The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochemical Journal

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ20101210PMID 21143199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Music Received

  2023cited by this paper
• Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding*

  2010cited by this paper
• Proapoptotic function of the retinoblastoma tumor suppressor protein.

  2009cited by this paper
• Emerging roles of E2Fs in cancer: an exit from cell cycle control

  2009cited by this paper
• Cellular mechanisms of tumour suppression by the retinoblastoma gene

  2008cited by this paper
• Mouse development with a single E2F activator

  2008cited by this paper
• An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.

  2008cited by this paper
• Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation

  2008cited by this paper
• Tailoring to RB: tumour suppressor status and therapeutic response

  2008cited by this paper
• Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3

  2008cited by this paper
• Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.

  2007cited by this paper
• Amplify this! DNA and RNA get a third base pair

  2006cited by this paper
• Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb

  2006cited by this paper
• Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

  2005cited by this paper
• The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells1

  2004cited by this paper
• p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

  2004cited by this paper
• Multiple sequence alignment with the Clustal series of programs

  2003cited by this paper
• Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase

  2003cited by this paper
• Differential regulation of E2F1 apoptotic target genes in response to DNA damage

  2003cited by this paper
• Specificity in the activation and control of transcription factor E2F-dependent apoptosis

  2003cited by this paper
• Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

  2003cited by this paper
• pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.

  2003cited by this paper
• G1 Cyclin/Cyclin-dependent Kinase-coordinated Phosphorylation of Endogenous Pocket Proteins Differentially Regulates Their Interactions with E2F4 and E2F1 and Gene Expression*

  2002cited by this paper
• Gene expression changes in response to E2F1 activation.

  2002cited by this paper
• Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins

  2002cited by this paper
• The RB and p53 pathways in cancer.

  2002cited by this paper
• Direct coupling of the cell cycle and cell death machinery by E2F

  2002cited by this paper
• Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.

  2002cited by this paper
• Acetylation control of the retinoblastoma tumour-suppressor protein

  2001cited by this paper
• Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins

  2000cited by this paper
• Role for the p53 homologue p73 in E2F-1-induced apoptosis

  2000cited by this paper
• A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.

  1999cited by this paper
• Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

  1999cited by this paper
• Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis.

  1999cited by this paper
• Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.

  1999cited by this paper
• Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

  1998cited by this paper
• Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

  1998cited by this paper
• Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

  1998cited by this paper
• The regulation of E2F by pRB-family proteins.

  1998cited by this paper
• Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

  1997cited by this paper
• pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

  1997cited by this paper
• E2F-1 functions in mice to promote apoptosis and suppress proliferation.

  1996cited by this paper
• E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

  1996cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Distinct sub‐populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

  1994cited by this paper
• Distinct roles for cyclin-dependent kinases in cell cycle control.

  1993cited by this paper
• Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.

  1992cited by this paper
• The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

  1992cited by this paper
• Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

  1991cited by this paper
• T98G: An anchorage‐independent human tumor cell line that exhibits stationary phase G1 arrest in vitro

  1979cited by this paper

• Cell proliferation suppressor RBR1 interacts with ARID1 to promote pollen mitosis via stabilizing DUO1 in Arabidopsis.

  2025cites this paper
• Rb-E2F-HDAC Repressor Complexes Control Interferon-Induced Repression of Adenovirus To Promote Persistent Infection

  2022cites this paper
• Scholarship@Western Scholarship@Western

  2022cites this paper
• Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility

  2022cites this paper
• Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?

  2021cites this paper
• RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report

  2020cites this paper
• RB1 deletion in RB-pathway disrupted cells results in DNA damage and cancer progression

  2019cites this paper
• RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

  2019cites this paper
• Immunohistochemical Detection of the Retinoblastoma Protein.

  2018cites this paper
• Context dependent roles for RB-E2F transcriptional regulation in tumor suppression

  2018cites this paper
• Using zebrafish to elucidate the epigenetic mechanisms controlling neurogenesis and brain tumorigenesis

  2018cites this paper
• Non-canonical functions of the RB protein in cancer

  2018cites this paper
• An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation

  2018cites this paper
• Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

  2017cites this paper
• Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment

  2017cites this paper
• Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas.

  2017cites this paper
• Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control

  2017cites this paper
• Investigating E2F independent cell cycle control and tumor suppression by pRB

  2017cites this paper
• The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts

  2017cites this paper
• E2F1: Transcriptional Machinery in Colon Cancer

  2017cites this paper
• An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.

  2016cites this paper
• An RB-EZH 2 Complex Med iates Silencing of Repetitive DNA Sequences Graphical Abstract Highlights

  2016cites this paper
• Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.

  2016cites this paper
• Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system.

  2015cites this paper
• The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency*

  2015cites this paper
• Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis

  2015influential citation
• Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures

  2015cites this paper
• Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation

  2015cites this paper
• Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

  2015cites this paper
• Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy.

  2015cites this paper
• Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.

  2014cites this paper
• A Retinoblastoma Allele That Is Mutated at Its Common E2F Interaction Site Inhibits Cell Proliferation in Gene-Targeted Mice

  2014influential citation
• Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.

  2014cites this paper
• Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation

  2014cites this paper
• Analyzing RB and E2F during the G1-S transition.

  2014cites this paper
• Cell Cycle Control

  2014cites this paper
• The retinoblastoma protein and PML collaborate to organize heterochromatin and silence E2F-responsive genes during senescence

  2014cites this paper
• Characterizing the role of the Retinoblastoma protein LXCXE binding cleft in cellular senescence and tumor suppression

  2013cites this paper
• Genome-Wide Analysis of Alternative Splicing during Dendritic Cell Response to a Bacterial Challenge

  2013cites this paper
• pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737

  2013cites this paper
• Molecular mechanisms underlying RB protein function

  2013cites this paper
• Systematic Analysis of Residues in Conserved Region 3 of the Human Papillomavirus 16 E7 Oncoprotein

  2013cites this paper
• Deciphering the retinoblastoma protein phosphorylation code.

  2013cites this paper
• Changes in Protein Abundance are Essential for Proper Cell Cycle Regulation

  2013cites this paper
• Conserved Region 3 of Human Papillomavirus 16 E7 Contributes to Deregulation of the Retinoblastoma Tumor Suppressor

  2012cites this paper
• Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation.

  2012cites this paper
• The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

  2012cites this paper
• Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function.

  2012cites this paper
• Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

  2012cites this paper
• DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis

  2011cites this paper
• Scholarship@Western Scholarship@Western

  year unknowncites this paper