Chronic ouabain treatment induces vasa recta endothelial dysfunction in the rat.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  AJP - Renal Physiology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/ajprenal.90429.2008PMID 18945826PMCID PMC2636913
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Membrane current oscillations in descending vasa recta pericytes.

  2008cited by this paper
• Identification of a Pool of Non-pumping Na/K-ATPase*

  2007cited by this paper
• Regulation of Cardiac Na+/Ca2+ Exchanger by Phospholemman

  2007cited by this paper
• Vasa recta voltage-gated Na+ channel Nav1.3 is regulated by calmodulin.

  2007cited by this paper
• H2O2 activation of HSP25/27 protects desmin from calpain proteolysis in rat ventricular myocytes.

  2007cited by this paper
• Ouabain modulation of cellular calcium stores and signaling.

  2007cited by this paper
• Salt intake and depletion increase circulating levels of endogenous ouabain in normal men.

  2006cited by this paper
• How does salt retention raise blood pressure?

  2006cited by this paper
• Ouabain modulation of endothelial calcium signaling in descending vasa recta.

  2006cited by this paper
• The central role of the brain in salt-sensitive hypertension

  2006cited by this paper
• An N-terminal Sequence Targets and Tethers Na+ Pump α2 Subunits to Specialized Plasma Membrane Microdomains*

  2006cited by this paper
• FXYD proteins: new regulators of Na-K-ATPase.

  2006cited by this paper
• The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.

  2005cited by this paper
• Sodium pump α2 subunits control myogenic tone and blood pressure in mice

  2005cited by this paper
• Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta.

  2005cited by this paper
• The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.

  2005cited by this paper
• Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex.

  2005cited by this paper
• Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats.

  2005cited by this paper
• Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

  2005cited by this paper
• Chronic ANG II infusion increases NO generation by rat descending vasa recta.

  2005cited by this paper
• Determinants of basal nitric oxide concentration in the renal medullary microcirculation.

  2004cited by this paper
• Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle

  2004cited by this paper
• Biosynthesis of endogenous cardiac glycosides by mammalian adrenocortical cells: three steps forward.

  2004cited by this paper
• Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function.

  2003cited by this paper
• Role of renal NO production in the regulation of medullary blood flow.

  2003cited by this paper
• Physiology of the renal medullary microcirculation.

  2003cited by this paper
• Inhibition of Apoptosis by Amphiregulin via an Insulin‐like Growth Factor‐1 Receptor—Dependent Pathway in Non‐Small Cell Lung Cancer Cell Lines

  2003cited by this paper
• Sex, digitalis, and the sodium pump.

  2003cited by this paper
• Functional roles of the alpha isoforms of the Na,K-ATPase.

  2003cited by this paper
• Functional Roles of the α Isoforms of the Na,K‐ATPase

  2003cited by this paper
• Glutamine delays spontaneous apoptosis in neutrophils.

  2003cited by this paper
• Salt, endogenous ouabain and blood pressure interactions in the general population

  2003cited by this paper
• Salt, endogenous ouabain and blood pressure interactions in the general population.

  2003cited by this paper
• Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors.

  2002cited by this paper
• Tubulovascular Nitric Oxide Crosstalk: Buffering of Angiotensin II–Induced Medullary Vasoconstriction

  2002cited by this paper
• Structural complexity and functional diversity of endoplasmic reticulum Ca(2+) stores.

  2001cited by this paper
• Nitric oxide generation by isolated descending vasa recta.

  2001cited by this paper
• Pericyte Regulation of Renal Medullary Blood Flow

  2001cited by this paper
• Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin.

  2000cited by this paper
• Increase in renal medullary nitric oxide synthase activity protects from norepinephrine-induced hypertension.

  2000cited by this paper
• Unloading and refilling of two classes of spatially resolved endoplasmic reticulum Ca2+ stores in astrocytes

  2000cited by this paper
• Nitric oxide in the renal medulla protects from vasopressin-induced hypertension.

  2000cited by this paper
• Na(+) entry via store-operated channels modulates Ca(2+) signaling in arterial myocytes.

  2000cited by this paper
• Ouabain augments Ca(2+) transients in arterial smooth muscle without raising cytosolic Na(+).

  2000cited by this paper
• The influence of nanomolar ouabain on vascular pressor responses is modulated by the endothelium.

  1999cited by this paper
• Sodium/calcium exchange: its physiological implications.

  1999cited by this paper
• Response of isolated rat descending vasa recta to bradykinin.

  1998cited by this paper
• Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function.

  1998cited by this paper
• Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla.

  1997cited by this paper
• Evidence for the presence of smooth muscle α-actin within pericytes of the renal medulla.

  1997cited by this paper
• Role of the renal medulla in volume and arterial pressure regulation.

  1997cited by this paper
• Endothelial modulation of ouabain-induced contraction and sodium pump activity in aortas of normotensive Wistar-Kyoto and spontaneously hypertensive rats.

  1996cited by this paper
• Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis.

  1996cited by this paper
• Chronic sodium-potassium-ATPase inhibition with ouabain impairs renal haemodynamics and pressure natriuresis in the rat.

  1996cited by this paper
• Effect of norepinephrine and acetylcholine on outer medullary descending vasa recta.

  1995cited by this paper
• Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.

  1995cited by this paper
• Ouabain‐induced hypertension in the rat: relationships among plasma and tissue ouabain and blood pressure

  1994cited by this paper
• Role of ouabain-like factors in hypertension : effects of ouabain and certain endogenous ouabain-like factors in hypertension

  1993cited by this paper
• Role of ouabain-like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hypertension.

  1993cited by this paper
• Identification and characterization of a ouabain-like compound from human plasma

  1991cited by this paper

• Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

  2025cites this paper
• NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function.

  2020cites this paper
• On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease

  2017cites this paper
• Long-Term Ouabain Treatment Impairs Vascular Function in Resistance Arteries

  2016cites this paper
• Na(+), K(+)-ATPase dysfunction causes cerebrovascular endothelial cell degeneration in rat prefrontal cortex slice cultures.

  2016cites this paper
• Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control

  2014cites this paper
• Natriuretic Hormones, Endogenous Ouabain, and Related Sodium Transport Inhibitors

  2014cites this paper
• Wistar Rats Resistant to the Hypertensive Effects of Ouabain Exhibit Enhanced Cardiac Vagal Activity and Elevated Plasma Levels of Calcitonin Gene-Related Peptide

  2014cites this paper
• Endocrine disruptors, gene deregulation and male germ cell tumors.

  2013cites this paper
• Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.

  2013cites this paper
• Renal medullary circulation.

  2012cites this paper
• How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.

  2012influential citation
• Salt sensitivity, endogenous ouabain and hypertension

  2012cites this paper
• PAPEL DA OUABAÍNA ENDÓGENA SOBRE O SISTEMA CARDIOVASCULAR DO MODELO DE HIPERTENSÃO ARTERIAL DOCA-SAL

  2012cites this paper
• Endogenous Ouabain: A Link Between Sodium Intake and Hypertension

  2011cites this paper
• Ion and Fluid Dynamics in Hypertension

  2011cites this paper
• Long-Term Ouabain Treatment Impairs Vascular Function in Resistance Arteries

  2011cites this paper
• Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.

  2010cites this paper
• Intrinsic nitric oxide and superoxide production regulates descending vasa recta contraction.

  2010cites this paper
• Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries.

  2010cites this paper
• PAPEL DOS RINS NA HIPERTENSÃO ARTERIAL INDUZIDA PELO TRATAMENTO CRÔNICO COM OUABAÍNA EM RATOS

  2009cites this paper
• Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance.

  2009cites this paper