Estradiol Suppresses Glutamatergic Transmission to Gonadotropin-Releasing Hormone Neurons in a Model of Negative Feedback in Mice1

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biology of Reproduction

• Publication date

  2009-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1095/biolreprod.108.075077PMID 19176881PMCID PMC2804800
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of A‐Type γ‐Amino Butyric Acid Receptors Excites Gonadotrophin‐Releasing Hormone Neurones Isolated from Adult Rats

  2008cited by this paper
• Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons.

  2008cited by this paper
• Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing.

  2008cited by this paper
• Synaptic integration in hypothalamic gonadotropin releasing hormone (GnRH) neurons.

  2008cited by this paper
• Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation.

  2008cited by this paper
• Vasoactive intestinal polypeptide can excite gonadotropin-releasing hormone neurons in a manner dependent on estradiol and gated by time of day.

  2008cited by this paper
• Direct measurement of somatic voltage clamp errors in central neurons

  2008cited by this paper
• Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis

  2007cited by this paper
• Estradiol Induces Diurnal Shifts in GABA Transmission to Gonadotropin-Releasing Hormone Neurons to Provide a Neural Signal for Ovulation

  2007influential reference
• The Origin of Quantal Size Variation: Vesicular Glutamate Concentration Plays a Significant Role

  2007cited by this paper
• Novel Localization of NMDA Receptors Within Neuroendocrine Gonadotropin-Releasing Hormone Terminals

  2007cited by this paper
• Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

  2006cited by this paper
• Expression of AMPA Receptor Subunits (GluR1–GluR4) in Gonadotrophin‐Releasing Hormone Neurones of Young and Middle‐Aged Persistently Oestrous Rats During the Steroid‐Induced Luteinising Hormone Surge

  2006influential reference
• Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility.

  2006cited by this paper
• Dendritic processing of excitatory synaptic input in hypothalamic gonadotropin releasing-hormone neurons.

  2006cited by this paper
• Physiologic Regulation of a Tetrodotoxin-Sensitive Sodium Influx That Mediates a Slow Afterdepolarization Potential in Gonadotropin-Releasing Hormone Neurons: Possible Implications for the Central Regulation of Fertility

  2006cited by this paper
• Endogenous Activation of Metabotropic Glutamate Receptors Modulates GABAergic Transmission to Gonadotropin-Releasing Hormone Neurons and Alters Their Firing Rate: A Possible Local Feedback Circuit

  2005cited by this paper
• GABAergic Integration of Progesterone and Androgen Feedback to Gonadotropin-Releasing Hormone Neurons1

  2005cited by this paper
• Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity

  2005influential reference
• Endogenous γ-Aminobutyric Acid Can Excite Gonadotropin-Releasing Hormone Neurons

  2005cited by this paper
• Endogenous gamma-aminobutyric acid can excite gonadotropin-releasing hormone neurons.

  2005cited by this paper
• Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder.

  2004cited by this paper
• Identification of Neurones in the Female Rat Hypothalamus That Express Oestrogen Receptor‐Alpha and Vesicular Glutamate Transporter‐2

  2004cited by this paper
• γ-Aminobutyric Acid Neurons Integrate and Rapidly Transmit Permissive and Inhibitory Metabolic Cues to Gonadotropin-Releasing Hormone Neurons

  2004cited by this paper
• Dual-Phenotype GABA/Glutamate Neurons in Adult Preoptic Area: Sexual Dimorphism and Function

  2004influential reference
• Gamma-aminobutyric acid neurons integrate and rapidly transmit permissive and inhibitory metabolic cues to gonadotropin-releasing hormone neurons.

  2004cited by this paper
• Expression of vesicular glutamate transporter-2 in gonadotropin-releasing hormone neurons of the adult male rat.

  2004influential reference
• Endogenous GABA release inhibits the firing of adult gonadotropin-releasing hormone neurons.

