Glioblastoma vasculogenic mimicry: signaling pathways progression and potential anti-angiogenesis targets

Glioblastoma (GBM) is a highly angiogenic malignancy that is resistant to standard therapy; neo-formed vessels of this aggressive malignancy are thought to arise by sprouting of pre-existing brain capillaries. However, the conventional anti-angiogenic therapy, which seemed promising initially, shows transitory and incomplete efficacy. The discovery of vasculogenic mimicry (VM) has offered a new horizon for understanding tumor vascularization. VM is a tumor cell-constituted, matrix-embedded fluid-conducting meshwork that is independent of endothelial cells and is positively correlated with poor prognosis. Therefore, a better understanding of GBM vasculature is needed to optimize anti-angiogenic therapy. This review focuses on the signaling molecules and cascades involved in VM in relation to ongoing glioma research, as well as the clinical translational advances in GBM that have been offered by the development of optimized anti-angiogenesis treatment modalities.

• Publication year

  2015

• Venue

  Biomarker Research

• Publication date

  2015-04-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s40364-015-0034-3PMID 26085929PMCID 4469398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vasculogenic mimicry: a novel target for glioma therapy

  2014cited by this paper
• Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

  2014cited by this paper
• TGF-β promotes glioma cell growth via activating Nodal expression through Smad and ERK1/2 pathways.

  2014influential reference
• Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

  2014influential reference
• Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma.

  2014cited by this paper
• Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding

  2013cited by this paper
• Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma

  2013cited by this paper
• A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review)

  2013cited by this paper
• Targeting drug delivery systems for circumventing multidrug resistance of cancers.

  2013cited by this paper
• Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme

  2013influential reference
• CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia.

  2013cited by this paper
• Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: a systemic review and meta-analysis.

  2013cited by this paper
• MicroRNA-9 inhibits vasculogenic mimicry of glioma cell lines by suppressing Stathmin expression

  2013cited by this paper
• Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells

  2013influential reference
• Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

  2012cited by this paper
• Molecular Pathways Molecular Pathways : Vasculogenic Mimicry in Tumor Cells : Diagnostic and Therapeutic Implications

  2012cited by this paper
• Vasculogenic mimicry–potential target for glioblastoma therapy: an in vitro and in vivo study

  2012cited by this paper
• Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2

  2012cited by this paper
• Glioblastoma-derived Tumor Cells Induce Vasculogenic Mimicry through Flk-1 Protein Activation*

  2012influential reference
• Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol

  2012cited by this paper
• Transdifferentiation of Glioblastoma Stem-Like Cells into Mural Cells Drives Vasculogenic Mimicry in Glioblastomas

  2012influential reference
• Aberrant Signaling Pathways in Glioma

  2011influential reference
• Immunohistochemical expression of proinflammatory cytokines IL-1β, IL-6, TNF-α and involvement of COX-2, quantitatively confirmed by Western blot analysis, in Wernicke's encephalopathy.

  2011cited by this paper
• Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

  2011cited by this paper
• Transforming growth factor-β is required for vasculogenic mimicry formation in glioma cell line U251MG

  2011influential reference
• Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2

  2011cited by this paper
• Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

  2011cited by this paper
• A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.

  2010cited by this paper
• Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapy.

  2010cited by this paper
• Glioma stem cells involved in tumor tissue remodeling in a xenograft model.

  2010cited by this paper
• Antiangiogenesis therapy might have the unintended effect of promoting tumor metastasis by increasing an alternative circulatory system.

  2010cited by this paper
• Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.

  2010cited by this paper
• Signalling pathways in vasculogenic mimicry.

  2010cited by this paper
• [Inhibitory effect of lidamycin upon vasculogenic mimicry and its induction of apoptosis in glioma cells].

  2009cited by this paper
• Prognostic significance of periodic acid-Schiff-positive patterns in clear cell renal cell carcinoma.

  2009cited by this paper
• Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase.

  2009cited by this paper
• Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression.

  2009cited by this paper
• Modes of resistance to anti-angiogenic therapy

  2008cited by this paper
• Demonstrating circulation in vasculogenic mimicry patterns of uveal melanoma by confocal indocyanine green angiography

  2008cited by this paper
• Study on vasculogenic mimicry in malignant esophageal stromal tumors.

  2008cited by this paper
• Transforming growth factor‐β in cutaneous melanoma

  2008cited by this paper
• Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma

  2007cited by this paper
• TGF-β-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells

  2007cited by this paper
• Cancer stem cells and human malignant melanoma

  2007influential reference
• A pilot study of vasculogenic mimicry immunohistochemical expression in hepatocellular carcinoma.

  2007cited by this paper
• Genetic pathways to primary and secondary glioblastoma.

