Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPHEART.00257.2001PMID 11788422
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Free fatty acid metabolism during myocardial ischemia and reperfusion

  2004cited by this paper
• [Mitochondrial carnitine palmitoyltransferase].

  2002cited by this paper
• Lysophosphatidylethanolamine acyltransferase activity is elevated during cardiac cell differentiation.

  2000cited by this paper
• Nitroprusside induces cardiomyocyte death: interaction with hydrogen peroxide.

  2000cited by this paper
• Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A.

  2000cited by this paper
• Modulation of palmitate-induced cardiomyocyte cell death by interventions that alter intracellular calcium.

  1999cited by this paper
• Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

  1998cited by this paper
• Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

  1998cited by this paper
• Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.

  1998cited by this paper
• Maturation of fatty acid and carbohydrate metabolism in the newborn heart

  1998cited by this paper
• Mechanisms of control of heart glycolysis.

  1998cited by this paper
• The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

  1997cited by this paper
• Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes.

  1997influential reference
• Effects of fasting, hypoxia, methylpalmoxirate and oxfenicine on the tissue-levels of long-chain acyl CoA and acylcarnitine in the rat atria.

  1997cited by this paper
• Carnitine palmitoyl-transferase enzyme inhibition protects proximal tubules during hypoxia.

  1997cited by this paper
• The flux control coefficient of carnitine palmitoyltransferase I on palmitate beta-oxidation in rat hepatocyte cultures.

  1997cited by this paper
• Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis*

  1997influential reference
• Fumonisin toxicity and sphingolipid biosynthesis.

  1996influential reference
• Substrate metabolism in the developing heart.

  1996cited by this paper
• Regulation of fatty acid oxidation by acetyl-CoA generated from glucose utilization in isolated myocytes.

  1996cited by this paper
• Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway

  1996cited by this paper
• Ceramide: A stress signal and mediator of growth suppression and apoptosis

  1995cited by this paper
• Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart (*)

  1995cited by this paper
• Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts.

  1995cited by this paper
• Regulation of fatty acid oxidation in the mammalian heart in health and disease.

  1994influential reference
• Estimation of peroxisomal beta-oxidation in rat heart by a direct assay of acyl-CoA oxidase.

  1994cited by this paper
• Cellular uncoupling induced by accumulation of long-chain acylcarnitine during ischemia.

  1994cited by this paper
• The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart.

  1994influential reference
• Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.

  1993cited by this paper
• Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.

  1992cited by this paper
• Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart.

  1992cited by this paper
• Fatty acid homeostasis in the normoxic and ischemic heart.

  1992cited by this paper
• NADH-dependent dehydrogenase activity estimation by flow cytometric analysis of 3-(4,5-dimethylthiazolyl-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.

  1992cited by this paper
• Glucose and palmitate oxidation in isolated working rat hearts reperfused after a period of transient global ischemia.

  1990cited by this paper
• Acute hormonal control of acetyl-CoA carboxylase. The roles of insulin, glucagon, and epinephrine.

  1990influential reference
• Identification of an isozymic form of acetyl-CoA carboxylase.

  1990cited by this paper
• An update of the enzymology and regulation of sphingomyelin metabolism.

  1990cited by this paper
• Effects of the fatty acid blocking agents, oxfenicine and 4-bromocrotonic acid, on performance in aerobic and ischemic myocardium.

  1987cited by this paper
• Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria.

  1986cited by this paper
• Limitation of myocardial infarct size by metabolic interventions that reduce accumulation of fatty acid metabolites in ischemic myocardium.

  1986cited by this paper
• Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine.

  1985cited by this paper
• Structural analysis and subunit interaction of insulin receptor from membranes of cultured embryonic chick heart cells.

  1984cited by this paper
• Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.

  1984influential reference
• Changes in myocardial substrate utilisation and protection of ischemic stressed myocardium by oxfenicine [(S)-4-hydroxyphenylglycine]

  1984cited by this paper
• Carnitine--metabolism and functions.

  1983cited by this paper
• Regulation of glycolytic flux in the heart of the fetal guinea pig.

