The effect of osmotic pressure on succinoxidase activity.

Structural damage to mitochondria is known to cause diverse effects on the activities of enzymes linked to those particles (2). Some systems are activated or have their activity enhanced by many procedures damaging to the mitochondria, while others suffer considerable loss in activity (2). Hypotonic solutions are frequently employed to disrupt structural integrity, and, when increases in activity occur as a result of treatment with such solutions, it is a commonplace to attribute the phenomenon to an alteration in permeability. However, with a few exceptions (3, 4), most studies of this kind ignore the possibility that, independently of their effects on the structure or membrane permeability, media of different osmotic pressures may exert also a direct physical action on the enzyme. In this report we shall show that the activity of the succinoxidase complex is affected by the osmotic pressure of the medium, irrespective of the structural state of the mitochondria.

• Publication year

  1954

• Venue

  Journal of Biological Chemistry

• Publication date

  1954-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(18)65518-8PMID 13192144
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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