Sarcoplasmic Reticulum Ca2+ Release Is Not a Dominating Factor in Sinoatrial Node Pacemaker Activity

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Circulation Research

• Publication date

  2003-02-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.RES.0000055904.21974.BEPMID 12595347
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heterogeneous Expression of Ca2+ Handling Proteins in Rabbit Sinoatrial Node

  2002cited by this paper
• &bgr;-Adrenergic Stimulation Modulates Ryanodine Receptor Ca2+ Release During Diastolic Depolarization to Accelerate Pacemaker Activity in Rabbit Sinoatrial Nodal Cells

  2002cited by this paper
• beta-modulation of pacemaker rate: novel mechanism or novel mechanics of an old one?

  2002cited by this paper
• Pacemaker Shift in the Rabbit Sinoatrial Node in Response to Vagal Nerve Stimulation

  2001cited by this paper
• Sinoatrial Nodal Cell Ryanodine Receptor and Na + -Ca 2+ Exchanger: Molecular Partners in Pacemaker Regulation

  2001cited by this paper
• Modulation of Delayed Rectifier Potassium Current, IK, by Isoprenaline in Rabbit Isolated Pacemaker Cells

  2000cited by this paper
• The sinoatrial node, a heterogeneous pacemaker structure.

  2000cited by this paper
• Characterisation of the transient outward K+ current in rabbit sinoatrial node cells.

  2000cited by this paper
• Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.

  2000cited by this paper
• How does β‐adrenergic stimulation increase the heart rate? The role of intracellular Ca2+ release in amphibian pacemaker cells

  1999cited by this paper
• Downward gradient in action potential duration along conduction path in and around the sinoatrial node.

  1999cited by this paper
• Intracellular calcium and Na+‐Ca2+ exchange current in isolated toad pacemaker cells

  1998cited by this paper
• Low-frequency extracellular potentials recorded from the sinoatrial node.

  1998cited by this paper
• Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node.

  1997cited by this paper
• Electrophysiological actions of ryanodine on single rabbit sinoatrial nodal cells.

  1997cited by this paper
• Basal responses of the L‐type Ca2+ and hyperpolarization‐activated currents to autonomic agonists in the rabbit sino‐atrial node.

  1996cited by this paper
• Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea‐pig sino‐atrial node

  1996cited by this paper
• The sarcolemmal mechanisms involved in the control of diastolic intracellular calcium in isolated rat cardiac trabeculae

  1996cited by this paper
• A sustained inward current activated at the diastolic potential range in rabbit sino‐atrial node cells.

  1995cited by this paper

• A mechanistic investigation of the effects of lactic acidosis on myocardial contractility in the Neotropical fast-swimming freshwater fish Brycon amazonicus.

  2025cites this paper
• Probability that there is a mammalian counterpart of cardiac clock in insects.

  2022cites this paper
• Rad Modulation of the L-type Calcium Channel Confers Systolic Advantage in the Heart

  2021cites this paper
• Rad-GTPase contributes to heart rate via L-type calcium channel regulation.

  2021cites this paper
• Ultrastructure of primary pacemaking cells in rabbit sino‐atrial node cells indicates limited sarcoplasmic reticulum content

  2020cites this paper
• Limulus and heart rhythm.

  2018cites this paper
• Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

  2016cites this paper
• Ca2+ handling in a mice model of CPVT

  2016cites this paper
• The effects of RYR2 gene deletion on cardiac function and metabolism

  2016cites this paper
• β1-adrenoceptor blockade treatment of right ventricular dysfunction caused by pulmonary hypertension

  2015cites this paper
• Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells

  2015cites this paper
• Cellular Sinoatrial Node and Atrioventricular Node Activity in the Heart

  2014cites this paper
• Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity

  2014cites this paper
• SEM, TEM, and IHC Analysis of the Sinus Node and Its Implications for the Cardiac Conduction System

  2013cites this paper
• Fabrication of Straight Stainless-Steel Micro-Coils for the Use of Biodevice Components

  2013cites this paper
• Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification

  2013cites this paper
• The cardiac sodium-calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm.

  2013cites this paper
• Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

  2012cites this paper
• Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice.

  2012cites this paper
• Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models.

  2012cites this paper
• Ionic fluxes and genesis of the cardiac action potential

  2012cites this paper
• Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells.

  2011cites this paper
• Pacemaker activity in the insect (T. molitor) heart: role of the sarcoplasmic reticulum.

  2011cites this paper
• Beta-adrenergic receptor signaling in the heart: role of CaMKII.

  2010cites this paper
• Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium.

  2010cites this paper
• Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping.