  1983cited by this paper
• Regulation of glycolytic flux in the heart of the fetal guinea pig.

  1983cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983influential reference
• Characterization of carnitine transport in isolated perfused adult rat hearts.

  1982cited by this paper
• Influence of free fatty acids on myocardial oxygen consumption and ischemic injury.

  1981cited by this paper
• Protection of the ischaemic dog heart by oxfenicine.

  1981cited by this paper
• Oxfenicine diverts rat muscle metabolism from fatty acid to carbohydrate oxidation and protects the ischaemic rat heart.

  1980cited by this paper
• Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep.

  1980cited by this paper
• Effect of insulin in vivo on the synthesis of free fatty acids (FFA) in chicken heart and skeletal muscle

  1980cited by this paper
• Developmental control of 2-aminoisobutyric acid transport by 7-and 14-day chick heart cell aggregates. Roles of insulin and amino acids.

  1978cited by this paper
• Effects of Excess Free Fatty Acids on Mechanical and Metabolic Function in Normal and Ischemic Myocardium in Swine

  1978cited by this paper
• Letter: Exercise, sport, and sudden death.

  1975cited by this paper
• INTERACTION OF FATTY ACID AND GLUCOSE OXIDATION BY CULTURED HEART CELLS

  1973influential reference
• Some ultrastructural and biochemical aspects of heart mitochondria associated with development: fetal and cardiomyopathic tissue.

  1972cited by this paper
• Cellular energy metabolism during fetal development. IV. Fatty acid activation, acyl transfer and fatty acid oxidation during development of the chick and rat.

  1972cited by this paper
• Genetic susceptibility and somatic mutation in the production of freckles, birthmarks and moles.

  1968cited by this paper
• Relation between serum-free-fatty acids and arrhythmias and death after acute myocardial infarction.

  1968cited by this paper

• Unraveling the choline pathway in heart failure risk and outcomes: A systematic review and meta-analysis.

  2025cites this paper
• De novo lipid synthesis in cardiovascular tissue and disease.

  2024cites this paper
• Functions and origins of cardiac fat

  2022cites this paper
• Evaluating the adverse outcome of subtypes of heart failure with preserved ejection fraction defined by machine learning: A systematic review focused on defining high risk phenogroups

  2022cites this paper
• Upstream regulators of apoptosis mediates methionine-induced changes of lipid metabolism.

  2018cites this paper
• The role of stearoyl-CoA desaturase in the regulation of cardiac metabolism

  2018influential citation
• Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

  2018cites this paper
• Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid

  2017cites this paper
• Fatty acid vesicles acting as expanding horizon for transdermal delivery

  2017cites this paper
• THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE

  2017cites this paper
• Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins

  2016cites this paper
• dysfunctionand does not exacerbate left ventricular High-fat diet postinfarction enhances mitochondrial

  2016cites this paper
• Metabolic reprogramming of the heart through stearoyl-CoA desaturase.

  2015influential citation
• Uncovering a Novel Role of the Apoptotic Initiator Caspase, Caspase-2

  2014cites this paper
• Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients

  2014cites this paper
• Palmitic Acid and Ergosta-7,22-dien-3-ol Contribute to the Apoptotic Effect and Cell Cycle Arrest of an Extract from Marthasterias glacialis L. in Neuroblastoma Cells

  2013cites this paper
• Monounsaturated 14:1n-9 and 16:1n-9 Fatty Acids but not 18:1n-9 Induce Apoptosis and Necrosis in Murine HL-1 Cardiomyocytes

  2013cites this paper
• Prostaglandins, Leukotrienes and Essential Fatty Acids

  2013cites this paper
• Stearoyl-CoA Desaturase in the Control of Heart Metabolism

  2013cites this paper
• Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax.

  2012cites this paper
• Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways.

