Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Brain : a journal of neurology

• Publication date

  2006-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/BRAIN/AWL057PMID 16537565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Remyelination In Multiple Sclerosis

  2007cited by this paper
• Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury

  2007cited by this paper
• Early events in node of Ranvier formation during myelination and remyelination in the PNS.

  2006cited by this paper
• Olfactory ensheathing cells and spinal cord repair.

  2005cited by this paper
• Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells.

  2005cited by this paper
• Failure of Remyelination in the Nonhuman Primate Optic Nerve

  2005cited by this paper
• The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes

  2005cited by this paper
• Promoting repair in multiple sclerosis: problems and prospects

  2005cited by this paper
• Grafts of Brain-Derived Neurotrophic Factor and Neurotrophin 3-Transduced Primate Schwann Cells Lead to Functional Recovery of the Demyelinated Mouse Spinal Cord

  2005cited by this paper
• Myelin Biology and Disorders

  2004cited by this paper
• It's “juxta” potassium channel!

  2004cited by this paper
• Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin

  2004cited by this paper
• Changes in the expression of tetrodotoxin‐sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

  2004cited by this paper
• Neural Precursors as a Cell Source to Repair the Demyelinated Spinal Cord

  2004cited by this paper
• Contribution of Müller cells toward the regulation of photoreceptor outer segment assembly.

  2004cited by this paper
• Spinal cord multiple sclerosis lesions in Japanese patients: Schwann cell remyelination occurs in areas that lack glial fibrillary acidic protein (GFAP)

  2004cited by this paper
• Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies

  2004cited by this paper
• Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath.

  2004cited by this paper
• Remyelination through Engraftment

  2004cited by this paper
• The local differentiation of myelinated axons at nodes of Ranvier

  2003cited by this paper
• Molecular organization of axo-glial junctions.

  2003cited by this paper
• Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination.

  2003cited by this paper
• Paranodal Interactions Regulate Expression of Sodium Channel Subtypes and Provide a Diffusion Barrier for the Node of Ranvier

  2003influential reference
• Dysregulation of axonal sodium channel isoforms after adult‐onset chronic demyelination

  2003cited by this paper
• Myelin P0: New Knowledge and New Roles

  2002cited by this paper
• Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia.

  2002cited by this paper
• Development of nodes of Ranvier.

  2002cited by this paper
• Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion

  2002cited by this paper
• New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation

  2002cited by this paper
• Remyelination of the Rat Spinal Cord by Transplantation of Identified Bone Marrow Stromal Cells

  2002cited by this paper
• Schwann cell remyelination is not replaced by oligodendrocyte remyelination following ethidium bromide induced demyelination

  2002influential reference
• Nodes of Ranvier come of age.

  2002cited by this paper
• A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells

  2002cited by this paper
• Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis.

  2002cited by this paper
• Ezrin, radixin, and moesin are components of Schwann cell microvilli

  2001cited by this paper
• Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord

  2001cited by this paper
• Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier.

  2001influential reference
• Subunit composition and novel localization of K+ channels in spinal cord

  2001influential reference
• Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.

  2001cited by this paper
• Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes.

  2001cited by this paper
• Developmental clustering of ion channels at and near the node of Ranvier.

  2001influential reference
• Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

  2001influential reference
• Remyelination of demyelinated CNS axons by transplanted human schwann cells: the deleterious effect of contaminating fibroblasts.

  2001cited by this paper
• Remyelination of Demyelinated CNS Axons by Transplanted Human Schwann Cells: The Deleterious Effect of Contaminating Fibroblasts

  2001cited by this paper
• Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin.

  2001cited by this paper
• Developmental and regional expression of sodium channel isoform NaCh6 in the rat central nervous system

  2000cited by this paper
• Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

  2000cited by this paper
• Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses.

  2000influential reference
• Nomenclature of voltage-gated sodium channels.

  2000cited by this paper
• K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve

  1999cited by this paper
• The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination.

  1999cited by this paper
• The Structure and Function of Myelin Oligodendrocyte Glycoprotein

  1999cited by this paper
• Dependence of Nodal Sodium Channel Clustering on Paranodal Axoglial Contact in the Developing CNS

  1999cited by this paper
• Myelin Galactolipids Are Essential for Proper Node of Ranvier Formation in the CNS

  1998cited by this paper
• In vitro and in vivo behaviour of NDF‐expanded monkey Schwann cells

  1998cited by this paper
• Conduction in Segmentally Demyelinated Mammalian Central Axons

  1997cited by this paper
• Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): Different expression patterns in developing rat nervous system

  1997cited by this paper
• Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions

  1997cited by this paper
• Differential expression of sodium channel genes in retinal ganglion cells.

  1997cited by this paper
• Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.

  1997cited by this paper
• Paranodin, a glycoprotein of neuronal paranodal membranes.

