A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD

AKAP79/150 is a protein scaffold that is thought to position specific kinases (protein kinase A and C) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor–dependent long-term depression solely because of its interaction with calcineurin.

• Publication year

  2010

• Venue

  Nature Neuroscience

• Publication date

  2010-08-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nn.2613PMID 20694001PMCID 2943866
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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