Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

John A. H. Hoerter,J. Brzostek,M. Artyomov,S. Abel,J. Casas,Vasily Rybakin,J. Ampudia,C. Lotz,J. Connolly,A. Chakraborty,K. Gould,N. Gascoigne

Published 2013 in Journal of Experimental Medicine

ABSTRACT

The requirement for the TCR to interact with coagonists, endogenous MHC–peptide complexes which do not themselves activate the T cell, decreases as the strength of the CD8–class I interaction increases.

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