Circumscribed Choroidal Hemangioma

Circumscribed choroidal hemangiomas are benign vascular hamartomas without systemic associations. Generally, they are orange-red elevated masses, which are found posterior to the equator. Lesions are usually solitary and unilateral. Overlying subretinal fluid, serous retinal detachment and cystoid macular edema are common findings. Intravenous fluorescein angiography, indocyanine green angiography, ultrasonography, optical coherence tomography and enhanced depth imaging are helpful ancillary tests for diagnosis of circumscribed choroidal hemangiomas. Asymptomatic circumscribed choroidal hemangiomas do not require treatment. For symptomatic lesions with exudative retinal detachment or cystoid macular edema, photodynamic therapy has emerged as the treatment of choice with high rates of tumor regression, subretinal fluid resorption and minimal complications. Lens-sparing external beam radiotherapy, plaque brachytherapy, proton beam therapy, stereotactic radiosurgery, transpupillary thermotherapy, laser photocoagulation and anti-VEGF injections are other treatment modalities.

• Publication year

  2015

• Venue

  Journal of Ophthalmic & Vision Research

• Publication date

  2015-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4103/2008-322X.170353PMID 26730320PMCID 4687268
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intraocular Tumors: An Atlas and Textbook

  2015cited by this paper
• Oral Propranolol for Circumscribed Choroidal Hemangioma

  2011cited by this paper
• Gamma knife radiosurgery for choroidal hemangioma.

  2011cited by this paper
• Optical coherence tomography enhanced depth imaging of choroidal tumors.

  2011cited by this paper
• Photodynamic therapy of choroidal hemangioma in sturge-weber syndrome, with a review of treatments for diffuse and circumscribed choroidal hemangiomas.

  2011cited by this paper
• Photodynamic therapy for symptomatic circumscribed macular choroidal hemangioma in Chinese patients.

  2010cited by this paper
• Enhanced depth imaging spectral-domain optical coherence tomography.

  2010cited by this paper
• Photodynamic therapy with verteporfin for symptomatic circumscribed choroidal hemangioma: five-year outcomes.

  2010cited by this paper
• Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma.

  2009cited by this paper
• LONG-TERM RESULTS OF LOW-DOSE PROTON BEAM THERAPY FOR CIRCUMSCRIBED CHOROIDAL HEMANGIOMAS

  2009cited by this paper
• Gamma knife radiosurgery for choroidal haemangiomas with extensive exudative retinal detachment

  2009cited by this paper
• Polypoidal Choroidal Vasculopathy following Photodynamic Therapy for Choroidal Hemangioma

  2009cited by this paper
• High-dose iodine-125 episcleral brachytherapy for circumscribed choroidal haemangioma

  2009cited by this paper
• Application of Intravitreal Bevacizumab for Circumscribed Choroidal Hemangioma

  2009cited by this paper
• AUTOFLUORESCENCE OF CHOROIDAL HEMANGIOMA IN 34 CONSECUTIVE EYES

  2009cited by this paper
• FUNDUS AUTOFLUORESCENCE IMAGING: Review and Perspectives

  2008cited by this paper
• Enhanced depth imaging spectral-domain optical coherence tomography.

  2008cited by this paper
• [Photodynamic therapy for circumscribed choroidal hemangioma].

  2007cited by this paper
• Gamma knife radiosurgery for choroidal hemangioma.

  2007cited by this paper
• Blackening of choroidal hemangioma after tantalum clip surgery.

  2007cited by this paper
• Transpupillary thermotherapy for large-sized subfoveal circumscribed choroidal hemangioma.

  2006cited by this paper
• Neovascular growth following photodynamic therapy for choroidal hemangioma and neovascular regression after intravitreous injection of triamcinolone.

  2006cited by this paper
• Blackening of a Choroidal Hemangioma after Photodynamic Therapy

  2005cited by this paper
• Resolution of advanced cystoid macular edema following photodynamic therapy for choroidal hemangioma.

  2005cited by this paper
• The HIF-2alpha/VEGF pathway activation in cutaneous capillary haemangiomas.

  2005cited by this paper
• Review of optical coherence tomography for intraocular tumors

  2005cited by this paper
• Choroidal hemangioma.

  2005cited by this paper
• The role of photodynamic therapy in the treatment of symptomatic choroidal hemangioma

  2005cited by this paper
• Low-dose proton beam therapy for circumscribed choroidal hemangiomas.

  2004influential reference
• Photodynamic therapy of circumscribed choroidal haemangioma

  2004cited by this paper
• Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma.

  2004cited by this paper
• Palladium 103 (103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment.