  2004cited by this paper
• Control of firing by small (S)-α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid-like inputs in hypothalamic gonadotropin releasing-hormone (GnRH) neurons

  2004cited by this paper
• Direct and Indirect Regulation of Gonadotropin-Releasing Hormone Neurons by Estradiol1

  2003cited by this paper
• Metabolic Regulation of Fertility through Presynaptic and Postsynaptic Signaling to Gonadotropin-Releasing Hormone Neurons

  2003influential reference
• Distribution of vesicular glutamate transporter-2 messenger ribonucleic Acid and protein in the septum-hypothalamus of the rat.

  2003cited by this paper
• A targeted extracellular approach for recording long-term firing patterns of excitable cells: a practical guide

  2003cited by this paper
• Evidence for estrogenic regulation of gonadotropin‐releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter‐2

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Synaptic activity in chronically injured, epileptogenic sensory-motor neocortex.

  2002cited by this paper
• Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse.

  2002cited by this paper
• Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons.

  2002cited by this paper
• Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-Releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein

  2002cited by this paper
• Estradiol feedback alters potassium currents and firing properties of gonadotropin-releasing hormone neurons.

  2002cited by this paper
• Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neurons.

  2002cited by this paper
• Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse

  2001cited by this paper
• Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain.

  2001cited by this paper
• Estrogen Receptor-β Immunoreactivity in Luteinizing Hormone-Releasing Hormone Neurons of the Rat Brain.

  2001cited by this paper
• Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology.

  2000cited by this paper
• Detection of Estrogen Receptor α and β Messenger Ribonucleic Acids in Adult Gonadotropin-Releasing Hormone Neurons1.

  1999cited by this paper
• GABA- and Glutamate-Activated Channels in Green Fluorescent Protein-Tagged Gonadotropin-Releasing Hormone Neurons in Transgenic Mice

  1999influential reference
• Estrogen receptor null mice: what have we learned and where will they lead us?

  1999cited by this paper
• Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neurons.

  1999cited by this paper
• Activity-dependent modulation of synaptic AMPA receptor accumulation.

  1998cited by this paper
• Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons.

  1998cited by this paper
• Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude.

  1997cited by this paper
• Interneurons in area CA1 stratum radiatum and stratum oriens remain functionally connected to excitatory synaptic input in chronically epileptic animals.

  1997cited by this paper
• Regulation of gonadotropin-releasing hormone and luteinizing hormone secretion by AMPA receptors. Evidence for a physiological role of AMPA receptors in the steroid-induced luteinizing hormone surge.

  1997cited by this paper
• Ovarian Steroid Regulation of Estrogen and Progesterone Receptor Messenger Ribonucleic Acid in the Anteroventral Periventricular Nucleus of the Rat

  1996cited by this paper
• Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex.

  1996cited by this paper
• Amino acid-mediated regulation of spontaneous synaptic activity patterns in the rat basolateral amygdala.

  1996cited by this paper
• Preoptic rather than mediobasal hypothalamic amino acid neurotransmitter release regulates GnRH secretion during the estrogen-induced LH surge in the ovariectomized rat.

  1995cited by this paper
• Estrogen-receptive neurons in the anteroventral periventricular nucleus are synaptic targets of the suprachiasmatic nucleus and peri-suprachiasmatic region.

  1995cited by this paper
• Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties.

  1994cited by this paper
• JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements.

  1994cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• Preovulatory gonadotropin-releasing hormone surge in ovarian-intact rhesus macaques.

  1993cited by this paper
• Differential contributions of ovarian and extraovarian factors to age-related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL/6J mice.

  1992cited by this paper
• Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit.

  1992cited by this paper
• Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge.

  1991cited by this paper
• Endogenous excitatory amino acid involvement in the preovulatory and steroid-induced surge of gonadotropins in the female rat.

  1991cited by this paper
• Endogenous excitatory amino acid neurotransmission regulates the estradiol-induced LH surge in ovariectomized rats.

  1990cited by this paper
• Central actions of ovarian steroids in the feedback regulation of pulsatile secretion of luteinizing hormone.

  1987cited by this paper
• Magnesium gates glutamate-activated channels in mouse central neurones

  1984influential reference
• Discrete lesions reveal functional heterogeneity of suprachiasmatic structures in regulation of gonadotropin secretion in the female rat.

  1982cited by this paper
• Luteinizing hormone releasing factor in pituitary stalk plasma from long-term ovariectomized rats: effects of steroids.

