Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Endocrinology

• Publication date

  2015-08-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2015-1392PMID 26241069PMCID PMC4588833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Phosphorylation of epigenetic "readers, writers and erasers": Implications for developmental reprogramming and the epigenetic basis for health and disease.

  2015cited by this paper
• Estrogens in the wrong place at the wrong time: Fetal BPA exposure and mammary cancer.

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• Taxonomy of breast cancer based on normal cell phenotype predicts outcome.

  2014cited by this paper
• Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

  2014cited by this paper
• Is the differentiation into molecular subtypes of breast cancer important for staging, local and systemic therapy, and follow up?

  2014cited by this paper
• Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.

  2014cited by this paper
• Invasive Breast Carcinoma

  2014cited by this paper
• Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells

  2014cited by this paper
• [WHO classification of tumors of the breast].

  2014cited by this paper
• Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank

  2014cited by this paper
• Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

  2014cited by this paper
• Identification of multipotent mammary stem cells by protein C receptor expression

  2014cited by this paper
• R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal

  2014cited by this paper
• Progesterone stimulates progenitor cells in normal human breast and breast cancer cells

  2014cited by this paper
• The impact of vitamin D in breast cancer: genomics, pathways, metabolism

  2014cited by this paper
• Complexities of androgen receptor signalling in breast cancer.

  2014cited by this paper
• Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

  2013cited by this paper
• Comment on “Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast”

  2013cited by this paper
• Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

  2013cited by this paper
• Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort

  2013cited by this paper
• Invasive breast carcinoma: pathology and prognosis

  2013cited by this paper
• Progesterone receptors, their isoforms and progesterone regulated transcription.

  2012cited by this paper
• Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial.

  2012cited by this paper
• Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

  2012cited by this paper
• Perinatal exposure to bisphenol a increases adult mammary gland progesterone response and cell number.

  2011cited by this paper
• Distinct stem cells contribute to mammary gland development and maintenance

  2011cited by this paper
• Canine mammary tumours, an overview.

  2011cited by this paper
• Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway

  2011cited by this paper
• Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

  2011cited by this paper
• RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

  2010influential reference
• Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

  2010cited by this paper
• Hormone action in the mammary gland.

  2010cited by this paper
• American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version).

  2010cited by this paper
• Control of mammary stem cell function by steroid hormone signalling

  2010cited by this paper
• Wnt and mammary stem cells: hormones cannot fly wingless.

  2010cited by this paper
• Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

  2010cited by this paper
• Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.

  2010cited by this paper
• American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

  2010cited by this paper
• Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women.

  2010cited by this paper
• Progesterone induces adult mammary stem cell expansion

  2010cited by this paper
• Oral Exposure to Bisphenol A Increases Dimethylbenzanthracene-Induced Mammary Cancer in Rats

  2009cited by this paper
• β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells

  2008cited by this paper
• Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal women

  2007cited by this paper
• Exposure of the U.S. Population to Bisphenol A and 4-tertiary-Octylphenol: 2003–2004

  2007cited by this paper
• Stem Cells and the Stem Cell Niche in the Breast: An Integrated Hormonal and Developmental Perspective

  2007cited by this paper
• The decrease in breast-cancer incidence in 2003 in the United States.

  2007cited by this paper
• Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure.

  2007cited by this paper
• Cancer risk in women prenatally exposed to diethylstilbestrol

  2007cited by this paper
• Progesterone Receptors Upregulate Wnt-1 To Induce Epidermal Growth Factor Receptor Transactivation and c-Src-Dependent Sustained Activation of Erk1/2 Mitogen-Activated Protein Kinase in Breast Cancer Cells

  2006cited by this paper
• Generation of a functional mammary gland from a single stem cell

  2006cited by this paper
• SEER Cancer Statistics Review, 1975-2003

  2006cited by this paper
• Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland

  2006cited by this paper
• Purification and unique properties of mammary epithelial stem cells

  2006cited by this paper
• STEROIDRECEPTORSANDPROLIFERATIONIN THE HUMANBREAST Results and Discussion Distribution of ER in Normal Human Breast Lobules

  2006cited by this paper
• Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice.

  2005cited by this paper
• Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.

  2005cited by this paper
• Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.

  2004cited by this paper
• Breast cancer risk by age at birth, time since birth and time intervals between births: exploring interaction effects

  2004cited by this paper
• Risk factors for breast cancer according to estrogen and progesterone receptor status.

  2004cited by this paper
• Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

  2003cited by this paper
• Breast cancer and hormone-replacement therapy in the Million Women Study.

  2003cited by this paper
• Breast cancer and hormone-replacement therapy: the Million Women Study.

  2003cited by this paper
• Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

  2002cited by this paper
• Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

  2002cited by this paper
• Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells*

  2002cited by this paper
• Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.

  2002cited by this paper
• Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment.

  2000cited by this paper
• C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.

  2000cited by this paper
• Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling.

  2000cited by this paper
• C/EBPβ (CCAAT/Enhancer Binding Protein) Controls Cell Fate Determination during Mammary Gland Development

  2000cited by this paper
• Prolactin controls mammary gland development via direct and indirect mechanisms.

  1999cited by this paper
• The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women.

  1998cited by this paper
• Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats.

  1998cited by this paper
• A paracrine role for the epithelial progesterone receptor in mammary gland development.

  1998cited by this paper
• Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies

  1996cited by this paper
• Medroxyprogesterone acetate accelerates the development and increases the incidence of mouse mammary tumors induced by dimethylbenzanthracene.

  1996cited by this paper
• Refractoriness to mammary tumorigenesis in parous rats: is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia?

  1995cited by this paper
• Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.

  1988cited by this paper
• Direct action of 17 beta-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography.

  1987cited by this paper
• A Correlative Morphologic Study of Human Breast and Endometrium in the Menstrual Cycle

  1986cited by this paper
• ‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer

  1983cited by this paper
• Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

  1982cited by this paper
• Progesterone receptors in normal mammary gland: receptor modulations in relation to differentiation

  1980cited by this paper
• Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae.

  1979cited by this paper
• Progesterone receptors in normal mammary glands of mice: characterization and relationship to development.

  1979cited by this paper
• Cyclic Variation of DNA synthesis in human breast epithelium.

  1977cited by this paper
• Incidence of cancer in United States blacks.

  1975cited by this paper
• Serum androstenedione and testosterone levels during the menstrual cycle.

  1973cited by this paper
• Menopause and breast cancer risk.

  1972cited by this paper
• The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland.

  1971cited by this paper
• Age at first birth and breast cancer risk.

  1970cited by this paper
• On the Treatment of Inoperable Cases of Carcinoma of the Mamma: Suggestions for a New Method of Treatment, with Illustrative Cases

  1896influential reference

• Exploring the complex relationship between metabolomics and breast cancer early detection (Review)

  2025influential citation
• Epidemiological, Clinical, Radiological and Histopathological Aspects of Female Breast Cancer in the Gbêkê Region (Bouaké)

  2025cites this paper
• Manganese-induced Precocious Puberty Alters Mammary Epithelial Cell Proliferation in Female Rats

  2025cites this paper
• Hormone, Targeted, and Combinational Therapies for Breast Cancers: From Humans to Dogs

  2024cites this paper
• Exposure to air pollutants and breast cancer risk: mediating effects of metabolic health biomarkers in a nested case–control study within the E3N-Generations cohort

  2024cites this paper
• Promoting effect of Sunset Yellow on N-methyl N-nitrosourea-induced rat mammary carcinogenesis: Implications of molecular mechanisms.

  2024cites this paper
• Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly Available in Vivo, in Vitro, and in Silico Data

  2024cites this paper
• Subtypes of high-grade breast ductal carcinoma in situ (DCIS): incidence and potential clinical impact

  2023cites this paper
• The mutational landscape of the adult healthy parous and nulliparous human breast

  2023cites this paper
• Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq

  2023cites this paper
• WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

  2023cites this paper
• Oncobiology and treatment of breast cancer in young women

  2022cites this paper
• Is There a Relationship between Diet and Breast Cancer in Postmenopausal Women?

  2022cites this paper
• Effect of phases of the menstrual cycle on biophysical and biochemical parameters of African black women with breast cancer

  2022cites this paper
• Potential of chimeric antigen receptor (CAR)‐redirected immune cells in breast cancer therapies: Recent advances

  2022cites this paper
• Physiological background parenchymal uptake of 18F-FDG in normal breast tissues using dedicated breast PET: correlation with mammographic breast composition, menopausal status, and menstrual cycle

  2022cites this paper
• Ovarian Tissue Banking to Postpone Menopause

  2022cites this paper
• WNT4 balances development versus disease in gynecologic tissues and women's health.

  2021cites this paper
• Effects of menopausal hormone therapy-based on the role of estrogens, progestogens, and their metabolites in proliferation of breast cancer cells

  2021cites this paper
• Type 1 Nuclear Receptor Activity in Breast Cancer: Translating Preclinical Insights to the Clinic

  2021cites this paper
• Roles and action mechanisms of WNT4 in cell differentiation and human diseases: a review

  2021cites this paper
• A review on recent trends in the removal of emerging contaminants from aquatic environment using low-cost adsorbents.

