Different Clinically Relevant Dose Schedules Colon Cancer ( HCT-8 ) Sublines following Exposure to Two Novel Mechanism ( s ) of Resistance to 5-Fluorouracil in Human Updated

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid development of resistance to antifolates in vitro: possible clinical implication.

  1991influential reference
• Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin.

  1991cited by this paper
• Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid.

  1991cited by this paper
• Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA.

  1990cited by this paper
• Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma.

  1990cited by this paper
• The Modulation of Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma A Prospective Randomized Phase III Trial

  1990cited by this paper
• Improvements in fluorouracil chemotherapy?

  1989influential reference
• Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

  1989cited by this paper
• Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: a randomized trial of the Northern California Oncology Group.

  1989cited by this paper
• Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

  1988cited by this paper
• Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.

  1988cited by this paper
• Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.

  1988cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.

  1987cited by this paper
• Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.

  1987cited by this paper
• Tissue folate polyglutamate chain length determination by electrophoresis as thymidylate synthase-fluorodeoxyuridylate ternary complexes.

  1986cited by this paper
• Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

  1986cited by this paper
• Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.

  1985cited by this paper
• Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

  1985cited by this paper
• A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.

  1985cited by this paper
• Resistance of CCRF-CEM cloned sublines to 5-fluorodeoxyuridine associated with enhanced phosphatase activities.

  1985cited by this paper
• Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.

  1985cited by this paper
• 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity.

  1984cited by this paper
• A method for the determination of total, free, and 5-fluorodeoxyuridylate-bound thymidylate synthase in cell extracts.

  1984influential reference
• Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

  1983cited by this paper
• Fluorinated pyrimidines and their nucleosides.

  1983cited by this paper
• Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

  1983cited by this paper
• Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.

  1982cited by this paper
• In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

  1982cited by this paper
• Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro.

  1982cited by this paper
• Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal adenocarcinoma HCT-8.

  1981cited by this paper
• The pharmacology of the fluoropyrimidines.

  1981cited by this paper
• Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase.

  1981cited by this paper
• Relative affinity of 5,10-methylenetetrahydrofolylpolyglutamates for the Lactobacillus casei thymidylate synthetase-5-fluorodeoxyuridylate binary complex.

  1981cited by this paper
• Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.

  1980cited by this paper
• Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.

  1980cited by this paper
• Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.

  1979cited by this paper
• Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism.

  1978cited by this paper
• Pyrimidine nucleoside monophosphate kinase from human leukemic blast cells.

  1978cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

  1975cited by this paper
• A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant.

  1974cited by this paper
• Properties of thymidine kinase partially purified from human fetal and adult tissue.

  1972cited by this paper
• Comparative studies of fluorinated pyrimidines with various cell lines.

  1968cited by this paper
• On the action of fluorouracil on leukemia cells.

  1966cited by this paper
• Properties of deoxythymidine kinase partially purified from animal tumors.

  1965cited by this paper
• FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B.

  1963influential reference
• Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance.

  1962cited by this paper

• No citing papers are available for this paper.