MAPK-Activated Protein Kinase 2 Contributes to Clostridium difficile-Associated Inflammation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Infection and Immunity

• Publication date

  2012-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00186-12PMID 23264053PMCID PMC3584893
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Fidaxomicin versus vancomycin for Clostridium difficile infection.

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• Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

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• The MAP kinase‐activated protein kinase 2 (MK2) contributes to the Shiga toxin‐induced inflammatory response

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• Diarrhea, clostridium difficile, and intestinal inflammation in residents of a long-term care facility.

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• Proinflammatory fecal mRNA and childhood bacterial enteric infections

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  2009cited by this paper
• Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A*

  2009cited by this paper
• Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology.

  2009cited by this paper
• Toxin B is essential for virulence of Clostridium difficile

  2009cited by this paper
• Structural Analysis of Carboline Derivatives As Inhibitors of MAPKAP K2 Using 3D QSAR and Docking Studies

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.

  2009cited by this paper
• The p38alpha kinase plays a central role in inflammation.

  2009cited by this paper
• Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27.

  2008cited by this paper
• The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• MK2 and MK3--a pair of isoenzymes?

  2008cited by this paper
• A mouse model of Clostridium difficile-associated disease.

  2008cited by this paper
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  2008cited by this paper
• Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

  2008cited by this paper
• Strategies to Prevent Clostridium difficile Infections in Acute Care Hospitals

  2008cited by this paper
• Protein kinases as small molecule inhibitor targets in inflammation.

  2007cited by this paper
• Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors.

  2007cited by this paper
• Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

  2007influential reference
• Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile-associated diarrhea.

  2007cited by this paper
• Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A

  2007cited by this paper
• MAPK-activated Protein Kinase-2 (MK2)-mediated Formation and Phosphorylation-regulated Dissociation of the Signal Complex Consisting of p38, MK2, Akt, and Hsp27*

  2006cited by this paper
• Epidemic Clostridium difficile.

  2006cited by this paper
• The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

  2006cited by this paper
• Epidemic Clostridium difficile.

  2006cited by this paper
• MAPKAP kinases — MKs — two's company, three's a crowd

  2006cited by this paper
• A Common Polymorphism in the Interleukin 8 Gene Promoter Is Associated with Clostridium difficile Diarrhea

  2006cited by this paper
• Structural basis for the function of Clostridium difficile toxin B.

  2005cited by this paper
• Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.

  2005cited by this paper
• Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole.

  2005cited by this paper
• A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality.

  2005cited by this paper
• Alternative treatments for Clostridium difficile disease: what really works?

  2005cited by this paper
• Clostridium difficile Toxin A Induces Expression of the Stress-induced Early Gene Product RhoB*

  2005cited by this paper
• Long-Term Exposure of the HT-29 Human Intestinal Epithelial Cell Line to TNF Causes Sustained Up-Regulation of the Polymeric Ig Receptor and Proinflammatory Genes through Transcriptional and Posttranscriptional Mechanisms1

  2005cited by this paper
• Clostridium difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E2 Synthesis in Colonocytes via Reactive Oxygen Species and Activation of p38 MAPK*

  2005cited by this paper
• Clostridium difficile Toxins: Mechanism of Action and Role in Disease

  2005cited by this paper
• Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin‐8 secretion

  2005cited by this paper
• Essential Involvement of IFN-γ in Clostridium difficile Toxin A-Induced Enteritis1

  2004cited by this paper
• Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001.

  2004cited by this paper
• Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

  2003cited by this paper
• Faecal lactoferrin assay as an adjunct to Clostridium difficile diarrhoea.

  2002cited by this paper
• Distinct Cellular Functions of MK2

  2002cited by this paper
• Infection of hamsters with epidemiologically important strains of Clostridium difficile.

  2001cited by this paper
• Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats.

  2001cited by this paper
• p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis.

  2000cited by this paper
• Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells.

  2000cited by this paper
• Clostridium difficile toxin and faecal lactoferrin assays in adult patients.

  2000cited by this paper
• The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism

  1999cited by this paper
• Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis

  1997cited by this paper
• Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes

  1997cited by this paper
• Comparison of cycloserine-cefoxitin-fructose agar (CCFA) and taurocholate-CCFA for recovery of Clostridium difficile during surveillance of hospitalized patients.

  1997cited by this paper
• A rapid test for infectious and inflammatory enteritis.

  1994cited by this paper
• Clostridium difficile infection in adult hamsters.

  1991cited by this paper
• Clostridium difficile typhlitis associated with cecal mucosal hyperplasia in Syrian hamsters.

  1991cited by this paper
• Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis.

  1980cited by this paper
• Oral vancomycin for antibiotic-associated pseudomembranous colitis.

  1978cited by this paper

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  2021cites this paper
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  2021cites this paper
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• The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse

  2020cites this paper
• Fecal host biomarkers predicting severity of Clostridioides difficile infection.

  2020cites this paper
• The Inflammasome and Type-2 Immunity in Clostridium difficile Infection

  2020cites this paper
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  2019cites this paper
• Probing Clostridium difficile Infection in Complex Human Gut Cellular Models

  2019cites this paper
• A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector

  2018cites this paper
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  2018cites this paper
• Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Clostridium difficile and Clostridium sordellii toxins, proinflammatory versus anti-inflammatory response.

  2017cites this paper
• The role of toxins in Clostridium difficile infection.

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• Biomarkers of Gastrointestinal Host Responses to Microbial Infections

  2016cites this paper
• The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

  2016cites this paper
• Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.

  2016cites this paper
• Host response to Clostridium difficile infection: Diagnostics and detection.

  2016cites this paper
• Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen interactions in a vertical diffusion chamber.

  2016cites this paper
• Immune responses induced by Clostridium difficile.

  2016cites this paper
• Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections

  2015cites this paper
• The molecular basis of Clostridium difficile disease and host response

  2015cites this paper
• Preface: Clostridium difficile Infection.

  2015cites this paper
• Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease

  2015cites this paper
• Human neutrophils are activated by a peptide fragment of Clostridium difficile toxin B presumably via formyl peptide receptor

  2015cites this paper
• Controversies Surrounding Clostridium difficile Infection in Infants and Young Children

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• Utility of Clostridium difficile Toxin B for Inducing Anti-Tumor Immunity

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• Pleiotropic Effects of Blastocystis spp. Subtypes 4 and 7 on Ligand-Specific Toll-Like Receptor Signaling and NF-κB Activation in a Human Monocyte Cell Line

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• Host recognition of Clostridium difficile and the innate immune response.

  2014cites this paper
• Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

  2014cites this paper
• Intestinal inflammatory biomarkers and outcome in pediatric Clostridium difficile infections.

  2013cites this paper
• What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition

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