Pharmacokinetics of cladribine in plasma and its 5'-monophosphate and 5'-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Clinical Cancer Research

• Publication date

  1998-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9533533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prognostic factors

  1998cited by this paper
• Intermittent infusion of cladribine (CdA) in previously treated patients with low-grade non-Hodgkin's lymphoma.

  1997cited by this paper
• 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on cellular mitochondrial function.

  1997cited by this paper
• Pharmacokinetic study of oral and bolus intravenous 2-chlorodeoxyadenosine in patients with malignancy.

  1996cited by this paper
• Treatment of multiple sclerosis and other autoimmune diseases with cladribine.

  1996cited by this paper
• Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions.

  1996cited by this paper
• Determination of 2-chloro-2'-deoxyadenosine nucleotides in leukemic cells by ion-pair high-performance liquid chromatography.

  1996cited by this paper
• The treatment of chronic progressive multiple sclerosis with cladribine.

  1996cited by this paper
• Cellular pharmacokinetics of 2-chloro-2'-deoxyadenosine nucleotides: comparison of intermittent and continuous intravenous infusion and subcutaneous and oral administration in leukemia patients

  1995cited by this paper
• Treatment of Waldenstrom's macroglobulinemia resistant to standard therapy with 2-chlorodeoxyadenosine: identification of prognostic factors.

  1995cited by this paper
• Comparison of antitumor activities of 2-chlorodeoxyadenosine and 9-beta-arabinosyl-2-fluoroadenine in chronic lymphocytic leukemia and marrow cells in vitro.

  1995cited by this paper
• Purine analogs in the treatment of low-grade lymphomas and chronic lymphocytic leukemias.

  1995influential reference
• Kinetics and metabolism of 2-chloro-2′-deoxyadenosine and 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine in the isolated perfused rat liver

  1995cited by this paper
• Subcutaneous injections of 2-chlorodeoxyadenosine for symptomatic hairy cell leukemia.

  1995cited by this paper
• Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues.

  1995cited by this paper
• 2-Chlorodeoxyadenosine-Induced Complete Remissions in Langerhans-Cell Histiocytosis

  1994cited by this paper
• Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia.

  1994cited by this paper
• Pharmacokinetics of cladribine (2-chlorodeoxyadenosine) in children with acute leukemia.

  1994cited by this paper
• Phosphorylation of 2‐chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients

  1994cited by this paper
• Analysis of 2‐Chloro‐2'‐Deoxyadenosine in Human Blood Plasma and Urine by High‐Performance Liquid Chromatography Using Solid‐Phase Extraction

  1994cited by this paper
• Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine.

  1993cited by this paper
• Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine.

  1993cited by this paper
• On the bioavailability of 2-chloro-2′-deoxyadenosine (CdA)

  1993cited by this paper
• Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine

  1993cited by this paper
• Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine.

  1993cited by this paper
• High complete remission rate from 2-chloro-2'-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count.

  1993influential reference
• 2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia.

  1992cited by this paper
• Base-Modified Nucleosides Related to 2-Chloro-2′-deoxyadenosine

  1992cited by this paper
• Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine.

  1992influential reference
• On the bioavailability of oral and subcutaneous 2-chloro-2'-deoxyadenosine in humans: alternative routes of administration.

  1992cited by this paper
• Cladribine (2-chlorodeoxyadenosine)

  1992cited by this paper
• On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans.

  1991cited by this paper
• A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia.

  1991cited by this paper
• Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice.

  1989cited by this paper
• Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells.

  1989cited by this paper
• Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute‐sponsored working group

  1988cited by this paper
• Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase.

  1988cited by this paper
• Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

  1985cited by this paper
• Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

  1980cited by this paper
• Synthesis and biological activity of selected 2,6-disubstituted-(2-deoxy- -and- -D-erythro-pentofuranosyl)purines.

  1972cited by this paper
• Synthesis and biological activity of selected 2,6-disubstituted(2-deoxy-.alpha.- and -.beta.-D-erythro-pentofuranosyl)purines

  1972cited by this paper

• Synthesis of Triphosphate Nucleoside Prodrugs: γ‐ProTriPs

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  2024cites this paper
• Treatment of Classic Hairy Cell Leukemia: Targeting Minimal Residual Disease beyond Cladribine

  2022cites this paper
• Is Monitoring of the Intracellular Active Metabolite Levels of Nucleobase and Nucleoside Analogs Ready for Precision Medicine Applications?

  2022cites this paper
• Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues

  2020cites this paper
• Randomized Phase II Study of First-Line Cladribine With Concurrent or Delayed Rituximab in Patients With Hairy Cell Leukemia.

  2020cites this paper
• The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis

  2018cites this paper
• Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium.

  2017cites this paper
• Revisiting the role of cladribine in acute myeloid leukemia: An improvement on past accomplishments or more old news?

  2015cites this paper
• Prediction of Drug Distribution in Rat and Humans Using an Artificial Neural Networks Ensemble and a PBPK Model

  2014cites this paper
• 2‐Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte‐derived dendritic cells

  2013cites this paper
• Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine

  2013cites this paper
• Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines

  2011cites this paper
• Investigation of the effects of adenosine and purine nucleoside analogues on the viability of human breast cancer cells

  2010cites this paper
• The role of 5'-nucleotidases and Deoxynucleoside Kinases in Responses to Nucleoside Analogues

  2010cites this paper
• The cladribine conundrum: deciphering the drug's mechanism of action

  2010cites this paper
• Nucleoside analog cytotoxicity ‐focus on enzyme regulation, metabolism, and development of resistance

  2010cites this paper
• Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.

  2010cites this paper
• Mechanisms of anti-cancer action and pharmacology of clofarabine.

  2009cites this paper
• Cladribine: not just another purine analogue?

  2009cites this paper
• Concomitant treatment with lamivudine renders cladribine inactive by inhibition of its phosphorylation

  2009cites this paper
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  2008cites this paper
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  2008cites this paper
• Effect of Frequently Used Chemotherapeutic Drugs on Cytotoxic Activity of Human Cytotoxic T-lymphocytes

  2008cites this paper
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• Hodgkin-lymphoma-derived cells show high sensitivity to dactinomycin and paclitaxel

  2007cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper