Development of a New Technique for the Efficient Delivery of Aerosolized Medications to Infants on Mechanical Ventilation

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Pharmaceutical Research

• Publication date

  2014-08-08

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1007/s11095-014-1466-4PMID 25103332PMCID PMC4286504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Aerosol therapy in children.

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