Aldosterone plays a pivotal role in the pathogenesis of thrombotic microangiopathy in SHRSP.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of the American Society of Nephrology

• Publication date

  2003-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/01.ASN.0000078960.15147.05PMID 12874452
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension

  2004cited by this paper
• Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension

  2004cited by this paper
• Aldosterone as a Mediator in Cardiovascular Injury

  2002cited by this paper
• Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.

  2002cited by this paper
• Mineralocorticoid Receptor Affects AP-1 and Nuclear Factor-&kgr;B Activation in Angiotensin II–Induced Cardiac Injury

  2001cited by this paper
• Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton.

  2001cited by this paper
• Aldosterone and the hypertensive kidney: its emerging role as a mediator of progressive renal dysfunction: a paradigm shift

  2001cited by this paper
• Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure.

  2000cited by this paper
• Aldosterone: a mediator of myocardial necrosis and renal arteriopathy.

  2000cited by this paper
• Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.

  2000cited by this paper
• Blood pressure-independent effects in rats with human renin and angiotensinogen genes.

  2000cited by this paper
• Effect of Angiotensin II Blockade on Renal Injury in Mineralocorticoid-Salt Hypertension

  2000cited by this paper
• Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats.

  1998cited by this paper
• B001: Mineralocorticoid antagonism reduces ANG-II induced renal injury in stroke-prone hypertensive rats

  1998cited by this paper
• Regional renal nitric oxide release in stroke-prone spontaneously hypertensive rats.

  1997cited by this paper
• Malignant vascular disease of the kidney: nature of the lesions, mediators of disease progression, and the case for bilateral nephrectomy.

  1996cited by this paper
• Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta.

  1995cited by this paper
• Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease.

  1995cited by this paper
• Production of aldosterone in isolated rat blood vessels.

  1995cited by this paper
• Contribution of renal angiotensin II type I receptor to gene expressions in hypertension-induced renal injury.

  1994cited by this paper
• Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.

  1994cited by this paper
• Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

  1993cited by this paper
• Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade

  1993cited by this paper
• Adrenalectomy ameliorates ablative nephropathy in the rat independently of corticosterone maintenance level.

  1992cited by this paper
• The antiproteinuric action of enalapril in stroke-prone spontaneously hypertensive rats is unrelated to alterations in urinary prostaglandins.

  1992cited by this paper
• Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor.

  1992cited by this paper
• Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect.

  1991influential reference
• Vasoconstrictor effect of angiotensin and vasopressin in isolated rabbit afferent arterioles.

  1991cited by this paper
• Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension.

  1990cited by this paper
• Enalapril Prevents Stroke and Kidney Dysfunction in Salt‐Loaded Stroke‐Prone Spontaneously Hypertensive Rats

  1989cited by this paper
• Regulation of aldosterone secretion.

  1988influential reference
• Serum aldosterone and protein-binding variables in Yanomama Indians: a no-salt culture as compared to partially acculturated Guaymi Indians.

  1985cited by this paper
• Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney.

  1985cited by this paper
• Renin-angiotensin system in stroke-prone spontaneously hypertensive rats.

  1979cited by this paper
• Accelerated hypertension in the rat: relation between renin, renal vascular lesions, salt intake and blood pressure.

  1976cited by this paper
• Renal abnormalities and vascular complications in primary hyperaldosteronism. Evidence on tertiary hyperaldosteronism.

  1976cited by this paper
• Effects of saline drinking on malignant course of renal hypertension in rats.

  1976cited by this paper
• Malignant Hypertension Resulting from Deoxycorticosterone Acetate and Salt Excess: ROLE OF RENIN AND SODIUM IN VASCULAR CHANGES

  1975cited by this paper
• Malignant hypertension with aldosteronoma producing adenoma.

  1974cited by this paper
• THE RELATIONSHIP OF HYPERTENSION AND RENAL FAILURE IN SCLERODERMA (PROGRESSIVE SYSTEMIC SCLEROSIS) TO STRUCTURAL AND FUNCTIONAL ABNORMALITIES OF THE RENAL CORTICAL CIRCULATION

  1974cited by this paper
• Effects of Angiotensin II and Some Analogues on Vascular Permeability in the Rabbit

  1972cited by this paper
• CLINICAL CHARACTERISTICS OF PRIMARY ALDOSTERONISM FROM AN ANALYSIS OF 145 CASES.

  1964cited by this paper
• PRIMARY ALDOSTERONISM WITH MALIGNANT HYPERTENSION.

  1963cited by this paper
• Malignant Hypertension Produced by Treatment with Desoxycorticosterone Acetate and Sodium Chloride.

  1943cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy*

  year unknowncited by this paper
• Downloaded from http://hyper.ahajournals.org / by guest on February 21, 2013Role of Aldosterone in Renal Vascular Injury in Stroke-Prone Hypertensive Rats

  year unknowncited by this paper

• Occurrence of Metabolic Disorders in Bilateral Primary Aldosteronism Compared to Unilateral Primary Aldosteronism

  2025cites this paper
• Role of aldosterone in various target organ damage in patients with hypertensive emergency: a cross-sectional study

  2024cites this paper
• Impact of early initiation of renin-angiotensin blockade on renal function and clinical outcomes in patients with hypertensive emergency: a retrospective cohort study

  2023cites this paper
• Lowering of blood pressure by chemical ablation of the unilateral adrenal gland in spontaneously hypertensive rats

  2023cites this paper
• Unilateral chemical ablation of the adrenal gland lowers blood pressure and alleviates target organ damage in spontaneously hypertensive rats

  2023cites this paper
• Aldosterone and cardiovascular diseases.

  2022cites this paper
• Mineralocorticoid receptor antagonism improves transient receptor potential vanilloid 4-dependent dilation of cerebral parenchymal arterioles and cognition in a genetic model of hypertension

  2022cites this paper
• Hyperglycemia Potentiates Prothrombotic Effect of Aldosterone in a Rat Arterial Thrombosis Model

  2021cites this paper
• To Curb the Progression of Fatal COVID-19 Course—Dream or Reality

  2021cites this paper
• Primary Hyperaldosteronism: A Rare Cause of Malignant Hypertension with Thrombotic Microangiopathy in a Kidney Transplant Recipient

  2021cites this paper
• Commentary: Expression of exogenous epithelial sodium channel beta subunit in the mouse middle cerebral artery increases pressure-induced constriction.

  2021cites this paper
• Enhanced Thrombotic Responses Are Associated With Striatin Deficiency and Aldosterone

  2021cites this paper
• Mineralocorticoid Receptor Blockers: Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

  2020cites this paper
• Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells

  2020cites this paper
• Aldosterone and Myocardial Pathology.

  2019cites this paper
• Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome

  2019cites this paper
• Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology

  2018cites this paper
• Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol.

  2017cites this paper
• New agents modulating the renin-angiotensin-aldosterone system—Will there be a new therapeutic option?

  2016cites this paper
• A Case Report of Thrombotic Microangiopathic Malignant Hypertension

  2015cites this paper
• Systemic Aldosterone, But Not Angiotensin II, Plays a Pivotal Role in the Pathogenesis of Renal Injury in Chronic Nitric Oxide-Deficient Male Rats.

  2015cites this paper
• Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage

  2014cites this paper
• Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation.

  2012cites this paper
• Effect of Spironolactone on Chronic Allograft Nephropathy in Rats

  2012cites this paper
• Is the Spontaneously Hypertensive Stroke Prone Rat a Pertinent Model of Sub Cortical Ischemic Stroke? A Systematic Review

  2011cites this paper
• Study of the mechanisms of aldosterone prothrombotic effect in rats

  2011cites this paper
• Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease.

  2011cites this paper
• [Aldosterone and kidney diseases: an emergent paradigm with important clinical implications].

  2011cites this paper
• Clinical Features of Malignant Hypertension with Thrombotic Microangiopathy

  2011cites this paper
• Endocrinological aspects of proteinuria and podocytopathy in diabetes: role of the aldosterone/mineralocorticoid receptor system.

  2011cites this paper
• Captopril Treatment Temporarily Restores Cerebral Blood Flow Autoregulation in Spontaneously Hypertensive Rats After Hemorrhagic Stroke

  2010cites this paper
• Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome

  2010cites this paper
• Amlodipine suppressed cardiac gene expression of brain natriuretic peptide, transforming growth factor‐β1 and fibronectin mediated by aldosterone in male stroke‐prone spontaneously hypertensive rats

  2010cites this paper
• [Prothrombotic aldosterone action--a new side of the hormone].

  2010cites this paper
• Mineralocorticoid receptors in myocardial infarction.

  2009cites this paper
• Growth Arrest Specific Protein 6 Participates in DOCA-Induced Target-Organ Damage

  2009cites this paper
• Aldosterone, a vasculotoxic agent--novel functions for an old hormone.

  2009cites this paper
• Central Mineralocorticoid Receptors and Cardiovascular Disease

  2009cites this paper
• Effects of prenatal and postnatal nutritional environment on the onset of cerebrovascular disorders in stroke-prone spontaneously hypertensive rats

  2009cites this paper
• Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive rats.

  2008influential citation
• Rôles physiopathologiques des récepteurs corticostéroïdes dans le rein et dans l'endothélium vasculaire : apports des modèles conditionnels transgéniques

  2008cites this paper
• Aldosterone as an Independent Factor in Cerebrovascular Damage

  2008cites this paper
• Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension.

  2008cites this paper
• Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage.

  2008cites this paper
• Primary aldosteronism and aldosterone-associated hypertension

  2008cites this paper
• Hypertension artérielle maligne

  2007cites this paper
• Thrombotic microangiopathy in the intensive care unit: need for strict control of blood pressure.

  2007cites this paper
• spontaneously hypertensive rats factors in kidney of adrenalectomized stroke-prone Aldosterone , but not angiotensin II , increases profibrotic

  2007influential citation
• Mineralocorticoid receptor activation and cardiac fibrosis.

  2007cites this paper
• Importance of realistic sample size calculations and why the next randomized trial needs to be large and multicentered

  2007cites this paper
• The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension.

  2007cites this paper
• Renal Thrombotic Microangiopathy in a Genetic Model of Hypertension in Mice

  2006cites this paper
• Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats.

  2005cites this paper
• Chapter 12 – Aldosterone and Mineralocorticoids

  2005cites this paper
• Śródbłonkowe działanie aldosteronu - implikacje terapeutyczne płynące z badań podstawowych i klinicznych

  2005cites this paper
• Aldosterone Synthase Inhibitor Ameliorates Angiotensin II–Induced Organ Damage

  2005cites this paper
• Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats

  2005cites this paper
• Aldosterone in heart and kidney diseases.

  2005cites this paper
• Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?

  2005cites this paper
• Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells.

  2005cites this paper
• Effect of Aldosterone and MR Blockade on the Brain and the Kidney

  2005cites this paper
• Rôles physiopathologiques de l'aldostérone : Apport des modèles animaux

  2005cites this paper
• [Old and new drugs to block aldosterone and ameliorate cardiovascular disease].

  2004cites this paper
• Complications of the nephrotic syndrome and their treatment.

  2004cites this paper
• Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats.

  2004cites this paper
• (Alte) Neue Medikamente: Aldosteron-Antagonisten zur Behandlung kardiovaskulärer und nephrologischer Erkrankungen

  2004cites this paper
• Target Organ Damage

  2003cites this paper
• Impact of early initiation of renin-angiotensin blockade on renal function and prognosis in patients with hypertensive emergency: A retrospective cohort study

  year unknowncites this paper