  2007influential reference
• [Vasculogenic mimicry in human primary gallbladder carcinoma and clinical significance thereof].

  2007cited by this paper
• TGF-beta-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells.

  2007cited by this paper
• Microcirculation patterns in different stages of melanoma growth.

  2006cited by this paper
• Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness

  2006cited by this paper
• VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: Implications for vasculogenic mimicry

  2006influential reference
• EphA2 as a Novel Molecular Marker and Target in Glioblastoma Multiforme

  2005cited by this paper
• Does Vasculogenic Mimicry Exist in Astrocytoma?

  2005cited by this paper
• Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

  2004influential reference
• EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation

  2004influential reference
• Vasculogenic mimicry

  2004cited by this paper
• Erratum: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma (Cancer Research (October 2004) 64 (7011-7021)

  2004cited by this paper
• Angiogenesis: Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma

  2003cited by this paper
• Targeting the Tumor Microenvironment with Chemically Modified Tetracyclines: Inhibition of Laminin 5 γ2 Chain Promigratory Fragments and Vasculogenic Mimicry1Supported by NIH/National Cancer Institute Grants CA83137 (to R. E. B. S.), CA80318, CA88043-02S1, and CA59702 (to M. J. C. H.).1

  2002cited by this paper
• Vasculogenic mimicry and pseudo‐comedo formation in breast cancer

  2002cited by this paper
• Targeting the tumor microenvironment with chemically modified tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry.

  2002cited by this paper
• The Clinical Significance of Tumor Cell-Lined Vasculature in Ovarian Carcinoma: Implications for Anti-Vasculogenic Therapy

  2002cited by this paper
• Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma.

  2001cited by this paper
• Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry

  2001cited by this paper
• Vasculogenic mimicry in tumors. Fact or artifact?

  2000cited by this paper
• Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.

  1999cited by this paper
• Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow

  1998cited by this paper
• LABORATORY INVESTIGATION- HUMAN/ANIMAL TISSUE Clinical significance of vasculogenic mimicry in human gliomas

  year unknowninfluential reference
• Cdh5 Is Specifically Activated in Glioblastoma Stemlike Cells and Contributes to Vasculogenic Mimicry Induced by Hypoxia Neuro-onco Lo Gy Materials and Methods

  year unknowninfluential reference

• Glioblastoma cell plasticity: A new paradigm in glioblastoma therapeutic resistance.

  2026cites this paper
• Establishment of Vasculogenic Mimicry-Correlated Model to Predict Prognosis and Therapeutic Efficacy in Patients With Glioblastoma.

  2026cites this paper
• The Roles of RNA-Binding Proteins in Vasculogenic Mimicry Regulation in Glioblastoma

  2025cites this paper
• A SORT1/EGFR molecular interplay as a prognostic biomarker in glioblastoma vasculogenic mimicry: implications in the transcriptional regulation of cancer stemness and drug resistance

  2025cites this paper
• Transcriptomic-Driven Drug Repurposing Reveals SP600125 as a Promising Drug Candidate for the Treatment of Glial-Mesenchymal Transition in Glioblastoma

  2025cites this paper
• Advancing glioblastoma therapy with surface-modified nanoparticles

  2025cites this paper
• Specifics of VEGF-A, VEGF-C and their receptors levels in the tumor and blood of patients with endometrial cancer depending on the histological type

  2025cites this paper
• Interplay between cytokine and FGF2 signaling in induction of entosis and vasculogenic mimicry response in glioblastoma

  2025cites this paper
• Microvascular density and vasculogenic mimicry the predictive signatures of prognosis and therapeutic response in gliomas—a systematic review and meta-analysis protocol

  2024cites this paper
• A Role for the Hippo/YAP1 Pathway in the Regulation of In Vitro Vasculogenic Mimicry in Glioblastoma Cells

  2024cites this paper
• The challenges and clinical landscape of glioblastoma immunotherapy

  2024cites this paper
• Targeted Delivery of Nanomedicines to Glioblastoma: Overcoming the Clinical Barrier

  2024cites this paper
• Transcriptional regulation of CYR61 and CTGF by LM98: a synthetic YAP-TEAD inhibitor that targets in-vitro vasculogenic mimicry in glioblastoma cells

  2024cites this paper
• HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells

  2024cites this paper
• Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice

  2024cites this paper
• Investigating Trans-differentiation of Glioblastoma Cells in an In Vitro 3D Model of the Perivascular Niche.

  2023cites this paper
• Shaping the brain vasculature in development and disease in the single-cell era

  2023cites this paper
• Platelet-derived growth factor signalling in neurovascular function and disease.

