Identification and Characterization of a Novel Class of Atypical Dopamine Receptor Agonists

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Pharmaceutical Research

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11095-012-0754-0PMID 22547031
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies.

  2011cited by this paper
• Histidine 6.55 Is a Major Determinant of Ligand-Biased Signaling in Dopamine D2L Receptor

  2011cited by this paper
• Structure and Function of an Irreversible Agonist-β2 Adrenoceptor complex

  2010cited by this paper
• Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

  2010cited by this paper
• Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

  2010influential reference
• The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

  2010cited by this paper
• Development of tolerance in D3 dopamine receptor signaling is accompanied by distinct changes in receptor conformation.

  2010cited by this paper
• Structure of a nanobody-stabilized active state of the β2 adrenoceptor

  2010cited by this paper
• Hybrid Scoring and Classification Approaches to Predict Human Pregnane X Receptor Activators

  2009cited by this paper
• Shape signatures: new descriptors for predicting cardiotoxicity in silico.

  2008cited by this paper
• New Predictive Models for Blood–Brain Barrier Permeability of Drug-like Molecules

  2008cited by this paper
• Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors

  2007cited by this paper
• Functional Selectivity and Classical Concepts of Quantitative Pharmacology

  2007cited by this paper
• High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

  2007cited by this paper
• GPCR functional selectivity has therapeutic impact.

  2007cited by this paper
• The tolerance property of human D3 dopamine receptor is determined by specific amino acid residues in the second cytoplasmic loop.

  2007cited by this paper
• The novel antidyskinetic drug sarizotan elicits different functional responses at human D2-like dopamine receptors.

  2006cited by this paper
• Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters

  2006cited by this paper
• Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.

  2005cited by this paper
• Signaling Mechanisms of the D3 Dopamine Receptor

  2004cited by this paper
• The effects of dopamine D3 agonists and antagonists in a nonhuman primate model of tardive dyskinesia.

  2004cited by this paper
• Identification and characterization of novel properties of the human D3 dopamine receptor

  2004cited by this paper
• Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum.

  2004cited by this paper
• Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function

  2003cited by this paper
• Ligand-selective receptor conformations revisited: the promise and the problem.

  2003cited by this paper
• Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites

  2003cited by this paper
• Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.

  2002cited by this paper
• Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.

  2002cited by this paper
• BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

  2001cited by this paper
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

  2001cited by this paper
• Dominant-Negative Mutants Identify a Role for Girk Channels in D3 Dopamine Receptor-Mediated Regulation of Spontaneous Secretory Activity

  2000cited by this paper
• Human dopamine D(3) receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism.

  1999cited by this paper
• Activation of Human D3 Dopamine Receptor Inhibits P/Q-Type Calcium Channels and Secretory Activity in AtT-20 Cells

  1999cited by this paper
• Prominence of the dopamine D2 short isoform in dopaminergic pathways.

  1998cited by this paper
• Behavioral and neurochemical effects of the preferential dopamine D3 receptor agonist cis-8-OH-PBZI.

  1998cited by this paper
• Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines.

  1998cited by this paper
• Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes

  1997cited by this paper
• Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor.

  1997cited by this paper
• Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.

  1997cited by this paper
• The preferential dopamine D3 receptor agonist cis-8-OH-PBZI induces limbic Fos expression in rat brain.

  1997cited by this paper
• D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels in Xenopus oocytes.

  1996cited by this paper
• Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

  1996cited by this paper
• G protein-coupled inward rectifier modulated by dopamine agonists in cultured substantia nigra neurons.

  1995cited by this paper
• Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation.

  1995influential reference
• Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

  1995cited by this paper
• Functional expression of human D3 dopamine receptors in differentiated neuroblastoma × glioma NG108–15 cells

  1994cited by this paper
• Comparative protein modelling by satisfaction of spatial restraints.

  1993cited by this paper

• A nanoluciferase complementation-based assay for monitoring β-arrestin2 recruitment to the dopamine D3 receptor

  2025cites this paper
• Substance Addiction Rehabilitation Drugs

  2024cites this paper
• G-protein Biased Signaling Agonists of Dopamine D3 Receptor Promote Distinct Activation Patterns of ERK1/2.

  2022cites this paper
• Dopamine D3 receptor ligands: a patent review (2014–2020)

  2022cites this paper
• Dopamine agonists in treatment of Parkinson's disease: an overview

  2020cites this paper
• Biased signaling agonist of dopamine D3 receptor induces receptor internalization independent of &bgr;‐arrestin recruitment

  2019cites this paper
• Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.

  2017cites this paper
• In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease.

  2016cites this paper
• Designing modulators of monoamine transporters using virtual screening techniques

  2015cites this paper
• Identification of key residues involved in the activation and signaling properties of dopamine D3 receptor.

  2015cites this paper
• Characterization of D3 Dopamine Receptor Agonist-Dependent Tolerance Property

  2015cites this paper
• DRD1 and DRD4 dopamine receptors in the etiology of preeclampsia.

  2015cites this paper
• In vitro and in vivo characterization of the agonist-dependent D3 dopamine receptor tolerance property.

  2014cites this paper
• Overexpression of the dopamine D3 receptor in the rat dorsal striatum induces dyskinetic behaviors.

  2014cites this paper
• POLIMORFIZM KATECHOLO-O-METYLOTRANSFERAZY (COMT) ORAZ RECEPTORÓW DOPAMINY (DRD1, DRD4) W ETIOLOGII I TERAPII STANU PRZEDRZUCAWKOWEGO

  2014cites this paper
• Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action.

  2013cites this paper
• An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptor.

  2013cites this paper
• Homology Modeling of Dopamine D2 and D3 Receptors: Molecular Dynamics Refinement and Docking Evaluation

  2012cites this paper