A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects

Thomas Nickl-Jockschat,T. Stöcker,A. Krug,V. Markov,Ruiwang Huang,F. Schneider,U. Habel,S. Eickhoff,K. Zerres,M. Nöthen,J. Treutlein,M. Rietschel,N. Shah,T. Kircher

Published 2014 in Brain and Behavior

ABSTRACT

Changes in fiber tract architecture have gained attention as a potentially important aspect of schizophrenia neuropathology. Although the exact pathogenesis of these abnormalities yet remains to be elucidated, a genetic component is highly likely. Neuregulin‐1 (NRG1) is one of the best‐validated schizophrenia susceptibility genes. We here report the impact of the Neuregulin‐1 rs35753505 variant on white matter structure in healthy young individuals with no family history of psychosis.

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