The calcium‐dependent protein kinase (CDPK) and CDPK‐related kinase gene families in Hevea brasiliensis—comparison with five other plant species in structure, evolution, and expression

Calcium‐dependent protein kinases (CDPKs or CPKs) play important roles in various physiological processes of plants, including growth and development, stress responses and hormone signaling. Although the CDPK gene family has been characterized in several model plants, little is known about this gene family in Hevea brasiliensis (the Para rubber tree). Here, we characterize the entire H. brasiliensis CDPK and CDPK‐related kinase (CRK) gene families comprising 30 CDPK genes (HbCPK1 to 30) and nine CRK genes (HbCRK1 to 9). Structure and phylogeny analyses of these CDPK and CRK genes demonstrate evolutionary conservation in these gene families across H. brasiliensis and other plant species. The expression of HbCPK and HbCRK genes was investigated via Solexa sequencing in a range of experimental conditions (different tissues, phases of leaf development, ethylene treatment, and various abiotic stresses). The results suggest that HbCPK and HbCRK genes are important components in growth, development, and stress responses of H. brasiliensis. Parallel studies on the CDPK and CRK gene families were also extended to five other plant species (Arabidopsis thaliana, Oryza sativa, Populus trichocarpa, Manihot esculenta, and Ricinus communis). The CDPK and CRK genes from different plant species that exhibit similar expression patterns tend to cluster together, suggesting a coevolution of gene structure and expression behavior in higher plants. The results serve as a foundation to further functional studies of these gene families in H. brasiliensis as well as in the whole plant kingdom.

• Publication year

  2016

• Venue

  FEBS Open Bio

• Publication date

  2016-12-12

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/2211-5463.12163PMID 28097084PMCID 5221434
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Know where your clients are: subcellular localization and targets of calcium-dependent protein kinases.

  2016cited by this paper
• The rubber tree genome reveals new insights into rubber production and species adaptation

  2016cited by this paper
• COLD1 confers chilling tolerance in rice.

  2015cited by this paper
• Genome-Wide Identification of Calcium Dependent Protein Kinase Gene Family in Plant Lineage Shows Presence of Novel D-x-D and D-E-L Motifs in EF-Hand Domain

  2015cited by this paper
• Systemic cytosolic Ca(2+) elevation is activated upon wounding and herbivory in Arabidopsis.

  2015cited by this paper
• A rice calcium-dependent protein kinase OsCPK9 positively regulates drought stress tolerance and spikelet fertility

  2014cited by this paper
• Cassava genome from a wild ancestor to cultivated varieties

  2014cited by this paper
• Structure and expression profile of the sucrose synthase gene family in the rubber tree: indicative of roles in stress response and sucrose utilization in the laticifers

  2014cited by this paper
• Identification, expression and interaction analyses of calcium-dependent protein kinase (CPK) genes in canola (Brassica napus L.)

  2014cited by this paper
• CDPKs in immune and stress signaling.

  2013cited by this paper
• Calcium-Dependent Protein Kinases: Hubs in Plant Stress Signaling and Development1

  2013cited by this paper
• Genome-wide identification and expression analysis of calcium-dependent protein kinase in maize

  2013cited by this paper
• Plant Salt Tolerance

  2012cited by this paper
• Genome-wide identification, classification, and expression analysis of CDPK and its closely related gene families in poplar (Populus trichocarpa)

  2012cited by this paper
• Screening of valid reference genes for real-time RT-PCR data normalization in Hevea brasiliensis and expression validation of a sucrose transporter gene HbSUT3.

  2011cited by this paper
• The Arabidopsis Ca(2+) -dependent protein kinase CPK12 negatively regulates abscisic acid signaling in seed germination and post-germination growth.

  2011cited by this paper
• Molecular Characterization of HbCDPK1, an Ethephon-Induced Calcium-Dependent Protein Kinase Gene of Hevea brasiliensis

  2010cited by this paper
• AtCPK6, a functionally redundant and positive regulator involved in salt/drought stress tolerance in Arabidopsis

  2010cited by this paper
• The sucrose transporter HbSUT3 plays an active role in sucrose loading to laticifer and rubber productivity in exploited trees of Hevea brasiliensis (para rubber tree).

  2010cited by this paper
• Draft genome sequence of the ricin-producing oilseed castor bean

  2010cited by this paper
• Arabidopsis Calcium-Dependent Protein Kinase CPK10 Functions in Abscisic Acid- and Ca2+-Mediated Stomatal Regulation in Response to Drought Stress1[W][OA]

  2010cited by this paper
• Functional characterisation of OsCPK21, a calcium-dependent protein kinase that confers salt tolerance in rice

  2010cited by this paper
• The CBL-CIPK network in plant calcium signaling.

  2009cited by this paper
• Two Calcium-Dependent Protein Kinases, CPK4 and CPK11, Regulate Abscisic Acid Signal Transduction in Arabidopsis[W]

  2007cited by this paper
• Expression analysis of calcium-dependent protein kinase gene family during reproductive development and abiotic stress conditions in rice (Oryza sativa L. ssp. indica)

  2007cited by this paper
• Structure and functions of plant calcium-dependent protein kinases.

