Genetic predisposition and early life experience interact to determine glutamate transporter (GLT1) and solute carrier family 12 member 5 (KCC2) levels in rat hippocampus

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Metabolic brain disease

• Publication date

  2016-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1007/s11011-015-9742-5PMID 26464063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex.

  2015cited by this paper
• Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.

  2015cited by this paper
• Impaired Energy Metabolism and Disturbed Dopamine and Glutamate Signalling in the Striatum and Prefrontal Cortex of the Spontaneously Hypertensive Rat Model of Attention-Deficit Hyperactivity Disorder

  2015cited by this paper
• Prenatal stress and its effects on the fetus and the child: possible underlying biological mechanisms.

  2015cited by this paper
• Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health.

  2015cited by this paper
• Brain γ‐aminobutyric acid: a neglected role in impulsivity

  2014influential reference
• Glutamatergic dysregulation in pediatric psychiatric disorders: a systematic review of the magnetic resonance spectroscopy literature.

  2014cited by this paper
• Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

  2014cited by this paper
• Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons

  2014cited by this paper
• Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.

  2014cited by this paper
• Maternal separation increases GABA(A) receptor-mediated modulation of norepinephrine release in the hippocampus of a rat model of ADHD, the spontaneously hypertensive rat.

  2013influential reference
• Evidence for reduced tonic levels of GABA in the hippocampus of an animal model of ADHD, the spontaneously hypertensive rat.

  2013influential reference
• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• Synaptic Dysfunction in Depression: Potential Therapeutic Targets

  2012cited by this paper
• Clozapine decreases exploratory activity and increases anxiety-like behaviour in the Wistar-Kyoto rat but not the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.

  2012cited by this paper
• Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus.

  2012cited by this paper
• Effects of early life trauma are dependent on genetic predisposition: a rat study

  2011cited by this paper
• Maternal separation affects dopamine transporter function in the Spontaneously Hypertensive Rat: An in vivo electrochemical study

  2011cited by this paper
• Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-Maze in C57BL/6J mice

  2011cited by this paper
• Molecular genetics of attention deficit hyperactivity disorder.

  2010cited by this paper
• Cross-fostering does not alter the neurochemistry or behavior of spontaneously hypertensive rats

  2009cited by this paper
• Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene–environment interplay

  2009influential reference
• Cation-chloride cotransporters and neuronal function.

  2009cited by this paper
• Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus.

  2009cited by this paper
• SDS micelles as a membrane-mimetic environment for transmembrane segments.

  2009cited by this paper
• The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation.

  2009cited by this paper
• Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis

  2009cited by this paper
• Behavioral and Brain Functions

  2009cited by this paper
• Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse

  2009cited by this paper
• Eight-channel iTRAQ Enables Comparison of the Activity of Six Leukemogenic Tyrosine Kinases*S

  2008cited by this paper
• NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.

  2008cited by this paper
• Serotonin transporter gene and adverse life events in adult ADHD

  2008cited by this paper
• The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus

  2008cited by this paper
• Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attention-deficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat).

  2008influential reference
• iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

  2008cited by this paper
• Long‐term behavioural and molecular alterations associated with maternal separation in rats

  2007cited by this paper
• Genome-Wide Association

  2007cited by this paper
• Striatal Creatine and Glutamate/Glutamine in Attention-Deficit/Hyperactivity Disorder

  2007cited by this paper
• Shotgun proteomics using the iTRAQ isobaric tags.

  2006cited by this paper
• Variations in prevalence of attention deficit hyperactivity disorder worldwide

  2006cited by this paper
• Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission

  2006cited by this paper
• Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways.

  2006cited by this paper
• Cellular and subcellular mRNA localization of glutamate transporter isoforms GLT1a and GLT1b in rat brain by in situ hybridization

  2005cited by this paper
• Molecular genetics of attention-deficit/hyperactivity disorder.

  2005cited by this paper
• Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring

  2005cited by this paper
• Early life experience alters response of adult neurogenesis to stress

  2004cited by this paper
• Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression

  2004cited by this paper
• NMDA Receptor Function in the Prefrontal Cortex of a Rat Model for Attention-Deficit Hyperactivity Disorder

  2004cited by this paper
• Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking

  2004cited by this paper
• Neurometabolic functioning and neuropsychological correlates in children with ADHD-H: preliminary findings.

  2004cited by this paper
• Altered expression of the glutamate transporter EAAT2b in neurological disease

  2004cited by this paper
• Loss of glial glutamate transporters and induction of neuronal expression of GLT-1B in the hypoxic neonatal pig brain.

  2004cited by this paper
• Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation.

  2004cited by this paper
• Cl− uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

  2004cited by this paper
• Shotgun proteomics: integrating technologies to answer biological questions.