  2004cited by this paper
• Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma

  2003cited by this paper
• Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapy

  2003cited by this paper
• Photodynamic therapy of circumscribed choroidal hemangioma.

  2003cited by this paper
• Beta blockade induces apoptosis in cultured capillary endothelial cells

  2002cited by this paper
• Photodynamic therapy for circumscribed choroidal haemangioma.

  2002cited by this paper
• Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations.

  2002cited by this paper
• Choroidal hemangiomas with exudative retinal detachments during pregnancy.

  2002cited by this paper
• PRIMARY TRANSPUPILLARY THERMOTHERAPY FOR SMALL CHOROIDAL MELANOMA IN 256 CONSECUTIVE CASES: OUTCOMES AND LIMITATIONS

  2002cited by this paper
• Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases.

  2001influential reference
• External beam irradiation therapy for choroidal haemangiomas. Visual and anatomical results after a dose of 20 to 25 Gy.

  2001influential reference
• Plaque radiotherapy for choroidal hemangioma with total retinal detachment and iris neovascularization.

  2001cited by this paper
• Circumscribed choroidal hemangioma: characteristic features with indocyanine green videoangiography.

  2000cited by this paper
• Indocyanine Green Angiographic Findings in Choroidal Hemangiomas: A Study of 75 Cases

  2000cited by this paper
• Indocyanine green enhanced transpupillary thermotherapy of circumscribed choroidal haemangioma

  2000cited by this paper
• Photodynamic therapy of choroidal hemangioma: two case reports

  2000cited by this paper
• Transpupillary thermotherapy for circumscribed choroidal hemangiomas.

  2000cited by this paper
• Circumscribed choroidal haemangioma in a patient with Sturge Weber syndrome

  2000cited by this paper
• Diffuse and circumscribed choroidal hemangiomas in a patient with Sturge-Weber syndrome.

  1999cited by this paper
• Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma.

  1999influential reference
• Choroidal hemangioma: MR findings and differentiation from uveal melanoma.

  1998cited by this paper
• Proton beam irradiation of choroidal hemangiomas.

  1998cited by this paper
• Choroidal hemangiomas: visual and anatomic results of treatment by photocoagulation or radiation therapy.

  1997cited by this paper
• Long term results after low dose ocular irradiation for choroidal haemangiomas

  1997cited by this paper
• Cobalt-60 treatment of choroidal hemangiomas.

  1996cited by this paper
• Circumscribed choroidal hemangioma.

  1995cited by this paper
• Patterns of indocyanine green videoangiography of choroidal tumours.

  1995cited by this paper
• Diode laser photocoagulation of choroidal hemangioma

  1995cited by this paper
• Vascular targeting in photodynamic occlusion of subretinal vessels.

  1994cited by this paper
• CASE REPORT: ASSOCIATED RETINAL NEOVASCULARIZATION AND CHOROIDAL HEMANGIOMA

  1993cited by this paper
• Choroidal neovascularization associated with choroidal hemangiomas.

  1992cited by this paper
• Progressive enlargement of a circumscribed choroidal hemangioma. A clinicopathologic correlation.

  1992cited by this paper
• ENLARGEMENT OF CIRCUMSCRIBED CHOROIDAL HEMANGIOMAS

  1991cited by this paper
• Circumscribed choroidal hemangiomas.

  1989cited by this paper
• Intraocular tumors: evaluation with MR imaging.

  1988cited by this paper
• [Hemangioma of the choroid].

  1987cited by this paper
• Cavernous hemangioma of the choroid. Clinical review of 10 cases.

  1981cited by this paper
• Spontaneous regression of a choroidal hemangioma following pregnancy.

  1979cited by this paper
• Tumors of the eye

  1977cited by this paper
• Clinical experience with presumed hemangioma of the choroid: radioactive phosphorus uptake studies as an aid in differential diagnosis.

  1976cited by this paper
• Lipofuscin pigment over benign and malignant choroidal tumors.

  1976cited by this paper
• Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature.

  1976influential reference
• Lesions simulating malignant melanoma of the posterior uvea.

  1973cited by this paper
• Visual field studies of benign choroidal melanomata.

  1969cited by this paper
• Fluorescein angiography and hemangiomas of the choroid.

  1967cited by this paper
• [On the differential diagnosis of intraocular tumors].

  1965cited by this paper
• LESIONS MISTAKEN FOR MALIGNANT MELANOMA OF THE POSTERIOR UVEA. A CLINICOPATHOLOGIC ANALYSIS OF 100 CASES WITH OPHTHALMOSCOPICALLY VISIBLE LESIONS.

  1964cited by this paper
• CHOROIDAL HEMANGIOMA.