  2021cites this paper
• Decrease in Cell Viability of Breast Cancer Cells by a Di-Hydroxylated Derivative of N-(2-hydroxyphenyl)-2-Propylpentanamide.

  2021cites this paper
• Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors

  2021influential citation
• Progesterone receptors in normal breast development and breast cancer.

  2021cites this paper
• ROLE OF SEX HORMONES IN MODULATING BREAST AND OVARIAN CANCER ASSOCIATED PAIN.

  2021cites this paper
• Progesterone Receptors Promote Quiescence & Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.

  2021cites this paper
• US EPA’s regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects

  2020cites this paper
• Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy

  2020cites this paper
• Progesterone and breast.

  2020cites this paper
• Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast

  2020cites this paper
• A modern look at the molecular-biological mechanisms of breast tumours in dogs

  2020cites this paper
• Epithelial–Mesenchymal Transition Programs and Cancer Stem Cell Phenotypes: Mediators of Breast Cancer Therapy Resistance

  2020influential citation
• Progesterone receptor membrane component 1 is required for mammary gland development†

  2020cites this paper
• Pathogenesis of ovarian cancer

  2020cites this paper
• Probing variations of fibrous structures during the development of breast ductal carcinoma tissues via Mueller matrix imaging.

  2020cites this paper
• Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats

  2020cites this paper
• WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway

  2020cites this paper
• WNT4, a potential biomarker in serum for colorectal cancer, promotes metastasis through WNT4/β-catenin pathway

  2020cites this paper
• Di(2-ethylhexyl) phthalate (DEHP) increases proliferation of epithelial breast cancer cells through progesterone receptor dysregulation.

  2019cites this paper
• Mueller polarimetric imaging for characterizing the collagen microstructures of breast cancer tissues in different genotypes

  2019cites this paper
• Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion

  2019cites this paper
• Development of topological tools for the analysis of biological data

  2018cites this paper
• WNT4 and WNT3A activate cell autonomous Wnt signaling independent of PORCN and secretion

  2018cites this paper
• Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis

  2018cites this paper
• Discharges and Secretions of the Nipple

  2018cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1491 Sentinel Node Biopsy for Breast Cancer Aspects and evolution

  2018cites this paper
• Progesterone receptor expression in proliferating cancer cells of hormone-receptor-positive breast cancer.

  2018cites this paper
• Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish.

  2018cites this paper
• Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer Wnt4 to Normoxic Cells to Elicit a Prometastatic Phenotype

  2018cites this paper
• Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women

  2018cites this paper
• Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms

  2018cites this paper
• Non-autonomous cell proliferation in the mammary gland and cancer.

  2017cites this paper
• Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary

  2017cites this paper
• Effects of breast cancer hormone treatment on lipids and subsequent cardiovascular diseases

  2017cites this paper
• Association of Cytokines and Chemokines in Pathogenesis of Breast Cancer.

  2017cites this paper
• Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

  2017cites this paper
• Current Approaches to Diagnosis and Treatment of Ductal Carcinoma In Situ and Future Directions.

  2017cites this paper
• Targeting progesterone metabolism in breast cancer with l-proline derived new 14-azasteroids.

  2017cites this paper
• Polymorphisms in TIM-3 and breast cancer susceptibility in Chinese women: A case-control study

  2016cites this paper
• Mammary Development and Breast Cancer: A Wnt Perspective

  2016cites this paper
• WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines

  2016cites this paper
• Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy

  2016cites this paper
• Peroral Estradiol Is Sufficient to Induce Carcinogen-Induced Mammary Tumorigenesis in Ovariectomized Rats without Progesterone

  2016cites this paper
• The Risk of Breast Cancer in Women Using Menopausal Hormone Replacement Therapy in Taiwan

  2016cites this paper
• Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy.

  2016cites this paper
• Low‐Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

  2016cites this paper
• Dissecting the Biology of Menstrual Cycle-Associated Breast Cancer Risk

  2016cites this paper
• Elucidating mechanisms that drive increased tumorigenesis in rats exposed to alcohol in utero

  2016cites this paper
• Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.

  2015cites this paper
• Prenatal Programming and Endocrinology.

  2015cites this paper
• Hormone Signaling Requirements for the Conversion of Non-Mammary Mouse Cells to Mammary Cell Fate(s) in Vivo

  2015cites this paper