Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Human Genetics

• Publication date

  2010-01-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ajhg.2009.12.009PMID 20085713PMCID PMC2801752
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes

  2008cited by this paper
• SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

  2008cited by this paper
• Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

  2008cited by this paper
• Genome-wide Analysis of Histone Lysine Methylation Variations Caused by Diabetic Conditions in Human Monocytes*

  2007cited by this paper
• The Collaborative Study of Obesity and Diabetes in Adults (CODA) project: meta‐analysis design and description of participating studies

  2007cited by this paper
• Genome–wide association studies provide new insights into type 2 diabetes aetiology

  2007cited by this paper
• Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes

  2007cited by this paper
• How do synonymous mutations affect fitness?

  2007cited by this paper
• A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes.

  2007cited by this paper
• Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

  2007cited by this paper
• Polymorphisms in the 3′ UTR in the neurocalcin δ gene affect mRNA stability, and confer susceptibility to diabetic nephropathy

  2007cited by this paper
• The BIGTT Test

  2007cited by this paper
• Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

  2007cited by this paper
• Prevalence of type 2 diabetes mellitus of Chinese populations in Mainland China, Hong Kong, and Taiwan.

  2006cited by this paper
• Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.

  2006cited by this paper
• Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males.

  2006cited by this paper
• Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot

  2004cited by this paper
• Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

  2004cited by this paper
• Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.

  2004cited by this paper
• High‐throughput single nucleotide polymorphism typing by fluorescent single‐strand conformation polymorphism analysis with capillary electrophoresis

  2004cited by this paper
• Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.

  2003cited by this paper
• A Single-nucleotide Deletion Leads to Rapid Degradation ofTAP-1 mRNA in a Melanoma Cell Line*

  2003cited by this paper
• Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.

  2003cited by this paper
• Mfold web server for nucleic acid folding and hybridization prediction

  2003cited by this paper
• Effects of Lifestyle Modifications on Patients with Type 2 Diabetes: The Japan Diabetes Complications Study (JDCS) Study Design, Baseline Analysis and Three Year-Interim Report

  2002cited by this paper
• Relationship between ethnicity and glycemic control, lipid profiles, and blood pressure during the first 9 years of type 2 diabetes: U.K. Prospective Diabetes Study (UKPDS 55).

  2001cited by this paper
• Global and societal implications of the diabetes epidemic

  2001cited by this paper
• The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion.

  2000cited by this paper
• Genomewide search for type 2 diabetes susceptibility genes in four American populations.

  2000cited by this paper
• Expression of the calcium-sensing receptor in pancreatic islet B-cells.

  1999cited by this paper
• Identification of Native Atrial G-protein-regulated Inwardly Rectifying K+ (GIRK4) Channel Homomultimers*

  1998cited by this paper
• Cloning and Characterization of Two K+ Inward Rectifier (Kir) 1.1 Potassium Channel Homologs from Human Kidney (Kir1.2 and Kir1.3)*

  1997cited by this paper
• Diabetes mellitus. Report of a WHO Study Group.

  1985cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Supporting Online Material Materials and Methods Figs. S1 to S8 Tables S1 to S10 References a Genome-wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

  year unknowncited by this paper

• The physiological characteristics of inward rectifying potassium channel Kir4.2 and its research progress in human diseases

  2025cites this paper
• Integrative transcriptomic analysis identifies common biomarkers in type 1 and type 2 diabetes using WGCNA and machine learning

  2025cites this paper
• A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial

  2025cites this paper
• Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function

  2025cites this paper
• Advancing Kir4.2 Channel Ligand Identification through Collision-Induced Affinity Selection Mass Spectrometry

  2024cites this paper
• Comparison of medication persistence and adherence in type 2 diabetes using a once-weekly regimen of DPP-4 inhibitor compared with once-daily and twice-daily regimens: a retrospective cohort study of Japanese health insurance claims data

  2024cites this paper
• Ethnicity‐related differences in mitochondrial regulation by insulin stimulation in diabetes

  2024cites this paper
• A long-term high-fat diet induces differential gene expression changes in spatially distinct adipose tissue of male mice

  2024cites this paper
• Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression

  2024cites this paper
• Nutrigenomics of inward rectifier potassium channels.