  1997cited by this paper
• The Clustering of Axonal Sodium Channels during Development of the Peripheral Nervous System

  1996cited by this paper
• Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

  1996cited by this paper
• Restoration of Normal Conduction Properties in Demyelinated Spinal Cord Axons in the Adult Rat by Transplantation of Exogenous Schwann Cells

  1996cited by this paper
• Blood-brain barrier permeability in astrocyte-free regions of the central nervous system remyelinated by Schwann cells.

  1996cited by this paper
• Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS

  1995cited by this paper
• Differential distribution of closely related potassium channels in rat Schwann cells

  1995cited by this paper
• Molecular dissection of the myelinated axon

  1993cited by this paper
• Multiple sclerosis. Pathology of recurrent lesions.

  1993cited by this paper
• Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons

  1993cited by this paper
• Conduction properties of central nerve fibers remyelinated by Schwann cells.

  1992cited by this paper
• Demyelination in spinal cord injury and multiple sclerosis: what can we do to enhance functional recovery?

  1992cited by this paper
• Repair of a myelin lesion by Schwann cells transplanted in the adult mouse spinal cord.

  1992influential reference
• Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons.

  1989cited by this paper
• Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

  1987cited by this paper
• Continual Breakdown and Regeneration of Myelin in Progressive Multiple Sclerosis Plaques a

  1984cited by this paper
• Axonal physiology of chronic spinal cord injury in the cat: intracellular recording in vitro.

  1983cited by this paper
• The restoration of conduction by central remyelination.

  1981cited by this paper
• Central remyelination restores secure conduction

  1979cited by this paper
• Remyelination in multiple sclerosis

  1978cited by this paper
• Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve

  1977cited by this paper
• Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat

  1975cited by this paper
• Remyelination in multiple sclerosis with peripheral type myelin.

  1973cited by this paper
• The effects of experimental demyelination on conduction in the central nervous system.

  1970influential reference
• Brain

  1878cited by this paper

• Roles of Ion Channels in Oligodendrocyte Precursor Cells: From Physiology to Pathology

  2025cites this paper
• AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats

  2023cites this paper
• A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

  2022cites this paper
• Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging

  2021cites this paper
• Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury

  2021cites this paper
• Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain

  2021influential citation
• iPSCs and DRGs: stepping stones to new pain therapies.

  2021cites this paper
• Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?

  2021cites this paper
• Bone morphogenetic proteins: New insights into their roles and mechanisms in CNS development, pathology and repair.

  2020cites this paper
• Confabulation affecting Temporal Consciousness significantly more than Knowing Consciousness.

  2020cites this paper
• Schwann cells: Rescuers of central demyelination.

  2020cites this paper
• Cellular Senescence and Failure of Myelin Repair in Multiple Sclerosis.

  2020cites this paper
• Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System

  2020cites this paper
• Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination

  2018cites this paper
• Edinburgh Research Explorer Axonal domains

  2018cites this paper
• Confabulations and related disorders: We've come a long way, but there is still a lot to do!

  2017cites this paper
• Spike Generation and Excitable Domains in Myelinated and Demyelinated Axons

  2017cites this paper
• Mitochondrial function and dynamics in demyelinated axons

  2017cites this paper
• Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons

  2017influential citation
• Remyelination: A Potential Therapeutic Strategy for Alzheimer’s Disease?

  2017cites this paper
• Biomechanical Acclimation : Flying Cold

  2017cites this paper
• Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death

  2017cites this paper
• Adult skin-derived precursor Schwann cells exhibit superior myelination and regeneration supportive properties compared to chronically denervated nerve-derived Schwann cells.

  2016cites this paper
• Biomechanical Acclimation : Flying Cold

  2016cites this paper
• Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury

  2016cites this paper
• Neuroprotection and Recovery in Multiple Sclerosis

  2016cites this paper
• Different patterns of recollection impairment in confabulation reveal different disorders of consciousness: A multiple case study.

  2016cites this paper
• Regeneration and plasticity of descending propriospinal neurons after transplantation of Schwann cells overexpressing glial cell line-derived neurotrophic factor following thoracic spinal cord injury in adult rats

  2015cites this paper
• Adult DRG Stem/Progenitor Cells Generate Pericytes in the Presence of Central Nervous System (CNS) Developmental Cues, and Schwann Cells in Response to CNS Demyelination

  2015cites this paper
• Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease.

  2015cites this paper
• Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury.

  2015cites this paper
• Impact of Mechanotransduction in the Context of Central Nervous System Diseases

  2015cites this paper
• From demyelination to remyelination: The road toward therapies for spinal cord injury

  2015cites this paper
• Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats

  2015cites this paper
• The sodium channel isoform transition at developing nodes of ranvier in the peripheral nervous system: Dependence on a Genetic program and myelination‐induced cluster formation

  2014cites this paper
• Oligodendrocyte progenitors: adult stem cells of the central nervous system?

