Developmental neurobiology of the zebrafish

How does the nervous system develop? This problem has intrigued embryologists for more than a century. In fact, early investigators formulated many of the fundamental questions about how the nervous system arises, how neurons acquire their identities, and how neuronal processes find and form synapses with appropriate target cells. To answer these questions, it would be ideal to have a single species with which cellular, molecular, and genetic analyses could be carried out on individually identified neurons and their associated cells as they develop and generate a complex nervous system. The zebrafish (Brachydunio rerio) has the potential to be such a species. In this essay, I will discuss aspects of the zebrafish that make its embryo an excellent material for developmental studies, results that have extended our knowledge of nervous system development, and future prospects for this work.

• Publication year

  1991

• Venue

  Journal of Neuroscience

• Publication date

  1991-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.11-02-00311.1991PMID 1992002PMCID PMC6575211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Murine developmental control genes.

  1990influential reference
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1989influential reference
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  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
• Spatial patterns of homeobox gene expression in the developing mammalian CNS.

  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986influential reference
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  1986cited by this paper
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  1986cited by this paper
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  1986influential reference
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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1982cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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  1980cited by this paper
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  2012cites this paper
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  2012cites this paper
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  2010cites this paper
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  2009cites this paper
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  2008cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2004cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1994cites this paper
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  1994cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper