Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Biology of the Cell

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E05-09-0895PMID 16624867PMCID PMC1483030
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy

  2005cited by this paper
• Membrane targeting of lipid modified signal transduction proteins.

  2004cited by this paper
• The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis.

  2004cited by this paper
• Dimerization of Cell Surface Receptors in Signal Transduction Review

  2004cited by this paper
• Osmotic stress, a proinflammatory signal in Caco-2 cells.

  2004cited by this paper
• Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.

  2004cited by this paper
• p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression.

  2004cited by this paper
• Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor*

  2004cited by this paper
• Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis

  2004cited by this paper
• The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.

  2003cited by this paper
• Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

  2003cited by this paper
• Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial Cells*

  2003cited by this paper
• Phosphatidylinositol 3-Kinase Controls Human Intestinal Epithelial Cell Differentiation by Promoting Adherens Junction Assembly and p38 MAPK Activation*

  2002cited by this paper
• NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells.

  2002cited by this paper
• Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.

  2002influential reference
• Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

  2002cited by this paper
• Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.

  2002cited by this paper
• Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways

  2002influential reference
• Differential localization of ErbB2 in different tissues of the rat female reproductive tract: Implications for the use of specific antibodies for ErbB2 analysis

  2001cited by this paper
• Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland.

  2001cited by this paper
• Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer

  2001cited by this paper
• Intestinal Epithelial Cell Differentiation Involves Activation of p38 Mitogen-activated Protein Kinase That Regulates the Homeobox Transcription Factor CDX2*

  2001cited by this paper
• Regulation of sialomucin complex/Muc4 expression in rat uterine luminal epithelial cells by transforming growth factor‐β: Implications for blastocyst implantation

  2000cited by this paper
• Signal transduction in mammary tumorigenesis: a transgenic perspective

  2000cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors.

  2000cited by this paper
• Evolutionary Analysis of the ErbB Receptor and Ligand Families

  2000cited by this paper
• Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells.

  1999cited by this paper
• Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis*

  1999cited by this paper
• p38 Mitogen-activated Protein Kinase Activation Is Required for Fibroblast Growth Factor-2-stimulated Cell Proliferation but Not Differentiation*

  1999cited by this paper
• Association of the Ras to Mitogen-activated Protein Kinase Signal Transduction Pathway with Microfilaments

  1999cited by this paper
• Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2*

  1999cited by this paper
• Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development.

  1999cited by this paper
• An Intramembrane Modulator of the ErbB2 Receptor Tyrosine Kinase That Potentiates Neuregulin Signaling*

  1999cited by this paper
• p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

  1999cited by this paper
• Carbohydrate‐mediated Golgi to cell surface transport and apical targeting of membrane proteins

  1998cited by this paper
• Specificity within the EGF family/ErbB receptor family signaling network

  1998cited by this paper
• A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini*

  1998cited by this paper
• Requirement of p38 Mitogen-activated Protein Kinase for Neuronal Differentiation in PC12 Cells*

  1998cited by this paper
• Post-transcriptional Regulation of a Milk Membrane Protein, the Sialomucin Complex (Ascites Sialoglycoprotein (ASGP)-1/ASGP-2, Rat Muc4), by Transforming Growth Factor β*

  1998cited by this paper
• ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

  1997cited by this paper
• Reversible Disruption of Cell-Matrix and Cell-Cell Interactions by Overexpression of Sialomucin Complex*

  1997cited by this paper
• Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation

  1997cited by this paper
• The Apical Submembrane Cytoskeleton Participates in the Organization of the Apical Pole in Epithelial Cells

  1997cited by this paper
• Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

  1997cited by this paper
• The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

  1997cited by this paper
• Sialomucin Complex, a Heterodimeric Glycoprotein Complex

  1996cited by this paper
• PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine.

  1995cited by this paper
• The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

  1995cited by this paper
• The dynamic role of palmitoylation in signal transduction.

  1995cited by this paper
• A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.

  1995cited by this paper
• Requirement for neuregulin receptor erbB2 in neural and cardiac development

  1995cited by this paper
• Dimerization of cell surface receptors in signal transduction.

  1995cited by this paper
• Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

  1995cited by this paper
• SH2/SH3 signaling proteins.

  1994cited by this paper
• A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.

  1994cited by this paper
• Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

  1994cited by this paper
• A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.

  1993cited by this paper
• Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily.

  1992cited by this paper
• Isolation and partial characterization of ascites sialoglycoprotein-2 of the cell surface sialomucin complex of 13762 rat mammary adenocarcinoma cells.

  1990cited by this paper
• Biosynthesis of the cell surface sialomucin complex of ascites 13762 rat mammary adenocarcinoma cells from a high molecular weight precursor.

  1990cited by this paper
• Functional analysis of the ligand binding site of EGF‐receptor utilizing chimeric chicken/human receptor molecules.

  1989cited by this paper
• Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha

  1988cited by this paper
• On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

  1987cited by this paper
• A complex of two cell surface glycoproteins from ascites mammary adenocarcinoma cells.

  1980cited by this paper
• Purification of the major sialoglycoproteins of 13762 MAT-B1 and MAT-C1 rat ascites mammary adenocarcinoma cells by density gradient centrifugation in cesium chloride and guanidine hydrochloride.

  1980cited by this paper

• Immunomodulatory properties of transmembrane mucins: from chronic diseases to cancer.

  2025cites this paper
• Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment

  2023cites this paper
• Pathological implications of mucin signaling in metastasis.

  2023cites this paper
• MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans.

  2021cites this paper
• The role of membrane mucin MUC4 in breast cancer metastasis.

  2021cites this paper
• The expression of P2Y6 receptor promotes the quality of mucus in colitic mice

  2021cites this paper
• Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression

  2021cites this paper
• Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer

  2021cites this paper
• Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells

  2020influential citation
• Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients.

  2019cites this paper
• Dysfunctional ErbB2, an EGF receptor family member, in asthmatic airway epithelial cells critically hinders repair after mechanical wounding

  2019cites this paper
• Mucin-4: A novel marker for oral cancer

  2019cites this paper
• Intracellular sequestration of HER2 via targeted subcellular peptide delivery

  2018cites this paper
• Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets.

  2018cites this paper
• Cervico-vaginal mucus (CVM) – an accessible source of immunologically informative biomolecules

  2018cites this paper
• Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells.

  2017cites this paper
• ERBB2 as a driver of an invasive phenotype of cells grown in 3D culture and an important regulator of oncogenic miRNAs' expression in breast cancer

  2017cites this paper
• MUC4 impairs the anti‐inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps

  2017cites this paper
• Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms

  2016cites this paper
• Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas

  2016cites this paper
• PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2

  2016cites this paper
• Investigation of swine dysentery associated with "Brachyspira hampsonii" strain EB107 and comparison of diagnostic methods

  2014cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
• Comparison of Lesion Severity, Distribution, and Colonic Mucin Expression in Pigs With Acute Swine Dysentery Following Oral Inoculation With “Brachyspira hampsonii” or Brachyspira hyodysenteriae

  2014cites this paper
• MUC 4 stabilizes HER 2 expression and maintains the cancer stem cell population in ovarian cancer cells

  2014cites this paper
• Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: new insight into the presence of the transcript variant of MUC4.

  2014cites this paper
• Imaging , Diagnosis , Prognosis MUC 4-MediatedRegulation of Acute PhaseProtein Lipocalin 2 through HER 2 / AKT / NFk B Signaling in Pancreatic Cancer

  2014cites this paper
• Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions

  2014cites this paper
• Lipopolysaccharide induces a stromal-epithelial signalling axis in a rat model of chronic periodontitis.