  2010cites this paper
• Physical Principles of Optical Recordings From Complex Multilayer Tissues Such As Sinoatrial and Atrioventricular Nodes

  2010cites this paper
• A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper
• Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

  2009cites this paper
• receptors(RyR2s)ishypothesizedtocontributetoarrhythmogenesisinAF,butthemolecularmechanisms areincompletelyunderstood.Here,wehaveshownthatmicewithageneticgain-of-functiondefectinRyr2 (whichwetermedRyr2 R176Q/+ mice)didnotexhibitspontaneousAFbutthatrapidatrialpacingunmasked anincreasedvulnerabilitytoA

  2009cites this paper
• Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f).

  2009cites this paper
• Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

  2009cites this paper
• Calmodulin kinase II is required for fight or flight sinoatrial node physiology

  2009cites this paper
• Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells

  2009cites this paper
• Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

  2009cites this paper
• New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: diversity in the excitation-contraction mechanisms of the heart.

  2009cites this paper
• Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.

  2009influential citation
• Beating to time: calcium clocks, voltage clocks, and cardiac pacemaker activity.

  2009cites this paper
• Ionic mechanisms underlying the positive chronotropy induced by beta1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study.

  2008cites this paper
• Regional difference in dynamical property of sinoatrial node pacemaking: role of na+ channel current.

  2008cites this paper
• Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes.

  2008cites this paper
• New insights into pacemaker activity: promoting understanding of sick sinus syndrome.

  2007cites this paper
• Store-operated Ca2+ entry and TRPC expression; possible roles in cardiac pacemaker tissue.

  2007cites this paper
• Promoting Understanding of Sick Sinus Syndrome

  2007cites this paper
• Calcium and arrhythmogenesis.

  2007cites this paper
• The Pacemaker Current: From Basics to the Clinics

  2007cites this paper
• Pacemaker current (I(f)) in the human sinoatrial node.

  2007cites this paper
• The sinoatrial node is still setting the pace 100 years after its discovery.

  2007cites this paper
• Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia.

  2007cites this paper
• (If) in the human sinoatrial node

  2007cites this paper
• Bradycardia and Slowing of the Atrioventricular Conduction in Mice Lacking Ca V 3.1/ (cid:1) 1G T-Type Calcium Channels

  2006cites this paper
• Ryanodine does not produce negative chronotropic effect on action potential generation in heart pacemaker cells of young frogs Rana temporaria

  2006cites this paper
• The control of heart rate: the physiology of the sinoatrial node and the role of the I f current

  2006cites this paper
• Fundamental importance of Na+–Ca2+ exchange for the pacemaking mechanism in guinea‐pig sino‐atrial node

  2006cites this paper
• Molecular mapping of the rabbit atrioventricular node.

  2006cites this paper
• Bradycardia and Slowing of the Atrioventricular Conduction in Mice Lacking CaV3.1/&agr;1G T-Type Calcium Channels

  2006cites this paper
• Molecular physiology of cardiac repolarization.

  2005cites this paper
• Would modulation of intracellular Ca2+ be antiarrhythmic?

  2005cites this paper
• Ectopic activity induced by elevated atrial pressure in rabbit pulmonary vein in vitro.

  2005cites this paper
• Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.

  2004cites this paper
• Cellular Mechanisms of Sinoatrial Activity

  2004cites this paper
• Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control

  2004cites this paper
• Mutant cardiac ryanodine receptors and ventricular arrhythmias: is 'gain-of-function' obligatory?

  2004cites this paper
• Cyclic Variation of Intracellular Calcium: A Critical Factor for Cardiac Pacemaker Cell Dominance

  2003cites this paper
• The mouse sino‐atrial node expresses both the type 2 and type 3 Ca2+ release channels/ryanodine receptors

  2003cites this paper
• Cardiac pacemaking: If vs. Ca2+, is it really that simple?

  2003cites this paper
• I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells.

  2003cites this paper
• Dynamics of Cardiac Intracellular CA2+ Handling - from Experiments to Virtual Cells

  2003cites this paper
• The Electrophysiological Properties of Spontaneously Beating Pacemaker Cells Isolated from Mouse Sinoatrial Node

  2003cites this paper
• Cardiac pacemaking: I(f) vs. Ca(2+), is it really that simple?

  2003cites this paper
• Is timing everything? Therapeutic potential of modulators of cardiac Na+ transporters

  2003cites this paper
• Cholinergic Receptor Signaling Modulates Spontaneous Firing of Sinoatrial Nodal Cells via Integrated Effects on Pka-dependent Ca 2ϩ Cycling and I Kach Cholinergic Receptor Signaling Modulates Spontaneous Firing of Sinoatrial Nodal Cells via Integrated Effects on Pka-dependent Ca 2ϩ Cycling And

  year unknowncites this paper