
• Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.

  2000influential citation
• Polycomb group protein complexes: do different complexes regulate distinct target genes?

  1999cites this paper
• Misexpression of Polycomb-group proteins in Xenopus alters anterior neural development and represses neural target genes.

  1999cites this paper
• RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1

  1999cites this paper
• Boundaries that demarcate structural and functional domains of chromatin

  1999cites this paper
• Cloning mammalian homologs of Drosophila genes

  1999cites this paper
• A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.

  1999cites this paper
• Experimental Biology and Medicine Minireview Genomic Approaches That Aid in the Identification of Transcription Factor Target Genes

  year unknowncites this paper
• CHMP 1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression

  year unknowncites this paper