Magnesium and memantine do not inhibit nociceptive neuronal activity in the trigeminocervical complex of the rat

Experimental studies with NMDA receptor antagonists, such as magnesium and memantine, have demonstrated the ability of these substances to inhibit nociceptive trigeminal neurotransmission in electrophysiological studies. Despite these promising experimental results clinical trials results have been less than clear. To investigate further this contrast using the open channel blockers, magnesium and memantine, we studied their effects in a model of nociceptive trigeminovascular activation.

• Publication year

  2013

• Venue

  The Journal of Headache and Pain

• Publication date

  2013-02-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1129-2377-14-S1-P71PMCID 3620493
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Prophylaxis of Migraine with Oral Magnesium: Results From A Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study

  1996cited by this paper
• [N-methyl-D-aspartate receptor channel complex].

  1989cited by this paper

• Glutamate and Its Receptors as Therapeutic Targets for Migraine

  2018cites this paper
• Nutraceutical and Other Modalities for the Treatment of Headache

  2015cites this paper