  2013cites this paper
• Retinoid Signaling in Cancer and its Promise for Therapy

  2013cites this paper
• MUC4-Mediated Regulation of Acute Phase Protein Lipocalin 2 through HER2/AKT/NF-κB Signaling in Pancreatic Cancer

  2013cites this paper
• Investigating breast cancer O-linked glycosylation changes and their immunotherapeutic potential

  2013cites this paper
• Pathogenesis of Human Enterovirulent Bacteria: Lessons from Cultured, Fully Differentiated Human Colon Cancer Cell Lines

  2013cites this paper
• Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer

  2013cites this paper
• EGFR/HER-targeted therapeutics in ovarian cancer.

  2012cites this paper
• MUC4: A novel prognostic factor of oral squamous cell carcinoma

  2012cites this paper
• Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies

  2012cites this paper
• TGF-β and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells.

  2012cites this paper
• TGF-and Smad 3 modulate PI 3 K / Akt signaling pathway in vascular smooth muscle cells

  2012cites this paper
• The role of Nrg1-ErbB signaling in promoting Schwann cell myelination

  2012cites this paper
• TGF- (cid:1) and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells

  2012cites this paper
• Anticorps anti-muc16 et leurs procédés d'utilisation

  2011cites this paper
• MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells

  2011cites this paper
• Recent advances in mucin immunohistochemistry in salivary gland tumors and head and neck squamous cell carcinoma.

  2011cites this paper
• MUC4 (mucin 4, cell surface associated)

  2011cites this paper
• Novel Monoclonal Antibodies Against the Proximal (Carboxy-Terminal) Portions of MUC16

  2010cites this paper
• Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF‐β

  2010cites this paper
• Mechanistic and signaling analysis of Muc4–ErbB2 signaling module: New insights into the mechanism of ligand‐independent ErbB2 activity

  2010cites this paper
• MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies.

  2010cites this paper
• Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions

  2010cites this paper
• Effect of Stress on Mucin Expression in the Gastrointestinal Tract of Mice.

  2010cites this paper
• Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination

  2010cites this paper
• Expression of MUC1 and MUC4 and Its Prognostic Significance in Non-Small Cell Lung Carcinoma

  2010cites this paper
• Muc4, the Integral Membrane Modulator of ErbB2:The Effects of Muc4 Expression on ErbB2 and ErbB3 Phosphorylation, Receptor Levels and Sub-Cellular Localization In Breast Cancer Cells Treated With Neuregulin

  2010influential citation
• Regulation of SMC/MUC4 Expression in the Airway

  2010influential citation
• Kwon Expression of MUC 1 and MUC 4 and Its Prognostic Significance in Non-Small Cell Lung Carcinoma

  2010cites this paper
• Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

  2010cites this paper
• Early response to ErbB2 over‐expression in polarized Caco‐2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling

  2010influential citation
• MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury

  2009cites this paper
• Translating Basic Research Into Clinical Practice Mucins , Mucus , and Sputum *

  2009cites this paper
• TGFβ regulation of membrane mucin Muc4 via proteosome degradation

  2009cites this paper
• The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.

  2009cites this paper
• Muc4/MUC4 functions and regulation in cancer.

  2009cites this paper
• Mucus Hypersecretion, MUC genes and Mucins in Inflammatory Nasosinusal Diseases. Regulation by Proinflammatory and Antiinflammatory Agents

  2008cites this paper
• Structure and function of the cell surface (tethered) mucins.

  2008cites this paper
• Structure, evolution, and biology of the MUC4 mucin

  2008cites this paper
• MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells

  2008cites this paper
• Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro.

  2007cites this paper
• Molecular signaling in the regulation of mucins

  2007cites this paper
• Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways.

  2007cites this paper
• Sequestration and Segregation of Receptor Kinases in Epithelial Cells: Implications for ErbB2 Oncogenesis

  2007cites this paper
• Signaling mucins: the new kids on the MAPK block.

  2007cites this paper
• Cell surface-associated mucins in signal transduction.

  2006cites this paper
• Muc4 Expression During Blood Vessel Formation in Damaged Rat Cornea

  2006cites this paper
• Membrane Mucin Muc4 Induces Density-dependent Changes in ERK Activation in Mammary Epithelial and Tumor Cells

  2006cites this paper