  2007cited by this paper
• Calcium Signaling Network in Plants

  2007cited by this paper
• The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray)

  2006cited by this paper
• Handling calcium signaling: Arabidopsis CaMs and CMLs.

  2005cited by this paper
• Is genome size influenced by colonization of new environments in dipteran species?

  2005cited by this paper
• Genome-wide identification of the rice calcium-dependent protein kinase and its closely related kinase gene families: comprehensive analysis of the CDPKs gene family in rice.

  2005cited by this paper
• Ethylene-mediated cross-talk between calcium-dependent protein kinase and MAPK signaling controls stress responses in plants.

  2005cited by this paper
• CDPK-mediated signalling pathways: specificity and cross-talk.

  2004cited by this paper
• Decoding Ca(2+) signals through plant protein kinases.

  2004cited by this paper
• OsCDPK13, a calcium-dependent protein kinase gene from rice, is induced by cold and gibberellin in rice leaf sheath

  2004cited by this paper
• The Arabidopsis CDPK-SnRK Superfamily of Protein Kinases

  2003cited by this paper
• CDPK-mediated signalling pathways: specificity and cross-talk.

  2003cited by this paper
• A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japonica)

  2002cited by this paper
• Calcium Signaling through Protein Kinases. The Arabidopsis Calcium-Dependent Protein Kinase Gene Family1

  2002cited by this paper
• A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica)

  2002cited by this paper
• Cell Signaling during Cold, Drought, and Salt Stress Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000596.

  2002cited by this paper
• A draft sequence of the rice genome (Oryza sativa L. ssp. japonica).

  2002cited by this paper
• Salt and drought stress signal transduction in plants.

  2002cited by this paper
• Calcium oscillations in higher plants.

  2001cited by this paper
• Calcium‐dependent protein kinases play an essential role in a plant defence response

  2001cited by this paper
• Plant salt tolerance.

  2001cited by this paper
• CDPKs - a kinase for every Ca2+ signal?

  2000cited by this paper
• The evolutionary fate and consequences of duplicate genes.

  2000cited by this paper
• A green chapter in the book of life

  2000cited by this paper
• Over-expression of a single Ca2+-dependent protein kinase confers both cold and salt/drought tolerance on rice plants.

  2000cited by this paper
• Laticifer Differentiation in Hevea brasiliensis : Induction by Exogenous Jasmonic Acid and Linolenic Acid

  2000cited by this paper
• Calcium-mediated signaling during sandalwood somatic embryogenesis. Role for exogenous calcium as second messenger.

  2000cited by this paper
• A 67-kDa plasma-membrane-bound Ca2+-stimulated protein kinase active in sink tissue of higher plants

  1998cited by this paper
• The regulation of cis-polyisoprene production (natural rubber) from Hevea brasiliensis

  1997cited by this paper
• A calcium-dependent protein kinase with a regulatory domain similar to calmodulin.

  1991cited by this paper

• Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.

  2026cites this paper
• Calcium-dependent protein kinases as central hubs in plant abiotic stress signaling: mechanisms and prospects for crop improvement

  2026cites this paper
• Genomic survey and expression analysis of the CDPK genes in Liriodendron Chinense to explore their potential functions under multiple abiotic stresses

  2026cites this paper
• Inter-Organellar Ca2+ Homeostasis in Plant and Animal Systems

  2025cites this paper
• Proteomics Analysis of C-Serum and Rubber Particles from Hevea brasiliensis (Clone RRIT 251)

  2025cites this paper
• Functional analysis of the PcCDPK5 gene in response to allelopathic substances on p-hydroxybenzoic acid (p-HBA) stress in patchouli.

  2025cites this paper
• Identification of a potential homeodomain-like gene governing leaf size and venation architecture in birch

  2025cites this paper
• Arabidopsis Calcium Dependent Protein Kinase 3, and Its Orthologues OsCPK1, OsCPK15, and AcCPK16, Are Involved in Biotic and Abiotic Stresses

  2025cites this paper
• Morphoanatomy and differential expression of genes latex synthesis and formation of laticiferous vessels in vitro seedlings of Hevea spp.

  2025cites this paper
• A plasma membrane Ca2+-dependent protein kinase PtCDPK2 promotes phosphorus starvation resilience in Phaeodactylum tricornutum

  2025cites this paper
• A quick guide to the calcium-dependent protein kinase family in Brassica napus.

