The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Endocrinology

• Publication date

  2004-04-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1677/JOE.0.1810039PMID 15072565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypothalamic control of gonadotrophin and prolactin secretion in pigs.

  2020cited by this paper
• Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

  2002cited by this paper
• Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats

  2001cited by this paper
• Overview of central targets for appetite regulation

  2001cited by this paper
• Common Requirements for Melanocortin-4 Receptor Selectivity of Structurally Unrelated Melanocortin Agonist and Endogenous Antagonist, Agouti Protein*

  2001cited by this paper
• A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits

  2000cited by this paper
• Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes.

  2000cited by this paper
• Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding.

  2000cited by this paper
• Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

  2000cited by this paper
• Hypothalamic control of feeding.

  1999cited by this paper
• The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats.

  1999cited by this paper
• Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.

  1999cited by this paper
• Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.

  1999cited by this paper
• Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.

  1999cited by this paper
• The Central Melanocortin System and Energy Homeostasis.

  1999cited by this paper
• Type I beta-turn conformation is important for biological activity of the melanocyte-stimulating hormone analogues.

  1999cited by this paper
• Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist

  1999cited by this paper
• Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion.

  1998cited by this paper
• Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands.

  1998cited by this paper
• A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo.

  1998cited by this paper
• Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats.

  1998cited by this paper
• Melanocortin mediated inhibition of feeding behavior in rats.

  1998cited by this paper
• Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine.

  1998cited by this paper
• Melanocortin receptors in leptin effects

  1997cited by this paper
• Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

  1997cited by this paper
• Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

  1997cited by this paper
• Targeted disruption of the melanocortin-4 receptor results in obesity in mice.

  1997cited by this paper
• Overexpression of Agrt leads to obesity in transgenic mice

  1997cited by this paper
• Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.

  1997cited by this paper
• Leptin: the voice of the adipose tissue.

  1997cited by this paper
• Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides.

  1996cited by this paper
• Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

  1995cited by this paper
• Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans

  1995cited by this paper
• Intracerebroventricular injection of corticotropin-releasing hormone in the pig: acute effects on behavior, adrenocorticotropin secretion, and immune suppression.

  1994cited by this paper
• Growth hormone-releasing hormone and somatostatin neurons within the porcine and bovine hypothalamus.

  1994cited by this paper
• Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

  1993cited by this paper
• Isolation of DNA from blood.

  1991cited by this paper
• Endocrine changes in sows exposed to elevated ambient temperature during lactation.

  1991cited by this paper
• Gonadotropin and Prolactin Secretion following Intraventricular Administration of Morphine in Gilts

  1990cited by this paper
• Absence of an estradiol-induced surge of luteinizing hormone in pigs receiving unvarying pulsatile gonadotropin-releasing hormone stimulation.

  1987cited by this paper
• Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome.

  1986cited by this paper
• Inhibition of ovulation and LH secretion in the gilt after treatment with ACTH or hydrocortisone.

  1982cited by this paper
• Nutrient requirements of swine

  1964cited by this paper

• ASSOCIATION BETWEEN SNP MARKERS AND MILK PRODUCTION TRAIT OF SWAMP BUFFALO

  2025cites this paper
• Relationships of genomic estimated breeding values for age at puberty, birth weight, and growth during development in normal cyclic and acyclic gilts.

  2023cites this paper
• Possible effects of the MC4R Asp298Asn polymorphism on pig production traits under ad libitum versus restricted feeding.

  2022cites this paper
• Mutations in melanocortin-4 receptor: From fish to men.

  2022cites this paper
• The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

  2021cites this paper
• Influence of MC4R mutations in traits of tested Danube white purebred pigs

  2021influential citation
• Genomic Analysis Using Bayesian Methods under Different Genotyping Platforms in Korean Duroc Pigs

  2020cites this paper
• Physiological and genomic insight into neuroendocrine regulation of puberty in gilts.

  2020cites this paper
• Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK signaling pathway after weight loss in obese Sprague-Dawley rats.

  2019cites this paper
• Review: kisspeptin and reproduction in the pig.

  2019cites this paper
• Role of the gut, melanocortin system and malonyl-CoA in control of feed intake in non-ruminant animals

  2018cites this paper
• Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

  2018cites this paper
• Effect of the missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic

  2018influential citation
• Pharmacological characterization and functional rescue of the giant panda and human melanocortin-4 receptors

  2017cites this paper
• Design of cyclized selective melanotropins

  2016cites this paper
• Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes.

  2016cites this paper
• Residual feed intake studies in Angus-sired cattle reveal a potential role for hypothalamic gene expression in regulating feed efficiency.

  2014cites this paper
• Association between melanocortin 4 receptor (MC4R) gene haplotypes and carcass and production traits in Italian Large White pigs evaluated with a selective genotyping approach

  2013cites this paper
• Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line

  2013cites this paper
• Obesity Pharmacotherapy: Current Perspectives and Future Directions

  2013cites this paper
• G protein-coupled receptors as regulators of energy homeostasis.

  2013cites this paper
• Elucidation of the roles of agouti related proteins in zebrafish

  2012cites this paper
• Effects of weaning and syndyphalin-33 on expression of melanocortinergic appetite-regulating genes in swine.

  2011cites this paper
• Triennial Growth Symposium: neural regulation of feed intake: modification by hormones, fasting, and disease.

  2011cites this paper
• Association of the Asp298Asn polymorphism in the mc4r gene with back fat thickness in pigs of the large white breed

  2011cites this paper
• The melanocortin system is involved in regulating autonomic nerve activity through central pituitary adenylate cyclase-activating polypeptide.

  2011influential citation
• Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.

  2011cites this paper
• The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

  2010cites this paper
• Effect of mutation in MC4R gene on carcass quality in Pulawska pig included in conservation breeding programme.

  2010cites this paper
• Effects of selection for low residual feed intake and feed restriction on gene expression profiles and thyroid axis in pigs

  2010cites this paper
• PART I. DESIGN AND SYNTHESIS OF BICYCLIC INTERNAL BETA-TURN MIMETICS AND THEIR INCORPORATION INTO BIOLOGICALLY ACTIVE LIGANDS; PART II. SYNTHESIS OF CYCLIC PEPTIDES BY RING

  2010cites this paper
• Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations.

  2010cites this paper
• PHARMACOLOGICAL CHARACTERIZATION OF CANINE MELANOCORTIN-4 RECEPTOR AND ITS NATURAL VARIANT V213F

  2009cites this paper
• Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant.

  2009cites this paper
• Microarray gene expression profiles of fasting induced changes in liver

  2009cites this paper
• Detailed characterization of the porcine MC4R gene in relation to fatness and growth.

  2009cites this paper
• Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs.

  2008cites this paper
• Engineering the Melanocortin-4 Receptor to Control Constitutive and Ligand-Mediated Gs Signaling In Vivo

  2007cites this paper
• Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor.

  2007cites this paper
• Anticatabolic properties of melanocortin-4 receptor antagonists

  2006cites this paper
• Leptin in Farm Animals

  2006cites this paper
• Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs.

  2006cites this paper
• Melanocortin-4 receptor in sheep: a potential site for therapeutic intervention in disease models.

  2005cites this paper
• Regulation der Nahrungsaufnahme: Physiologische Mechanismen und klinische Relevanz

  2005cites this paper
• Physiology of ghrelin and related peptides.

  2005cites this paper
• A Role for Agouti-Related Protein in Appetite Regulation in a Species with Continuous Nutrient Delivery

  2005cites this paper
• MC1R and the response of melanocytes to ultraviolet radiation.

  2005cites this paper
• Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.

  2005cites this paper
• Neuroendocrinology of nutritional infertility.

  2004cites this paper