  1980cited by this paper
• Gonadotropin-releasing hormone surge in pro-oestrous rats

  1976cited by this paper
• A daily signal for the LH surge in the rat.

  1975cited by this paper
• Estrogen-Dependent Twenty-four-Hour Periodicity in Pituitary LH Release in the Female Hamster1

  1973cited by this paper
• Estrogen-dependent 24-hour periodicity in pituitary LH release in the female hamster.

  1973cited by this paper
• The mechanism of the induction of ovulation by oestrogens.

  1965cited by this paper
• ReportPathway-Specific Trafficking of Native AMPARs by In Vivo Experience

  year unknowncited by this paper

• Altered Electrophysiology and Transcriptome of GnRH Neurons in Middle-Aged Female Mice

  2025cites this paper
• Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption

  2022influential citation
• The electrophysiologic properties of gonadotropin‐releasing hormone neurons

  2021cites this paper
• Central aspects of systemic oestradiol negative‐ and positive‐feedback on the reproductive neuroendocrine system

  2020cites this paper
• A CRH receptor type 1 agonist increases GABA transmission to GnRH neurons in a circulating-estradiol-dependent manner.

  2020cites this paper
• Differential Roles of Hypothalamic AVPV and Arcuate Kisspeptin Neurons in Estradiol Feedback Regulation of Female Reproduction

  2019cites this paper
• Changes in Both Neuron Intrinsic Properties and Neurotransmission Are Needed to Drive the Increase in GnRH Neuron Firing Rate during Estradiol-Positive Feedback

  2019cites this paper
• Estradiol Increases Glutamate and GABA Neurotransmission into GnRH Neurons via Retrograde NO-Signaling in Proestrous Mice during the Positive Estradiol Feedback Period

  2018cites this paper
• Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice

  2018cites this paper
• Identification of Genes Enriched in GnRH Neurons by Translating Ribosome Affinity Purification and RNAseq in Mice.

  2018cites this paper
• Effects of 17β estradiol and glucagon-like peptide-1 on gonadotropin-releasing hormone neurons in mice

  2018cites this paper
• Electrophysiology of Rodent GnRH Neurons

  2018cites this paper
• Mapping GABA and glutamate inputs to gonadotrophin‐releasing hormone neurones in male and female mice

  2018cites this paper
• Glutamatergic Transmission to Hypothalamic Kisspeptin Neurons Is Differentially Regulated by Estradiol through Estrogen Receptor α in Adult Female Mice

  2018cites this paper
• Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka

  2018cites this paper
• Changes in GABAergic Transmission to and Intrinsic Excitability of Gonadotropin-Releasing Hormone (GnRH) Neurons during the Estrous Cycle in Mice

  2018cites this paper
• Effect of Environmental Toxicants on the Neuroendocrine Control of Female Reproduction

  2018cites this paper
• Dissecting the ontogeny and functional relevance of altered GABAergic circuitry in Polycystic Ovary Syndrome (PCOS)

  2018cites this paper
• Non-genomic action of vitamin D3 on N-methyl-D-aspartate and kainate receptor-mediated actions in juvenile gonadotrophin-releasing hormone neurons.

  2017cites this paper
• J Gynecol 2017, 2(1): 000130

  2017cites this paper
• Continuous Kisspeptin Administration in Postmenopausal Women: Impact of Estradiol on Luteinizing Hormone Secretion

  2017cites this paper
• Dynamics of GnRH Neuron Ionotropic GABA and Glutamate Synaptic Receptors Are Unchanged during Estrogen Positive and Negative Feedback in Female Mice

  2017influential citation
• 3.18 – Neurophysiology of Gonadotropin-Releasing Hormone Neurons

  2017cites this paper
• Differential Gene Expression in Gonadotropin-Releasing Hormone Neurons of Male and Metestrous Female Mice

  2015cites this paper
• Expression of ESR1 in Glutamatergic and GABAergic Neurons Is Essential for Normal Puberty Onset, Estrogen Feedback, and Fertility in Female Mice

  2015cites this paper
• Dehydroepiandrosterone, its metabolites and ion channels.