  2014cites this paper
• Spinal Cord Regeneration

  2014cites this paper
• Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach

  2013cites this paper
• Schwann Cells But Not Olfactory Ensheathing Cells Inhibit CNS Myelination via the Secretion of Connective Tissue Growth Factor

  2013cites this paper
• Locomotor recovery after spinal cord hemisection/contusion injures in bonnet monkeys: Footprint testing—a minireview

  2013cites this paper
• Unraveling the role of cns acidosis in experimental autoimmune encephalomyelitis

  2013influential citation
• Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

  2013cites this paper
• Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination

  2013cites this paper
• Guía de uso adecuado de modelos animales para el desarrollo de terapias en esclerosis múltiple

  2012cites this paper
• [Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis].

  2012cites this paper
• Strength-Duration Time Constant in Peripheral Nerve: No Abnormality in Multiple Sclerosis

  2012cites this paper
• Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

  2012cites this paper
• Axonal Regeneration Supported by Oligo[poly(ethylene glycol)fumarate] Cell-Loaded Hydrogel Scaffolds in the Transected Rat Spinal Cord

  2012cites this paper
• Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages

  2011cites this paper
• Alterations of action potentials and the localization of Nav1.6 sodium channels in spared axons after hemisection injury of the spinal cord in adult rats.

  2011cites this paper
• Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments.

  2011cites this paper
• Ionenkanalmodulatoren bei Multipler Sklerose

  2011cites this paper
• [Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].

  2011cites this paper
• Ion channels in autoimmune neurodegeneration

  2011cites this paper
• Principles of Translation of Biologic Therapies in Spinal Cord Injury

  2011cites this paper
• Boundary Cap Cells are Highly Competitive for CNS Remyelination: Fast Migration and Efficient Differentiation in PNS and CNS Myelin‐Forming Cells

  2010cites this paper
• Role of Chondroitin Sulfate Proteoglycans in Axonal Conduction in Mammalian Spinal Cord

  2010cites this paper
• Confabulation in Alzheimer’s disease and amnesia: A qualitative account and a new taxonomy

  2010cites this paper
• Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

  2009cites this paper
• Towards personalized cell-replacement therapies for brain repair.

  2009cites this paper
• Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.

  2009cites this paper
• Confabulation in Alzheimer's disease: poor encoding and retrieval of over-learned information.

  2009cites this paper
• Supraspinal Sensory Perception after Spinal Cord Injury and the Modulatory Factors Associated with Below-Level Allodynia

  2009cites this paper
• Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fibers to motoneurons.

  2009cites this paper
• "Do you remember what you did on March 13, 1985?" A case study of confabulatory hypermnesia.

  2009cites this paper
• Enhancing the ability of experimental autoimmune encephalomyelitis to serve as a more rigorous model of multiple sclerosis through refinement of the experimental design.

  2009cites this paper
• Positive Trafficking Pathways of a Voltage Gated Potassium Channel

  2009cites this paper
• Ectopic expression of polysialylated neural cell adhesion molecule in adult macaque Schwann cells promotes their migration and remyelination potential in the central nervous system

  2009cites this paper
• Schwann cell transplantation for CNS repair.

  2008cites this paper
• From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases

  2008cites this paper
• Biomechanical acclimation: flying cold.

  2008cites this paper
• MULTIPLE SCLEROSIS: REMYELINATION

  2008cites this paper
• Axonal domains: role for paranodal junction in node of Ranvier assembly.

  2008cites this paper
• Remyelination In Multiple Sclerosis

  2007cites this paper
• Toward the development of rational therapies in multiple sclerosis: what is on the horizon?

  2007cites this paper
• Schwann cells and their precursors for repair of central nervous system myelin.

  2007cites this paper
• Remyelination of the Central Nervous System: A Valuable Contribution from the Periphery

  2007cites this paper
• Sodium Channels and Multiple Sclerosis: Roles in Symptom Production, Damage and Therapy

  2007cites this paper
• Cellular approaches for stimulating CNS remyelination.

  2007cites this paper
• Myelination of Congenitally Dysmyelinated Spinal Cord Axons by Adult Neural Precursor Cells Results in Formation of Nodes of Ranvier and Improved Axonal Conduction

  2007cites this paper
• Duke University Dissertation Template

  2007cites this paper
• Remyelination of the Central Nervous System

  2007cites this paper
• 22 – Multiple Sclerosis as a Neurodegenerative Disease

  2007cites this paper
• Animal models for cell and gene therapy in myelin disease

  2006cites this paper
• Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegeneration.

  2006cites this paper
• Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis.

  2006cites this paper
• Edinburgh Research Explorer Axonal domains

  year unknowncites this paper