  1964cited by this paper
• Hemangioma of the choroid.

  1960cited by this paper
• Hemangioma of the choroid: a clinicopathologic analysis.

  1959cited by this paper
• Intraocular tumors. I. Bilateral hemangioma of the choroid.

  1958cited by this paper
• Diseases of the uveal tract.

  1953cited by this paper
• Hemangioma of the choroid.

  1950cited by this paper
• Ophthalmology

  1859cited by this paper

• Beyond Treatment: The Strategy of Nonintervention in Choroidal Hemangioma

  2026cites this paper
• Rare presentation of unilateral multifocal circumscribed choroidal haemangiomas.

  2025cites this paper
• Predicting the therapeutic effect of photodynamic therapy on circumscribed choroidal haemangioma: a retrospective cohort study

  2025cites this paper
• Treatment of Choroidal Metastasis with Combined Photodynamic Therapy and Bevacizumab and Comparison with Photodynamic Therapy Alone.

  2025cites this paper
• Choroidal hypopigmented lesions: A review.

  2025cites this paper
• Clinical trials update in the photodynamic therapy strategy for treatment of choroidal melanoma: a review of literature.

  2025cites this paper
• The Potential Role of Hyperspectral Retinal Imaging of Choroidal Tumors

  2025cites this paper
• Human perception of ionizing radiation.

  2025cites this paper
• Pediatric orbital lesions: ocular pathologies

  2024cites this paper
• Comparison of the therapeutic effects of photodynamic therapy, transpupillary thermotherapy, and their combination on circumscribed choroidal haemangioma.

  2024cites this paper
• Recent Advances in Photodynamic Therapy for Vascular Abnormalities

  2024cites this paper
• [Circumscribed choroidal hemangioma and non-pigmented choroidal melanoma: clinical, instrumental and molecular genetic features].

  2024cites this paper
• A Case of Circumscribed Choroidal Hemangioma Treated With Proton Beam Therapy and Followed Up for 15 Years

  2024cites this paper
• Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study

  2023cites this paper
• Actualización en el diagnóstico y tratamiento del hemangioma coroideo

  2023cites this paper
• β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding

  2023cites this paper
• PHOTODYNAMIC THERAPY-INDUCED ACUTE EXUDATIVE MACULOPATHY IN A CASE SERIES OF CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

  2023cites this paper
• Managing extramacular circumscribed choroidal hemangioma with green laser and anti-vascular endothelial growth factor injection in times of the unavailability of photodynamic therapy

  2023cites this paper
• New insights on circumscribed choroidal hemangioma: “bench to bedside”

  2023cites this paper
• Subretinal autofluorescent deposits: A review and proposal for clinical classification.

  2023cites this paper
• Optical Coherence Tomography in Inflammatory and Neoplastic Lesions Deforming the Choroidal Profile

  2023influential citation
• Comparative analysis of ultrasonic elastosonography and contrast-enhanced ultrasonography in the diagnosis of benign and malignant intraocular tumors

  2023cites this paper
• STELLATE MULTIFORM AMELANOTIC CHOROIDOPATHY

  2023cites this paper
• Occurrence of circumscribed choroidal hemangioma accompanied by polypoidal choroidal vasculopathy and branch retinal vein occlusion: a case report

  2023cites this paper
• Update on the diagnosis and treatment of choroidal hemangioma.

  2023cites this paper
• A Masquerade Case: Choroidal Hemangioma Misdiagnosed As Central Serous Retinopathy

  2023cites this paper
• Profile of patients treated with intravitreal antiangiogenics in a Brazilian public service with high level of complexity

  2023cites this paper
• Clinical impact of the worldwide shortage of verteporfin (Visudyne®) on ophthalmic care

  2022cites this paper
• Half-fluence photodynamic therapy in peripapillary circumscribed choroidal haemangiomas

  2022cites this paper
• ATRX status in patients with gliomas: Radiomics analysis

  2022cites this paper
• Photodynamic therapy in the treatment of circumscribed choroidal hemangioma: Current perspectives.

  2022cites this paper
• Treatment of choroidal hemangioma with photodynamic therapy and bevacizumab.

  2022cites this paper
• Choroidal Hemangioma Associated with Hepatic Hemangioma: A Case Report and Literature Review

  2021cites this paper
• Diagnosis of Choroidal Melanoma

  2021cites this paper
• Retinal Detachment in a 40-Year-Old Man With Sturge-Weber Syndrome.

  2021cites this paper
• Circumscribed Choroidal Hemangioma: Comparative Efficacy of Transpupillary Thermotherapy, Indocyanine Green-Enhanced Transpupillary Thermotherapy, and Photodynamic Therapy and Baseline Clinical Features Affecting Treatment Outcomes.