  2024cites this paper
• Genomic survey and evolution analysis of calcium-dependent protein kinases in plants and their stress-responsive patterns in populus

  2024cites this paper
• TaCDPK1-5A positively regulates drought response through modulating osmotic stress responsive-associated processes in wheat (Triticum aestivum)

  2024cites this paper
• Genome-wide analysis of the CDPK gene family and their important roles response to cold stress in white clover

  2023cites this paper
• Differentially Expressed Genes in Jojoba (Simmondsia chinensis) when Subjected to Water-Stress

  2023cites this paper
• Calcium: A master regulator of stress tolerance in plants

  2023cites this paper
• The rubber tree kinome: Genome-wide characterization and insights into coexpression patterns associated with abiotic stress responses

  2023cites this paper
• Transcription level differences in Taxus wallichiana var. mairei elicited by Ce3+, Ce4+ and methyl jasmonate

  2022cites this paper
• The Calcium Sensor Calcineurin B-Like Proteins -Calcineurin B-Like Interacting Protein Kinases Is Involved in Leaf Development and Stress Responses Related to Latex Flow in Hevea brasiliensis

  2022cites this paper
• Molecular Characterization Reveals the Involvement of Calcium Dependent Protein Kinases in Abiotic Stress Signaling and Development in Chickpea (Cicer arietinum)

  2022cites this paper
• Calcium Signaling in Coordinating Plant Development, Circadian Oscillations and Environmental Stress Responses In Plants

  2022cites this paper
• EF-hand domain-containing proteins in Triticum aestivum: Insight into their roles in stress response and signalling

  2022cites this paper
• Insight into Genetic Mechanism and CDPK-Based Signalling Network Underlying Balanced Source to Sink Carbon Transfer in Wheat Under Multiple Stresses

  2022cites this paper
• Plant protein-coding gene families: Their origin and evolution

  2022cites this paper
• The role of CDPKs in plant development, nutrient and stress signaling

  2022cites this paper
• Functional Characterization of the Cystine-Rich-Receptor-like Kinases (CRKs) and Their Expression Response to Sclerotinia sclerotiorum and Abiotic Stresses in Brassica napus

  2022cites this paper
• Identification and expression assay of calcium-dependent protein kinase family genes in Hevea brasiliensis and determination of HbCDPK5 functions in disease resistance.

  2021cites this paper
• Cold stress‐induced miRNA and degradome changes in four soybean varieties differing in chilling resistance

  2021cites this paper
• Molecular Evolution of Calcium Signaling and Transport in Plant Adaptation to Abiotic Stress

  2021cites this paper
• Calcium Dependent Protein Kinases in Plants

  2020cites this paper
• Differential expression of calcium-dependent protein kinase genes (CDPK1–14) in Rubia cordifolia callus cultures transformed with the rolB and rolC genes

  2020cites this paper
• Genome-wide identification and expression analysis of the phosphatase 2A family in rubber tree (Hevea brasiliensis)

  2020cites this paper
• The Reyan 7-33-97 Rubber Tree Genome: Insight into Its Structure, Composition and Application

  2020cites this paper
• High-density SNP map facilitates fine mapping of QTLs and candidate genes discovery for Aspergillus flavus resistance in peanut (Arachis hypogaea)

  2020cites this paper
• Evolutionary Analysis of Calcium-Dependent Protein Kinase in Five Asteraceae Species

  2019cites this paper
• Differential expressions of citrus CAMTAs during fruit development and responses to abiotic stresses

  2019cites this paper
• Calcium-Dependent Protein Kinase Genes in Glycyrrhiza Uralensis Appear to be Involved in Promoting the Biosynthesis of Glycyrrhizic Acid and Flavonoids under Salt Stress

  2019influential citation
• Tipburn in lettuce (Lactuca Sativa L. ´Frillice´) : identifying climate factors that induce tipburn and cultivation methods that mitigate tipburn in controlled environment

  2019cites this paper
• Insights on Calcium-Dependent Protein Kinases (CPKs) Signaling for Abiotic Stress Tolerance in Plants

  2019cites this paper
• Calcium-mediation of jasmonate biosynthesis and signaling in plants.

  2019cites this paper
• HeveaDB: a genetic resource database for rubber tree genomic study

  2019cites this paper
• Functional Analysis of the Arabidopsis thaliana CDPK-Related Kinase Family: AtCRK1 Regulates Responses to Continuous Light

  2018cites this paper
• Calcium-Dependent Protein Kinase Family Genes Involved in Ethylene-Induced Natural Rubber Production in Different Hevea brasiliensis Cultivars

  2018cites this paper
• Genome-Wide Identification and Functional Analyses of the CRK Gene Family in Cotton Reveals GbCRK18 Confers Verticillium Wilt Resistance in Gossypium barbadense

  2018cites this paper
• Calcium Dependent Protein Kinase, a Versatile Player in Plant Stress Management and Development

  2017influential citation
• The SWEET gene family in Hevea brasiliensis – its evolution and expression compared with four other plant species

  2017cites this paper
• Metabolic and Hormonal Responses of Plants to Cold Stress

  2017cites this paper
• Identifikasi famili gen putatif penyandi protease inhibitor dengan pendekatan in silico komparatif pada genom Hevea brasiliensis Muell. Arg (Identification of putative gene family encoding protease inhibitors by in silico comparative analysis in Hevea brasiliensis Muell. Arg genome)

  2017cites this paper