A novel role for WAVE1 in controlling actin network growth rate and architecture

A novel functional role for WAVE1 is found that is lacking in N-WASP and WAVE2. Through its unique WH2 domain, WAVE1 dramatically reduces the rate of actin filament elongation independently of its interactions with the Arp2/3 complex. These findings help explain how cells build actin networks with distinct geometries and growth rates.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E14-10-1477PMID 25473116PMCID 4310740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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