THE PROTEIN COATS OR "GHOSTS" OF COLI PHAGE T2

Phage coats or ghosts, composed entirely of protein, appear to be responsible for protecting the phage nucleic acid from degradation by factors in the surrounding medium; attachment of the virus to its susceptible host; and delivering the nucleic acid to the interior of the cell. In addition, the ghosts have a number of biological actions which resemble similar actions of the parent phage. Thus, they both "kill" cells, inhibit pentosenucleic acid formation, interfere with subsequent infection by other virus particles, block adaptive enzyme formation, induce or trigger lysis of the host, and cause a leakage of phosphorus-containing fragments from the cell. Results to date fail to demonstrate a direct involvement of the ghosts in the passage of genetic information to the progeny. Several of the above changes induced in the host cell following attachment of ghosts could be derived from an alteration in but a single metabolic reaction. The stoichiometry of the ghost-bacterial cell interaction is different from that of the parent phage. Experiments to distinguish between a variable response of the host cell to reaction at different sites and a state of heterogeneity in the ghost preparations suggest the former but they are not decisive.

• Publication year

  1957

• Venue

  The Journal of General Physiology

• Publication date

  1957-11-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1085/JGP.41.2.307PMID 13475694PMCID 2194826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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