Synthesis and Evaluation of Neuroprotective Selenoflavanones

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

• Publication year

  2015

• Venue

  International Journal of Molecular Sciences

• Publication date

  2015-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3390/ijms161226188PMID 26690420PMCID 4691131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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