  2023cites this paper
• Transcriptome analysis of peripheral blood mononuclear cells in patients with type 1 diabetes mellitus

  2022cites this paper
• Genome-wide DNA methylation profiling in differentiating Crohn’s disease from intestinal tuberculosis

  2022cites this paper
• KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma

  2020cites this paper
• Iterative feature selection method to discover predictive variables and interactions for high-dimensional transplant genomic data

  2019cites this paper
• Genetic Analysis of Spontaneous Preterm Birth

  2019cites this paper
• Loss of KCNJ15 expression promotes malignant phenotypes and correlates with poor prognosis in renal carcinoma

  2019cites this paper
• Hierarchical Assembly of siRNA with Tetraamino Fullerene in Physiological Conditions for Efficient Internalization into Cells and Knockdown.

  2018cites this paper
• Differences in the genetic backgrounds of patients with alcoholic liver disease and non‐alcoholic fatty liver disease

  2018cites this paper
• Daily walking is effective for the management of pregnant women with gestational diabetes mellitus

  2018cites this paper
• Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

  2018cites this paper
• Genetics of Diabetes: Are They Thrifty Genotype?

  2017cites this paper
• Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients.

  2017cites this paper
• Aberrant Expression of Long Non-Coding RNAs in Newly Diagnosed Type 2 Diabetes Indicates Potential Roles in Chronic Inflammation and Insulin Resistance

  2017cites this paper
• Potassium Channel Mutations and Human Disease: Focus on Adrenal Hypertension

  2017cites this paper
• Dietary magnesium intake and the risk of diabetes in the Japanese community: results from the Takayama study

  2017cites this paper
• Lean T ype 2 D iabetes Mellitus

  2016cites this paper
• Association of the Single Nucleotide Polymorphisms in RUNX1, DYRK1A, and KCNJ15 with Blood Related Traits in Pigs

  2016cites this paper
• The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus

  2016influential citation
• Daily walking decreases casual glucose level among pregnant women in the second trimester.

  2016cites this paper
• MYH9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes.

  2015cites this paper
• Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion.

  2015cites this paper
• Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

  2015cites this paper
• Identification of Genomic Regions and the Isoamylase Gene for Reduced Grain Chalkiness in Rice

  2015cites this paper
• First Genome-Wide Association Study in an Australian Aboriginal Population Provides Insights into Genetic Risk Factors for Body Mass Index and Type 2 Diabetes

  2015cites this paper
• Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.

  2015cites this paper
• Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women

  2015cites this paper
• Do body mass index trajectories affect the risk of type 2 diabetes? A case–control study

  2015cites this paper
• Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue

  2015cites this paper
• Potassium channel KCNJ 15 is required for histamine-stimulated gastric acid secretion

  2015cites this paper
• Effect of body mass index on insulin secretion or sensitivity and diabetes.

  2015cites this paper
• MYH 9 gene polymorphisms may be associated with cerebrovascular blood flow in patients with type 2 diabetes

  2015influential citation
• Exploring the Molecular Basis of Lean Diabetes

  2015cites this paper
• TEN The Calcium-Sensing Receptor and b-Cell Function

  2014cites this paper
• Potassium Channels: Structures, Diseases, and Modulators

  2014cites this paper
• Serum Triglyceride Levels Correlated with the Rate of Change in Insulin Secretion Over Two Years in Prediabetic Subjects

  2014cites this paper
• The calcium-sensing receptor and β-cell function.

  2014cites this paper
• Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population

  2013cites this paper
• Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes

  2013cites this paper
• Age differences in the risk of diabetes incidence according to body mass index level in Japanese women.

  2013cites this paper
• Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study

  2013cites this paper
• Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women

  2013cites this paper
• Ion channels and regulation of insulin secretion in human β-cells

  2013cites this paper
• U-shaped relationship between body mass index and incidence of diabetes

  2012cites this paper
• Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis.

  2012influential citation
• Influence of age on the association of GIRK4 with metabolic syndrome

  2012cites this paper
• Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes

  2012cites this paper
• Inherited β-Cell Dysfunction in Lean Individuals With Type 2 Diabetes

  2012cites this paper
• Introduction of glycated albumin measurement for all blood donors and the prevalence of a high glycated albumin level in Japan

  2012cites this paper
• Determination of the Function of a Mutation

  2012cites this paper
• Randomized Controlled Trial of the Effectiveness of Genetic Counseling and a Distance, Computer-Based, Lifestyle Intervention Program for Adult Offspring of Patients with Type 2 Diabetes: Background, Study Protocol, and Baseline Patient Characteristics

  2012cites this paper
• Common variation in GPC5 is associated with acquired nephrotic syndrome

  2011cites this paper
• Genetic bases for glaucoma.

  2010cites this paper