  2011cites this paper
• pathwaysis mediated by mitochondrial-dependent Increased propensity for cell death in diabetic human

  2011cites this paper
• Impact de facteurs sanguins et d'agents thérapeutiques sur la survie de fibroblastes de sujets atteints de la forme canadienne-française du syndrome de Leigh (LSFC)

  2011cites this paper
• The effect of CPT-1 inhibition on myocardial function and resistance to ischemia/reperfusion injury in a rodent model of the metabolic syndrome

  2010cites this paper
• Влияние пальмитиновой кислоты на содержание кардиолипина и фосфатидной кислоты в изолированных гепатоцитах крыс

  2010cites this paper
• Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide[S]

  2010cites this paper
• Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis*

  2010cites this paper
• Stearic acid‐induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone

  2009influential citation
• Induction of apoptosis by l-carnitine through regulation of two main pathways in Hepa1c1c 7 cells

  2009cites this paper
• Verapamil but not calpain or creatine alters arsenate-induced cardiac cell death

  2009cites this paper
• The adipose triglyceride lipase, adiponectin and visfatin are downregulated by tumor necrosis factor-alpha (TNF-alpha) in vivo.

  2009cites this paper
• Apoptosis in Human Acute Myocardial Infarction: The Rationale for Clinical Trials of Apoptosis Inhibition in Acute Myocardial Infarction

  2009cites this paper
• Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.

  2009cites this paper
• Desaturase activities and metabolic control in type 2 diabetes.

  2008cites this paper
• Palmitate-induced NO production has a dual action to reduce cell death through NO and accentuate cell death through peroxynitrite formation.

  2008influential citation
• Increased Myocardial Susceptibility to Repetitive Ischemia With High‐fat diet‐induced Obesit

  2008cites this paper
• Role of diet and fuel overabundance in the development and progression of heart failure.

  2008cites this paper
• Effects of high saturated fat on myocardial contractile and mitochondrial function in heart failure

  2008cites this paper
• Contribution Of Sphingolipids To The Pathogenesis Of Obesity

  2007cites this paper
• High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction.

  2007cites this paper
• Epicardial fat: properties, function and relationship to obesity

  2007cites this paper
• Cardiac cell death in early diabetes : modulation by glutathione and polyunsaturated fatty acids

  2006influential citation
• Ceramides in insulin resistance and lipotoxicity.

  2006cites this paper
• Cardiac cell death in early diabetes and its modulation by dietary fatty acids.

  2006cites this paper
• Metabolic remodeling in the aging heart.

  2006cites this paper
• Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis.

  2005cites this paper
• Fatty acid metabolism is enhanced in type 2 diabetic hearts.

  2005cites this paper
• Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids.

  2005cites this paper
• CPT 1 a over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293 T cells q

  2005cites this paper
• Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

  2005cites this paper
• Fatty acid metabolism and control of food intake

  2005cites this paper
• Mitochondrial energy metabolism in heart failure: a question of balance.

  2005cites this paper
• Lipotoxicity in the heart

  2005cites this paper
• CPT1alpha over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293T cells.

  2005cites this paper
• The association between RhoB and caspase-2: changes with lovastatin-induced apoptosis.

  2005cites this paper
• Regular exercise is associated with a protective metabolic phenotype in the rat heart.

  2004cites this paper
• Palmitate increases nitric oxide synthase activity that is involved in palmitate-induced cell death in cardiomyocytes.

  2004cites this paper
• Fatty acid oxidation and control of food intake.

  2004cites this paper
• Reduction of palmitate-induced cardiac apoptosis by fenofibrate

  2004cites this paper
• Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA.

  2004cites this paper
• Modified fatty acids and their possible therapeutic targets in malignant diseases

  2003cites this paper
• Mechanisms of Palmitate-induced Cardiomyocyte Apoptosis

  2003cites this paper
• Lipotoxicity: when tissues overeat

  2003cites this paper
• Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate.

  2003cites this paper
• The Antianginal Agent Trimetazidine Does Not Exert Its Functional Benefit via Inhibition of Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

  2003cites this paper
• Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid.

  2003cites this paper
• Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts

  2003cites this paper
• Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes.

  2002cites this paper
• Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation.

  2002cites this paper
• The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure

  2002cites this paper