Epigenetics: Its Understanding Is Crucial to a Sustainable Healthcare System

Understanding the molecular impact of lifestyle factors has never been so important; a period in time where there are so many adults above retirement age has been previously unknown. As a species, our life expectancy is increasing yet the period of our lives where we enjoy good health is not expanding proportionately. Over the next 50 years we will need to almost double the percentage of GDP spent on health care, largely due to the increasing incidence of obesity related chronic diseases. A greater understanding and implementation of an integrated approach to health is required. Research exploring the impact of nutritional and exercise intervention on the epigenetically flexible genome is up front in terms of addressing healthy aging. Alongside this, we need a greater understanding of the interaction with our immune and nervous systems in preserving and maintaining health and cognition.

• Publication year

  2015

• Venue

  Healthcare

• Publication date

  2015-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.3390/healthcare3020194PMID 27417756PMCID 4939546
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dynamic epigenetic responses to muscle contraction.

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• Physical Exercise and Epigenetic Modulation: Elucidating Intricate Mechanisms

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• Epigenetics in adaptive evolution and development

  2013cited by this paper
• Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity

  2013influential reference
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• A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

  2013influential reference
• Exercise training attenuates adipose tissue fibrosis in diet-induced obese mice.

  2013cited by this paper
• Nutrigenetics, Nutrigenomics, and the Future of Dietary Advice

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• Acute exercise remodels promoter methylation in human skeletal muscle.

  2012cited by this paper
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  2010cited by this paper
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  1993cited by this paper
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  1992cited by this paper

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