  2003cited by this paper
• Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

  2003influential reference
• The worldwide prevalence of ADHD: is it an American condition?

  2003cited by this paper
• Norepinephrine regulates locomotor hyperactivity in the mouse mutant coloboma.

  2003cited by this paper
• Mother's voice "buffers" separation-induced receptor changes in the prefrontal cortex of octodon degus.

  2003cited by this paper
• Proton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder.

  2003cited by this paper
• Maternal deprivation increases cell death in the infant rat brain.

  2002cited by this paper
• Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats.

  2002cited by this paper
• Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment

  2001cited by this paper
• GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition.

  2001influential reference
• Comparison of the effects of early handling and early deprivation on maternal care in the rat.

  2001cited by this paper
• Glutamate uptake.

  2001cited by this paper
• Increased AMPA Receptor Function in Slices Containing the Prefrontal Cortex of Spontaneously Hypertensive Rats

  2001cited by this paper
• Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.

  2001cited by this paper
• Brief vs. long maternal separations in infancy: contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety.

  2001cited by this paper
• The GLT‐1 and GLAST Glutamate Transporters Are Expressed on Morphologically Distinct Astrocytes and Regulated by Neuronal Activity in Primary Hippocampal Cocultures

  2000cited by this paper
• Increased Glutamate-Stimulated Norepinephrine Release from Prefrontal Cortex Slices of Spontaneously Hypertensive Rats

  2000cited by this paper
• Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)

  2000cited by this paper
• The neural cell adhesion molecule in synaptic plasticity and ageing

  2000cited by this paper
• Long-term behavioral and neuroendocrine adaptations to adverse early experience.

  2000cited by this paper
• Genetic influences on attention deficit hyperactivity disorder

  2000cited by this paper
• Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats.

  1999cited by this paper
• The Neuron-specific K-Cl Cotransporter, KCC2

  1999cited by this paper
• Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains.

  1999cited by this paper
• Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation.

  1999cited by this paper
• The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats.

  1999cited by this paper
• The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

  1999cited by this paper
• Alternative splicing of the glutamate transporter EAAT2 (GLT-1).

  1998cited by this paper
• Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat.

  1998cited by this paper
• Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain.

  1997cited by this paper
• Tissue specific variants of glutamate transporter GLT‐1

  1997cited by this paper
• Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.

  1997cited by this paper
• Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it.

  1996cited by this paper
• Brain Glutamate Transporter Proteins Form Homomultimers*

  1996influential reference
• The neural cell adhesion molecule and synaptic plasticity.

  1995cited by this paper
• Potentiation of isolation-induced vocalization by brief exposure of rat pups to maternal cues.

  1994cited by this paper
• Co‐expression of GFAP and vimentin in astrocytes proliferating in response to injury in the mouse cerebral hemisphere. A combined autoradiographic and double immunocytochemical study

  1993cited by this paper
• Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats.

  1993cited by this paper
• An [Na+ + K+]coupled L-glutamate transporter purified from rat brain is located in glial cell processes.

  1992cited by this paper
• Cytoskeleton--plasma membrane interactions.

  1992cited by this paper
• Effects of repeated maternal separations on the adrenocortical response to stress of preweanling rats.

  1992cited by this paper
• Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles.

  1976influential reference
• VU Research Portal Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations

  year unknowncited by this paper

• Proteomic Findings in ADHD: A Systematic Review.

  2025cites this paper
• Early maternal separation potentiates the impact of later social isolation in inducing depressive-like behavior via oxidative stress in adult rats

  2025cites this paper
• Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.

  2024cites this paper
• Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor

  2022cites this paper
• Maternal separation affects Anxiety like behavior begin in adolescence continue through adulthood and related to Dnmt3a expression.

  2022cites this paper
• Novel plasma metabolite markers of attention-deficit/hyperactivity disorder identified using high-performance chemical isotope labelling-based liquid chromatography-mass spectrometry

  2020cites this paper
• Alterations in chloride transporter activity in stress and depression

  2020cites this paper
• iTRAQ quantitatively proteomic analysis of the hippocampus in a rat model of accumulative microwave-induced cognitive impairment

  2019cites this paper
• Impact of autism-associated genetic variants in interaction with environmental factors on ADHD comorbidities: an exploratory pilot study

  2019cites this paper
• Perinatal compromise contributes to programming of GABAergic and glutamatergic systems leading to long‐term effects on offspring behaviour

  2019cites this paper
• Sex Differences in Psychiatric Disease: A Focus on the Glutamate System

  2018cites this paper
• Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis

  2016cites this paper
• Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-D-Aspartate Receptors Systems.

  2016cites this paper
• Genetically determined differences in noradrenergic function: The spontaneously hypertensive rat model.

  2016cites this paper