  2022cites this paper
• Differential P-Glycoprotein/CD31 Expression as Markers of Vascular Co-Option in Primary Central Nervous System Tumors

  2022cites this paper
• MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1

  2022cites this paper
• Tailoring biomaterials and applications targeting tumor-associated macrophages in cancers

  2022cites this paper
• Glioblastoma-Specific Strategies of Vascularization: Implications in Anti-Angiogenic Therapy Resistance

  2022cites this paper
• Multiple Faces of the Glioblastoma Microenvironment

  2022cites this paper
• Regulatory mechanisms and therapeutic targeting of vasculogenic mimicry in hepatocellular carcinoma.

  2021cites this paper
• Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer.

  2021cites this paper
• N6-Isopentenyladenosine Hinders the Vasculogenic Mimicry in Human Glioblastoma Cells through Src-120 Catenin Pathway Modulation and RhoA Activity Inhibition

  2021cites this paper
• Contribution of Adventitia-Derived Stem and Progenitor Cells to New Vessel Formation in Tumors

  2021cites this paper
• Correlation between the characteristics of ultrasonic contrast and the regional distribution of tumor vascular heterogeneity in breast cancer

  2021cites this paper
• Tumor Vessels Fuel the Fire in Glioblastoma

  2021cites this paper
• Discovery of peculiar cells in the peri-tumoral regions and peripheral blood of glioblastoma patients by single cell RNA-sequencing

  2020cites this paper
• Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies.

  2020cites this paper
• Albumin-stabilized manganese-based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors.

  2020cites this paper
• Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.

  2020cites this paper
• Exploring Novel Molecular Targets for the Treatment of High-Grade Astrocytomas Using Peptide Therapeutics: An Overview

  2020cites this paper
• Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

  2020cites this paper
• Environmental Interplay: Stromal Cells and Biomaterial Composition Influence in the Glioblastoma Microenvironment.

  2020cites this paper
• Genetic characterization of stem cell-like cancer cell in the peri-tumoral regions and proliferative lymphocyte in the peripheral blood of patients with glioblastoma

  2020cites this paper
• Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway

  2020cites this paper
• Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure

  2019cites this paper
• The Role of Brain Vasculature in Glioblastoma

  2019cites this paper
• Correlation of Preoperative Von Willebrand Factor with Magnetic Resonance Imaging Perfusion and Permeability Parameters as Predictors of Prognosis in Glioblastoma.

  2019cites this paper
• Molecular mechanisms involved in angiogenesis and potential target of antiangiogenesis in human glioblastomas

  2018cites this paper
• CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

  2018cites this paper
• RETRACTED ARTICLE: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

  2018cites this paper
• Triptonide potently suppresses pancreatic cancer cell‐mediated vasculogenic mimicry by inhibiting expression of VE‐cadherin and chemokine ligand 2 genes

  2018cites this paper
• BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma

  2018cites this paper
• Therapeutic approach in glioblastoma multiforme with primitive neuroectodermal tumor components: Case report and review of the literature.

  2018cites this paper
• Roles of EphA2 Receptor in Angiogenesis Signaling Pathway of Glioblastoma Multiforme

  2018cites this paper
• Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma

  2017cites this paper
• Next-Generation Sequencing in Glioblastoma Personalized Therapy

  2017cites this paper
• Overexpression of leptin receptor in human glioblastoma: Correlation with vasculogenic mimicry and poor prognosis

  2017cites this paper
• Angiogenesis inhibitors in tackling recurrent glioblastoma

  2017cites this paper
• MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation.

  2017cites this paper
• Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles.

  2017cites this paper
• Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy

  2017cites this paper
• Advances in Biology and Treatment of Glioblastoma

  2017cites this paper
• Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma

  2017cites this paper
• Glioblastoma Multiforme Cancer Stem Cells Express Components of the Renin–Angiotensin System

  2016cites this paper
• MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration.

  2016cites this paper
• Vasculogenic mimicry in malignant mesothelioma: an experimental and immunohistochemical analysis.

  2016cites this paper
• The Translational Significance of the Neurovascular Unit*

  2016cites this paper
• Dual Parallel Sequence Progression as Vascular Pseudo-Reactivities to Tumor Necrosis and to Proliferation of Glioblastoma Cells

  2016cites this paper
• Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7.

  2016cites this paper
• Glioma Stem Cells: Signaling, Microenvironment, and Therapy

  2016cites this paper
• Vascular Mimicry: The Next Big Glioblastoma Target

  2015cites this paper
• Double Immunohistochemical Staining on Formalin-Fixed Paraffin-Embedded Tissue Samples to Study Vascular Co-option.

  year unknowncites this paper