Titratable Acidity and Total Soluble Solid Content of Pediatric Antitussive Medicines

Adresa za dopisivanje Prof. dr. Alessandro Leite Cavalcanti Avenida Manoel Moraes, 471/802 Manaíra 58038-230 João Pessoa, PB, Brasil Tel: +55 83 3315-3326 dralessandro@ibest.com.br Sažetak Svrha: U ovoj su se eksperimentalnoj studiji in vitro procijenili endogeni pH, kiselost titracije i ukupan udjel čvrste topljive tvari (UUTČT) u pedijatrijskim antitusivnim lijekovima u obliku sirupa. Ispitanici i metode: sedam lijekova procijenjeno je u pokusu prema načelu slučajnog odabira i svaka je analiza bila ponovljena tri puta. Procjena pH-a obavljena je potenciometrijom, a ocijenjen je bio i puferski kapacitet nakon što se razrijedio svaki lijek. Inkrementi od 0,1 N KOH-a titrirani su dok nije dosegnuta neutralnost. Mjerenje UUTČT-a obavljeno je Brixovom refraktometrijom uz pomoć Abbéova refraktometra. Rezultati: vrijednosti pH-a kretale su se od 2,65 (Mucolin®) do 6,56 (Fluimucil®), a kod četiriju lijekova bile su niže od kritičnih 5,5. Vrijednosti titracijske kiselosti za te lijekove bile su od 0,061 (Fluimucil®) do 0,467 (Ambroxmel®). Fluimucil® je pokazao najnižu vrijednost UUTČT-a (4,33%), a Mucofan® je imao najveću (53,41%). Zaključak: mnogobrojni pedijatrijski antitusici imali su pH ispod kritične vrijednosti, visoke titracijske vrijednosti te veliku koncentraciju šećera, što može povećati njihov kariogeni i erozivni učinak u slučaju neodgovarajuće primjene kod djece. Ključne riječi farmaceutski pripravci; zaslađivači; primjena, oralna; erozija zuba; zubni karijes; antitusici 1 Zavod za dječju stomatologiju Stomatološkog fakulteta Sveučilišta Paraibe, Campina Grande, Brazil Department of Pediatric Dentistry, School of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil 2 Zavod za dječju stomatologiju Stomatološkog fakulteta Sveučilišta Paraibe, Campina Grande, Brazil, student Undergraduate student, Department of Pediatric Dentistry, School of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil 3 Zavod za analitičku kemiju, Kemijski fakultet Sveučilišta Paraibe, Campina Grande, Brazil Department of Analytical Chemistry, School of Chemistry, State University of Paraiba, Campina Grande, PB, Brazil

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