The Effect of Methylphenidate and Aerobic Exercise on Renal Function of Male Rats

Introduction: Inadequate awareness and knowledge exists regarding the effects of stimulant drugs on renal health among athletes. The present study aimed to determine the effects of methylphenidate, as a stimulant drug, and aerobic exercise on renal function in rats. Materials and Methods: Eighty male rats were randomly divided into 8 groups (n=10 per group) including control (Co), aerobic exercise sham (AE Sh), drug sham (D Sh), aerobic exercise (AE), the effective dose of drug (ED, 10 mg/kg), 3 times of effective dose (TED, 30 mg/kg), aerobic exercise-effective dose (AE-ED), and aerobic exercise-three times of effective dose (AE-TED). The drug was orally administrated to the animals, and then they were placed on a rat treadmill after 30 minutes. The physical activity (25 m/min) was performed 30 minutes a day, 3 days a week for two months. Twenty-four hours after the last session of AE, blood samples were taken from the rats and serum creatinine (Cr) and blood urea nitrogen (BUN) were determined. Results: The results showed that serum Cr and BUN levels were not significantly different in the exercise group compared to the control groups (i.e., Co, AE Sham, and D Sham). However, serum BUN and Cr significantly increased in the AE-ED and AE-TED groups compared to the AE group (PCr=0.001 and PBUN=0.001). Conclusion: In general, significant increases in the serum BUN and Cr levels in rats received methylphenidate indicated decreased renal function in these animals.

• Publication year

  2019

• Venue

  International Journal of Basic Science in Medicine

• Publication date

  2019-03-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.15171/IJBSM.2019.03
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Basic & Clinical Pharmacology

  2018cited by this paper
• Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats.

  2018cited by this paper
• “At Such a Good School, Everybody Needs It”: Contested Meanings of Prescription Stimulant Use in College Academics

  2017cited by this paper
• Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.

  2017cited by this paper
• Methylphenidate effects in the young brain: friend or foe?

  2017cited by this paper
• Evidence in anti-doping at the intersection of science and law

  2016cited by this paper
• Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats.

  2016cited by this paper
• The Anti‐Doping Movement

  2016cited by this paper
• Transferring athletes' personal data from the EU to third countries for anti-doping purposes: applying Recital 112 GDPR in the post-Schrems era

  2016cited by this paper
• The Effect of 8 Weeks of Resistance Training on Ovary Morphology, Glycemic control and Body Composition on Women with Polycystic Ovary Syndrome

  2015cited by this paper
• THE EFFECT OF RESISTANCE TRAINING PROGRAMS ON GFR AND SOME BIOCHEMICAL FACTORS OF RENAL FUNCTION IN ELDERLY MALES WITH TYPE 2 DIABETES

  2015cited by this paper
• Study of the safety of methylphenidate: Focus on nephrotoxicity aspects.

  2015cited by this paper
• Brain apoptosis signaling pathways are regulated by methylphenidate treatment in young and adult rats.

  2014cited by this paper
• Time for change: a roadmap to guide the implementation of the World Anti-Doping Code 2015

  2014cited by this paper
• Acute administration of methylphenidate alters the prefrontal cortex neuronal activity in a dose–response characteristic

  2014cited by this paper
• Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors.

  2014cited by this paper
• The Effect of Six Months of Aerobic training on Renal Function Markers in Untrained Middle-Aged Women

  2013cited by this paper
• Comparison the effect of interval, continuous and parallel aerobic exercise on urea, uric acid and creatinine of urine level

  2013cited by this paper
• Methylphenidate induces lipid and protein damage in prefrontal cortex, but not in cerebellum, striatum and hippocampus of juvenile rats

  2012cited by this paper
• The Effect of aerobic training on the Amount of GFR and excreted of Creatinine in Patients with Chronic kidney

  2012cited by this paper
• Apoptosis and acute kidney injury.

  2011cited by this paper
• The effect of graded maximal aerobic exercise on some metabolic hormones, muscle damage and some metabolic end products in sportsmen

  2011cited by this paper
• Are prescription stimulants "smart pills"? The epidemiology and cognitive neuroscience of prescription stimulant use by normal healthy individuals.

  2011cited by this paper
• Effect of exercise training on renal function and renal aquaporin‐2 expression in rats with chronic heart failure

  2011cited by this paper
• Comparing the Effects of Two Training Methods of Aerobic and Anaerobic on some Pre-inflammatory Cytokines in Adult Male Rats

  2009cited by this paper
• Inflammation in Acute Kidney Injury

  2008cited by this paper
• A young man with acute dilated cardiomyopathy associated with methylphenidate

  2008cited by this paper
• Methamphetamine‐Induced Early Increase of IL‐6 and TNF‐α mRNA Expression in the Mouse Brain

  2008cited by this paper
• Prevalence of Doping Agents' Abuse and Male Bodybuilders' Knowledge about their Side Effects in Kermanshah Gymnasiums (2004)

  2008cited by this paper
• Investigate the effect of regular exercise on diabetic nephropathy in rat

  2007cited by this paper
• Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men.

  2006cited by this paper
• Training alterations in elite cyclists may cause transient changes in glomerular filtration rate.

  2004cited by this paper
• Effects Of Exercise On Laboratory Test Results

  2003cited by this paper
• Altered responsiveness to cocaine in rats exposed to methylphenidate during development

  2002cited by this paper
• Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers.

  2002cited by this paper
• Point-of-Care Biochemical Monitoring of Boston Marathon Runners: A Comparison of Prerace and Postrace Controls to Runners Requiring On-site Medical Attention

  2002cited by this paper
• Creatine and creatinine metabolism.

  2000cited by this paper
• Pharmacokinetics and Clinical Effectiveness of Methylphenidate

  1999cited by this paper
• Exercise and Renal Function

  1996cited by this paper
• Oxygen cost of treadmill running in 24-month-old Fischer-344 rats.

  1993cited by this paper
• Exercise training ameliorates progressive renal disease in rats with subtotal nephrectomy.

  1987cited by this paper
• Multiple organ failure resulting from intravenous abuse of methylphenidate hydrochloride.

  1985cited by this paper
• Pharmacokinetics of methylphenidate in man, rat and monkey.

  1983cited by this paper
• Biochemical changes in a 100 km run: Free amino acids, urea, and creatinine

  1979cited by this paper
• Doping of Athletes

  1964cited by this paper

• No citing papers are available for this paper.