  2015cites this paper
• Neuroendocrine Control of the Ovarian Cycle of the Rat

  2015cites this paper
• Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network

  2015cites this paper
• Puberty in Mice and Rats

  2015cites this paper
• Neurobiological Study of Fish Brains Gives Insights into the Nature of Gonadotropin-Releasing Hormone 1–3 Neurons

  2013influential citation
• Epigenetic Control of Female Puberty

  2013cites this paper
• In Vivo Recordings of GnRH Neuron Firing Reveal Heterogeneity and Dependence upon GABAA Receptor Signaling

  2013cites this paper
• Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons.

  2012cites this paper
• Circadian Control of Neuroendocrine Circuits Regulating Female Reproductive Function

  2012cites this paper
• Orexin a suppresses gonadotropin-releasing hormone (GnRH) neuron activity in the mouse.

  2012cites this paper
• Rapid Nongenomic Effects of Oestradiol on Gonadotrophin‐Releasing Hormone Neurones

  2012cites this paper
• Understanding calcium homeostasis in postnatal gonadotropin-releasing hormone neurons using cell-specific Pericam transgenics.

  2012cites this paper
• GLUTAMATERGIC AND GABAERGIC INNERVATION OF HUMAN GONADOTROPIN-1 RELEASING HORMONE-I NEURONS 2 Abbreviated title : Glutamate and GABA in inputs to GnRH neurons 3

  2012influential citation
• Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge.

  2011cites this paper
• GnRH neuron electrophysiology: a decade of study

  2011cites this paper
• Voltage-Gated Potassium Currents Are Targets of Diurnal Changes in Estradiol Feedback Regulation and Kisspeptin Action on Gonadotropin-Releasing Hormone Neurons in Mice1

  2011cites this paper
• Circadian control of kisspeptin and a gated GnRH response mediate the preovulatory luteinizing hormone surge.

  2011cites this paper
• Depolarising and Hyperpolarising Actions of GABAA Receptor Activation on Gonadotrophin‐Releasing Hormone Neurones: Towards an Emerging Consensus

  2011cites this paper
• Frequency-Dependent Recruitment of Fast Amino Acid and Slow Neuropeptide Neurotransmitter Release Controls Gonadotropin-Releasing Hormone Neuron Excitability

  2011cites this paper
• RFamide Peptides and Ovulation: Circadian Control and Environmental Disruptors

  2011cites this paper
• Identified GnRH neuron electrophysiology: a decade of study.

  2010cites this paper
• The food contaminant semicarbazide acts as an endocrine disrupter: Evidence from an integrated in vivo/in vitro approach.

  2010cites this paper
• The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges.

  2010cites this paper
• Diurnal In Vivo and Rapid In Vitro Effects of Estradiol on Voltage-Gated Calcium Channels in Gonadotropin-Releasing Hormone Neurons

  2010cites this paper
• A REPRODUKCIÓT SZABÁLYOZÓ HIPOTALAMIKUS NEURONHÁLÓZAT MORFOLÓGIAI ÉS FUNKCIONÁLIS JELLEMZÉSE

  2010cites this paper
• Glutamate regulation of GnRH neuron excitability.

  2010cites this paper
• Gamma-aminobutyric acid and glutamate differentially regulate intracellular calcium concentrations in mouse gonadotropin-releasing hormone neurons.

  2010cites this paper
• Retrograde Endocannabinoid Signaling Reduces GABAergic Synaptic Transmission to Gonadotropin-Releasing Hormone Neurons

  2010cites this paper
• Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in an estradiol-dependent manner.

  2010cites this paper
• Neurobiological Mechanisms Underlying Oestradiol Negative and Positive Feedback Regulation of Gonadotrophin‐Releasing Hormone Neurones

  2009cites this paper
• GABAergic Transmission to Gonadotropin-Releasing Hormone (GnRH) Neurons Is Regulated by GnRH in a Concentration-Dependent Manner Engaging Multiple Signaling Pathways

  2009cites this paper
• Differential Regulation of Gonadotropin-Releasing Hormone Neuron Activity and Membrane Properties by Acutely Applied Estradiol: Dependence on Dose and Estrogen Receptor Subtype

  2009cites this paper