Antifungal activity of five species of Polygala

Crude extracts and fractions of five species of Polygala – P. campestris, P. cyparissias, P. paniculata, P. pulchella and P. sabulosa – were investigated for their in vitro antifungal activity against opportunistic Candida species, Cryptococcus gattii and Sporothrix schenckii with bioautographic and microdilution assays. In the bioautographic assays, the major extracts were active against the fungi tested. In the minimal concentration inhibitory (MIC) assay, the hexane extract of P. paniculata and EtOAc fraction of P. sabulosa showed the best antifungal activity, with MIC values of 60 and 30 μg/mL, respectively, against C. tropicalis, C. gattii and S. schenckii. The compounds isolated from P. sabulosa prenyloxycoumarin and 1,2,3,4,5,6-hexanehexol displayed antifungal activity against S. schenckii (with MICs of 125 μg/mL and 250 μg/mL, respectively) and C. gattii (both with MICs of 250 μg/mL). Rutin and aurapten isolated from P. paniculata showed antifungal activity against C. gattii with MIC values of 60 and 250 μg/mL, respectively. In the antifungal screening, few of the isolated compounds showed good antifungal inhibition. The compound α-spinasterol showed broad activity against the species tested, while rutin had the best activity with the lowest MIC values for the microorganisms tested. These two compounds may be chemically modified by the introduction of a substitute group that would alter several physico-chemical properties of the molecule, such as hydrophobicity, electronic density and steric strain.

• Publication year

  2011

• Venue

  Brazilian Journal of Microbiology

• Publication date

  2011-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1590/S1517-838220110003000027PMID 24031724PMCID 3768791
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Triterpene saponins of the root bark of Olax obtusifolia De Wild

  2018cited by this paper
• Biological control of postharvest diseases of fruits and vegetables by microbial antagonists: A review

  2009cited by this paper
• Rutin has therapeutic effect on septic arthritis caused by Candida albicans.

  2009cited by this paper
• Trypanocidal activity of coumarins and styryl-2-pyrones from Polygala sabulosa A.W. Bennett (Polygalaceae)

  2008cited by this paper
• Antinociceptive effect of the Polygala sabulosa hydroalcoholic extract in mice: evidence for the involvement of glutamatergic receptors and cytokine pathways.

  2008cited by this paper
• Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites

  2008cited by this paper
• Biosynthesis of scopoletin and scopolin in cassava roots during post-harvest physiological deterioration: the E-Z-isomerisation stage.

  2008cited by this paper
• Inhibitory effect of extracts from Brazilian medicinal plants on the adhesion of Candida albicans to buccal epithelial cells

  2008cited by this paper
• Antifungal properties of plants used in Brazilian traditional medicine against clinically relevant fungal pathogens

  2007cited by this paper
• Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae), a folk medicine topical anesthetic.

  2007cited by this paper
• Sporotrichosis.

  2007cited by this paper
• Antiinflammatory activity of Polygala japonica extract.

  2006cited by this paper
• Antifungal capacity of major phenolic compounds of Olea europaea L. against Phytophthora megasperma drechsler and cylindrocarpon Destructans (Zinssm.) scholten

  2006cited by this paper
• Tricornoses A-L, oligosaccharide multi-esters from the roots of Polygala tricornis.

  2005cited by this paper
• Antimicrobial activity of some medicinal plants of the island Soqotra.

  2005cited by this paper
• Antifungal activity of some Brazilian Hypericum species.

  2005cited by this paper
• Antifungal activities of six South African Terminalia species (Combretaceae).

  2005cited by this paper
• Xanthones from the roots of Polygala caudata and their antioxidation and vasodilatation activities in vitro.

  2005cited by this paper
• Cryptococcus gattii in AIDS Patients, Southern California

  2005cited by this paper
• Interaction between saquinavir and antimycotic drugs on C. albicans and C. neoformans strains.

  2004cited by this paper
• A new styryl-2-pyrone derivative from Polygala sabulosa (Polygalaceae)

  2004cited by this paper
• A novel flavonoid from Polygala chinensis

  2004cited by this paper
• Xanthones from Polygala alpestris (Rchb.)

  2004cited by this paper
• Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.

  2004cited by this paper
• Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia.

  2004cited by this paper
• Two Xanthones from Polygala paniculata and Confirmation of the 1-Hydroxy- 2,3,5-trimethoxy-xanthone at Trace Level by HRGC-MS

  2003cited by this paper
• New Acylated Triterpene Saponins from Polygala arenaria

  2003cited by this paper
• Screening of traditionally used South African plants for antifungal activity against Candida albicans.

  2003cited by this paper
• Trypanocidal activity of extracts from Brazilian Atlantic Rain Forest plant species.

  2003cited by this paper
• Artefatos cumarínicos isolados de Polygala paniculata L. (Polygalaceae)

  2002cited by this paper
• Prevalence of Candida spp. in hospitalized patients and their risk factors

  2002cited by this paper
• Antifungal activity of Paraguayan plants used in traditional medicine.

  2001cited by this paper
• Styryl- and dihydrostyryl-2-pyrones derivatives from Polygala sabulosa.

  2000cited by this paper
• Synthesis and antifungal activity of coumarins and angular furanocoumarins.

  1999cited by this paper
• In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by ethnobotanically selected South African plants.

  1999cited by this paper
• In vitro effect of the extract and the 1,7-dihydroxy-2,3-dimethoxy xanthone from Polygala cyparissias on the contractions induced by inflammatory mediators and ovalbumin in normal and actively sensitised trachea from guinea pig

  1999cited by this paper
• Three xanthones from Polygala cyparissias

  1998cited by this paper
• Isolation of Polyphenols fromPolygala gazensis and Liquid Chromatography-Mass Spectrometry of Related AfricanPolygala Species

  1997cited by this paper
• Antifungal activity of scopoletin and its differential accumulation in Ulmus pumila and Ulmus campestris cell suspension cultures infected with Ophiostoma ulmi spores

  1997cited by this paper
• Oligosaccharide polyesters from roots of Polygala fallax.

  1997cited by this paper
• Xanthones from Polygala nyikensis

  1993cited by this paper
• Multicenter evaluation of four methods of yeast inoculum preparation

  1988cited by this paper
• Coumarins from Polygala paniculata

  1985cited by this paper
• A New Pyranocoumarin Diester from Polygala paniculata L

  1984cited by this paper

• Antibacterial potential of rutin nanoformulations: Current insights and future directions.

  2026cites this paper
• Analysis of Polyphenols from Polygala major Jacq.

  2025cites this paper
• Herbal Agents Against Dermatophytes: Effect of 43 Herbal Agents on Dermatophyte Growth

  2024cites this paper
• The Ethanolic Extract of Polygala paniculata L. Blocks Panx1 Channels and Reduces Ischemic Brain Infarct in a Dose- and Sex-Dependent Way

  2024cites this paper
• Chemical compounds investigation and profiling of antimicrobial and antiviral constituents of Tephrosia purpurea subsp. apollinea

  2024cites this paper
• Rutin: Chemical properties, Pharmacokinetic properties, Biological activities

  2024cites this paper
• Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

  2024cites this paper
• Phenolic and flavonoid compounds from leaves and branches of Schotia brachypetala for the development of biofungicide for wood protection

  2024cites this paper
• Rutin impedes human low-density lipoprotein from non-enzymatic glycation: A mechanistic insight against diabetes-related disorders.

  2023cites this paper
• Antiplasmodial activity of coumarins isolated from Polygala boliviensis: in vitro and in silico studies

  2023cites this paper
• Atividade antifúngica in vitro do extrato etanólico de Mikania cf hirsutissima contra isolados de Candida albicans

  2022cites this paper
• Pharmacology of α‐spinasterol, a phytosterol with nutraceutical values: A review

  2022cites this paper
• Isolation, Characterization and In Silico Studies of Secondary Metabolites from the Whole Plant of Polygala inexpectata Peşmen & Erik

  2022cites this paper
• İç Batı Anadoludan Toplanan Üç Ahlat Türlerünün Antimikrobiyal Etkilerinin Belirlenmesi

