Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00039.2012PMID 23151801PMCID PMC3566440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways.

  2012cited by this paper
• miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling.

  2012cited by this paper
• Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.

  2011cited by this paper
• Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents.

  2010cited by this paper
• Regulation of the Human Cardiac Mitochondrial Ca2+ Uptake by 2 Different Voltage-Gated Ca2+ Channels

  2009cited by this paper
• Mitochondrial Ca2+ as a key regulator of cell life and death

  2007cited by this paper
• Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.

  2007cited by this paper
• Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

  2006cited by this paper
• Microdomains of Intracellular Ca : Molecular Determinants and Functional Consequences

  2005cited by this paper
• The mitochondrial calcium uniporter is a highly selective ion channel

  2004cited by this paper
• In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy.

  2004cited by this paper
• Effects of Adenovirus‐Mediated Sorcin Overexpression on Excitation‐Contraction Coupling in Isolated Rabbit Cardiomyocytes

  2003cited by this paper
• Sorcin Regulates Excitation-Contraction Coupling in the Heart*

  2003cited by this paper
• Sorcin Inhibits Calcium Release and Modulates Excitation-Contraction Coupling in the Heart*

  2003cited by this paper
• Extracellular S100A1 Protein Inhibits Apoptosis in Ventricular Cardiomyocytes via Activation of the Extracellular Signal-regulated Protein Kinase 1/2 (ERK1/2)*

  2003cited by this paper
• Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae.

  2002cited by this paper
• Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway.

  2002cited by this paper
• Identification of a Ryanodine Receptor in Rat Heart Mitochondria*

  2001cited by this paper
• Reducing the Environmental Sensitivity of Yellow Fluorescent Protein

  2001cited by this paper
• Circularly permuted green fluorescent proteins engineered to sense Ca2+

  2001cited by this paper
• Beat‐to‐beat oscillations of mitochondrial [Ca2+] in cardiac cells

  2001cited by this paper
• Transport of Ca2+ from Sarcoplasmic Reticulum to Mitochondria in Rat Ventricular Myocytes

  2000cited by this paper
• Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractility.

  1999cited by this paper
• Role of mitochondrial calcium transport in the control of substrate oxidation

  1998cited by this paper
• A growing family of the Ca2+-binding proteins with five EF-hand motifs.

  1997cited by this paper
• Calcium‐ and pH‐linked oligomerization of sorcin causing translocation from cytosol to membranes

  1997cited by this paper
• Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate‐putamen nucleus: Association with ryanodine receptors and intracellular calcium release

  1997cited by this paper
• Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake.

  1996cited by this paper
• Association of Sorcin With the Cardiac Ryanodine Receptor (*)

  1995cited by this paper
• Calcium‐dependent translocation of sorcin to membranes: functional relevance in contractile tissue

  1995cited by this paper
• Mitochondrial calcium transport: physiological and pathological relevance.

  1994cited by this paper
• Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria.

  1993cited by this paper
• Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes.

  1991cited by this paper
• Mechanisms by which mitochondria transport calcium.

  1990cited by this paper
• A 22‐kd protein (sorcin/V19) encoded by an amplified gene in multidrug‐resistant cells, is homologous to the calcium‐binding light chain of calpain.

  1986cited by this paper
• Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells

  1985cited by this paper
• Increased synthesis of a low molecular weight protein in vincristine-resistant cells.

  1981cited by this paper

• Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

  2025cites this paper
• Sorcin in Cancer Development and Chemotherapeutic Drug Resistance

  2024cites this paper
• Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

  2023cites this paper
• Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways

  2023cites this paper
• TRAP1 Chaperones the Metabolic Switch in Cancer

  2022cites this paper
• AnnexinA7 promotes epithelial–mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma

  2021cites this paper
• A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer

  2021cites this paper
• Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer’s Disease on the Pump Activity

  2021cites this paper
• Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance

  2021cites this paper
• Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

  2020cites this paper
• Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases

  2020cites this paper
• Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

  2018cites this paper
• Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function

  2018cites this paper
• Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes.

  2018cites this paper
• Free fatty acids and insulin hypersecretion studied in human islets

  2018cites this paper
• Targeting P‐glycoprotein and SORCIN: Dihydromyricetin strengthens anti‐proliferative efficiency of adriamycin via MAPK/ERK and Ca2+‐mediated apoptosis pathways in MCF‐7/ADR and K562/ADR

  2018cites this paper
• The Role of Sorcin in Excitation-Contraction Coupling in Normal and Diseased Hearts

  2017cites this paper
• Expression of the mitochondrial calcium uniporter in cardiac myocytes improves impaired mitochondrial calcium handling and metabolism in simulated hyperglycemia.

  2016cites this paper
• Overexpression of SORCIN is a Prognostic Biomarker for Multidrug-Resistant Pediatric Acute Lymphoblastic Leukemia and Correlates with Upregulated MDR1/P-gp

  2016cites this paper
• Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: A novel strategy for human BRAF-driven colorectal carcinoma

  2015cites this paper
• Tumor and Stem Cell Biology TRAP 1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression : A Novel Target for BRAF-Mutated Colorectal Tumors

  2014cites this paper
• Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells

  2014cites this paper
• Regulation of SERCA pumps expression in diabetes.

  2014cites this paper
• TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.

  2014cites this paper
• Sorcin Links Calcium Signaling to Vesicle Trafficking, Regulates Polo-Like Kinase 1 and Is Necessary for Mitosis

  2014cites this paper
• Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1

  2013cites this paper