Relationship between platelet activating factor acetylhydrolase activity and apolipoprotein B levels in patients with peanut allergy

BackgroundPlatelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. PAF acetylhydrolase (PAF-AH) inactivates PAF and protects against severe anaphylaxis whereas deficiency of PAF-AH predisposes to severe or fatal anaphylaxis. Determinants of PAF-AH activity have not been studied in patients with peanut allergy.ObjectivesTo determine whether plasma PAF-AH activity in patients with peanut allergy is related to formation of circulating complexes with apolipoprotein B (apoB) the main surface protein on low density lipoprotein particles.MethodsPlasma PAF-AH activity and apoB concentrations were measured in 63 peanut allergic patients (35 boys, 28 girls, ages 2 – 19 years). ApoB concentration was measured immunoturbidimetrically using goat anti-human apoB. The correlation between PAF-AH activity and apoB concentration was determined.ResultsA positive correlation was found between PAF-AH activity and apoB concentration (r2 = 0.59, P < 0.0001).ConclusionIn peanut allergic patients, PAF-AH activity strongly correlates with apoB concentration, suggesting the presence of circulating PAF-AH- lipoprotein complexes.

• Publication year

  2014

• Venue

  Allergy, Asthma & Clinical Immunology

• Publication date

  2014-04-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1710-1492-10-20PMID 24808915PMCID 4012516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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