  2021cites this paper
• Polygala sabulosa A.W. Bennett extract mitigates motor and cognitive deficits in a mouse model of acute ischemia

  2021cites this paper
• Extraction of phenolic compounds from black mustard (Brassica nigra L.) seed by deep eutectic solvents

  2021cites this paper
• Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects

  2021cites this paper
• Characterization of Phytoconstituents from Alcoholic Extracts of Four Woody Species and Their Potential Uses for Management of Six Fusarium oxysporum Isolates Identified from Some Plant Hosts

  2021cites this paper
• Screening of 20 Pantanal Wetland Plants for Anti-Candida Activity using HPLC-DAD-MS/MS and Bioautography to Characterize Active Compounds

  2021cites this paper
• Methyl salicylate as a signaling compound that contributes to forest ecosystem stability

  2021cites this paper
• Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes

  2021cites this paper
• Antimicrobial Efficacy of Vitellaria paradoxa fractions and compounds on some wood Fungi and Bacteria

  2021cites this paper
• New Insights into the Antioxidant Compounds of Achenes and Sprouted Buckwheat Cultivated in the Republic of Moldova

  2021cites this paper
• Nutraceutical-Loaded Chitosan Nanoparticles for Healthcare Applications

  2020cites this paper
• Therapeutic benefits of rutin and its nanoformulations

  2020cites this paper
• Secondary Metabolites from Plant Sources

  2020cites this paper
• Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity

  2020cites this paper
• Metabolic flux analysis of secondary metabolism in plants

  2020cites this paper
• Nanomedicine for Bioactives: Healthcare applications

  2020cites this paper
• Assessment of Polygala paniculata (Polygalaceae) characteristics for evolutionary studies of legume–rhizobia symbiosis

  2019cites this paper
• A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

  2019cites this paper
• Antifungal and Antibacterial Activities of Wood Treated with Musa paradisiaca L. Peel Extract: HPLC Analysis of Phenolic and Flavonoid Contents

  2019cites this paper
• Looking for new antifungal drugs from flavonoids: impact of the genetic diversity of Candida albicans on the in-vitro response.

  2019cites this paper
• Antifungal Activity of Compounds obtained from Sawdust and Stem Bark of Sasswood Tree (Erythrophleum suaveolens) on Wood Rot Fungi

  2019cites this paper
• Molecular insight into binding behavior of polyphenol (rutin) with beta lactoglobulin: Spectroscopic, molecular docking and MD simulation studies

  2018cites this paper
• Could flavonoids compete with synthetic azoles in diminishing Candida albicans infections?

  2018cites this paper
• Study of sodium 3-hydroxycoumarin as inhibitors in vitro, in vivo and in silico of Moniliophthora perniciosa fungus

  2018cites this paper
• A new xanthone as a chemical marker of four Polygala species (Polygalaceae)

  2018cites this paper
• Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants

  2018cites this paper
• Ailanthusins A-G and nor-lupane triterpenoids from Ailanthus triphysa.

  2017cites this paper
• Anti- Sporothrix spp. activity of medicinal plants

  2016influential citation
• The Pharmacological Potential of Rutin

  2016cites this paper
• Phenolic composition and anticholinesterase, antioxidant, antifungal and antibiotic modulatory activities of Prockia crucis (Salicaceae) extracts collected in the Caatinga biome of Ceará State, Brazil

  2015cites this paper
• Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.

  2015cites this paper
• Antioxidant capacity and phenolic content of commonly used anti-inflammatory medicinal plants in Colombia

  2015cites this paper
• Polygala molluginifolia A. St.-Hil. and Moq. prevent inflammation in the mouse pleurisy model by inhibiting NF-κB activation.

  2014cites this paper
• Rutin: therapeutic potential and recent advances in drug delivery

  2013cites this paper
• Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity

  2013cites this paper
• Evaluation of antibiotic & antibiotic modifying activity of pilocarpine & rutin

  2012cites this paper
• Evaluation of in vitro antileishmanial and antimycobacterial activities of Stifftia chrysantha J.C. Mikan extracts

  2012cites this paper