Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2003-12-18

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jm030246pPMID 14667215
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclic hexapeptides related to somatostatin. Conformational analysis employing 1H-NMR and molecular dynamics.

  2009cited by this paper
• Cyclic hexapeptide analogs of somatostatin containing bridge modifications. Syntheses and conformational analyses.

  2009cited by this paper
• Peptide conformation. 48. Conformation and biological activity of proline containing cyclic retro-analogues of somatostatin.

  2009cited by this paper
• SMS 201-995, a very potent analogue of somatostatin. Assignment of the 1H 500 MHz n.m.r. spectra and conformational analysis in aqueous solution.

  2009cited by this paper
• Conformational study of a series of somatostatin analogues with antitumor and/or GH inhibitory activity.

  2009cited by this paper
• Peptide conformations--49(1): synthesis and structure-activity relationships of side chain modified peptides of cyclo(-D-Pro-Phe-Thr-Lys-Trp-Phe.).

  2009cited by this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.

  2003cited by this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.

  2003cited by this paper
• Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents.

  2003cited by this paper
• A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.

  2003cited by this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.

  2003cited by this paper
• A bicyclic and hsst2 selective somatostatin analogue: design, synthesis, conformational analysis and binding.

  2001cited by this paper
• A bioactive somatostatin analog without a type II' beta-turn: synthesis and conformational analysis in solution.

  2001cited by this paper
• Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn.

  2001cited by this paper
• Conformational analyses of sandostatin analogs containing stereochemical changes in positions 6 or 8.

  2000cited by this paper
• Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling.

  2000cited by this paper
• Conformational analyses of cyclic hexapeptide analogs of somatostatin containing arylalkyl peptoid and naphthylalanine residues

  1999cited by this paper
• Conformational analyses by 1H NMR and computer simulations of cyclic hexapeptides related to somatostatin containing acidic and basic peptoid residues.

  1999cited by this paper
• A backbone-cyclic, receptor 5-selective somatostatin analogue: synthesis, bioactivity, and nuclear magnetic resonance conformational analysis.

  1998cited by this paper
• Conformational analyses of somatostatin-related cyclic hexapeptides containing peptoid residues.

  1998cited by this paper
• Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.

  1998cited by this paper
• Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

  1998cited by this paper
• Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures.

  1997cited by this paper
• Torsion angle dynamics for NMR structure calculation with the new program DYANA.

  1997cited by this paper
• A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs.

  1997cited by this paper
• Solution conformation by NMR and molecular modeling of three sulfide-free somatostatin octapeptide analogs compared to angiopeptin

  1996cited by this paper
• Structure of octreotide, a somatostatin analogue.

  1995cited by this paper
• Dynamics and conformational energetics of a peptide hormone: vasopressin.

  1985cited by this paper
• Somatostatin (second of two parts).

  1983cited by this paper
• Effects of somatostatin on mammalian cortical neurons in culture: physiological actions and unusual dose response characteristics

  1983cited by this paper
• In vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat.

  1983cited by this paper
• Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.

  1983cited by this paper
• Nonopioid neuropeptides in mammalian CNS.

  1983cited by this paper
• Somatostatin.

  1983cited by this paper
• A potent cyclic hexapeptide analogue of somatostatin

  1981cited by this paper
• Biologic and immunologic activities and applications of somatostatin analogs.

  1978cited by this paper

• Structural insights into ligand recognition and selectivity of somatostatin receptors

  2022cites this paper
• The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors

  2021cites this paper
• Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

  2021cites this paper
• The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain

  2018cites this paper
• Synthesis on the solid phase of a bioactive tryptathionine octreotate

  2017cites this paper
• Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′,5′difluorophenyl)-alanine

  2016cites this paper
• The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior.

  2015cites this paper
• The production of recombinant (15)N, (13)C-labelled somatostatin 14 for NMR spectroscopy.

  2014cites this paper
• Central Control of Fluid and Electrolyte Homeostasis Brain somatostatin receptor 2 mediates the dipsogenic effect of central somatostatin and cortistatin in rats: role in drinking behavior

  2014cites this paper
• Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine

  2013cites this paper
• Inhibition of the function of TRPV1-expressing nociceptive sensory neurons by somatostatin 4 receptor agonism: mechanism and therapeutical implications.

  2011cites this paper
• N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.

  2011cites this paper
• Improvement of drug-like properties of peptides: the somatostatin paradigm

  2010cites this paper
• Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors.

  2010cites this paper
• Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues.

  2009cites this paper
• Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.

  2009cites this paper
• Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.

  2009cites this paper
• Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.

  2008cites this paper
• Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.

  2008cites this paper
• Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.

  2008cites this paper
• Synthesis and biologic activity of conformationally constrained analogs of L-363,301.

  2008cites this paper
• Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide.

  2007cites this paper
• Molecular Modeling Suggests Conformational Scaffolds Specifically Targeting Five Subtypes of Somatostatin Receptors

  2007influential citation
• Somatostatin sst4 ligands: chemistry and pharmacology.

  2007cites this paper
• Conformational analysis of a potent SSTR3‐selective somatostatin analogue by NMR in water solution

  2006cites this paper
• Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

  2005cites this paper
• Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.

  2005cites this paper
• Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.

  2003cites this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.

  2003cites this paper
• Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.

  2003cites this paper