  2021cites this paper
• Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report

  2021cites this paper
• Choroidal Hemangiomas

  2021cites this paper
• Value of MR-based radiomics in differentiating uveal melanoma from other intraocular masses in adults.

  2020cites this paper
• Photodynamic Therapy (PDT) for Circumscribed Choroidal Hemangioma in 79 Consecutive Patients: Comparative Analysis of Factors Predictive of Visual Outcome.

  2020cites this paper
• High-dose ruthenium-106 plaque therapy for circumscribed choroidal hemangioma: a retrospective study of 25 Chinese patients.

  2020cites this paper
• Ocular manifestations in phakomatosis pigmentovascularis: current concepts on pathogenesis, diagnosis, and management.

  2020cites this paper
• SUBFOVEAL CHOROIDAL THICKNESS AND VASCULAR ARCHITECTURE IN FELLOW EYES OF PATIENTS WITH CIRCUMSCRIBED CHOROIDAL HEMANGIOMA.

  2020cites this paper
• Multifocal circumscribed choroidal hemangioma: a rare occurrence

  2020cites this paper
• Effectiveness and Safety of Intravitreal Injection of Conbercept as an Initial Treatment for Exudative Circumscribed Choroidal Hemangioma

  2020cites this paper
• Successful treatment of an exudative choroidal hemangioma with oral propranolol in a 10-year-old boy.

  2019cites this paper
• Intraretinal haemorrhagic cyst mimicking choroidal haemangioma

  2019cites this paper
• Choroidal Hemangioma and Its Management

  2019cites this paper
• Understanding the structural changes following photodynamic and transpupillary thermotherapy for choroidal hemangioma using optical coherence tomography and optical coherence tomography angiography

  2019cites this paper
• Gamma knife radiosurgery for choroidal hemangioma; a single-institute series.

  2019cites this paper
• Circumscribed choroidal hemangioma: Clinical features and outcomes by age category in 458 cases

  2019cites this paper
• Management of Choroidal Hemangioma

  2019cites this paper
• Choroidal Hemangioma

  2019cites this paper
• Application of ICG-enhanced thermocoagulation method and photodynamic therapy in circumscribed choroidal hemangioma

  2018cites this paper
• Elevated Choroidal Thickness and Central Serous Chorioretinopathy in the Fellow Eyes of Patients with Circumscribed Choroidal Hemangioma

  2018cites this paper
• Retinal fluid changes and therapeutic effects in symptomatic circumscribed choroidal hemangioma patients: a long-term follow up study

  2018cites this paper
• Partial thickness sclerectomy to treat exudative retinal detachment secondary a submacular choroidal hemangioma in a Sturge–Weber syndrome

  2018cites this paper
• Photodynamic therapy for symptomatic circumscribed choroidal hemangioma in 22 Chinese patients: A retrospective study.

  2018cites this paper
• Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma.

  2018cites this paper
• Hemangioma coroideo y terapia fotodinámica. Respuesta anatómica y funcional de los pacientes con hemangioma coroideo tratados con terapia fotodinámica

  2017cites this paper
• Choroidal haemangioma and photodynamic therapy. Anatomical and functional response of patients with choroidal hemangioma treated with photodynamic therapy.

  2017cites this paper
• Unklare seröse Netzhautabhebung

  2017influential citation
• Blood flow pattern in a choroidal hemangioma imaged on swept-source-optical coherence tomography angiography

  2017cites this paper
• RUTHENIUM-106 BRACHYTHERAPY IN THE TREATMENT OF CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

  2017cites this paper
• Case Series of Anti-Vascular Endothelial Growth Factor and Photodynamic Therapy in the Treatment of Circumscribed Choroidal Hemangiomas

  2017influential citation
• TREATMENT OF EXUDATIVE CIRCUMSCRIBED CHOROIDAL HEMANGIOMA: Efficacy of Fractionated Proton Therapy (20 Gray Relative Biological Effectiveness in 8 Fractions)

  2017cites this paper
• INFRARED IMAGING OF CIRCUMSCRIBED CHOROIDAL HEMANGIOMAS

  2017cites this paper
• Treatment Outcome of Serous Macular Detachment in Circumscribed Choroidal Hemangioma

  2017cites this paper
• [Unclear serous retinal detachment].

  2017cites this paper
• Estudi pilot sobre aplicacions de la tomografia de coherència òptica Swept Source en els tumors coroideus

  2015cites this paper
• The Current Management of Choroidal Hemangioma

  year unknowncites this paper