Transgenic Expression of the p16INK4a Cyclin-Dependent Kinase Inhibitor Leads to Enhanced Apoptosis and Differentiation Arrest of CD4−CD8− Immature Thymocytes

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Immunology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.168.5.2325PMID 11859122
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells

  2001cited by this paper
• Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

  2001cited by this paper
• Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

  2001cited by this paper
• Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells1

  2001cited by this paper
• Down-Regulation of p27 Expression Is Required for Development and Function of T Cells

  2000cited by this paper
• Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

  2000cited by this paper
• FADD/MORT1 regulates the pre‐TCR checkpoint and can function as a tumour suppressor

  2000cited by this paper
• Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

  1999cited by this paper
• Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.

  1999cited by this paper
• The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

  1999cited by this paper
• Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.

  1999cited by this paper
• The INK4A/ARF locus and its two gene products.

  1999cited by this paper
• The INK4 family of cell cycle inhibitors in cancer

  1999cited by this paper
• Pleiotropic changes controlled by the pre-T-cell receptor.

  1999cited by this paper
• The p16INK4a/CDKN2A tumor suppressor and its relatives.

  1998cited by this paper
• In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development.

  1998cited by this paper
• On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment

  1998cited by this paper
• Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

  1997cited by this paper
• Intrathymic δ Selection Events in γδ Cell Development

  1997cited by this paper
• Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

  1996influential reference
• Role of the INK4a locus in tumor suppression and cell mortality.

  1996cited by this paper
• Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.

  1996cited by this paper
• Growth suppression by p16ink4 requires functional retinoblastoma protein.

  1995cited by this paper
• Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

  1995cited by this paper
• Development and selection of T cells: facts and puzzles.

  1995cited by this paper
• Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.

  1994cited by this paper
• Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

  1994cited by this paper
• CD3ε-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2−/− mice in the absence of TCR β chain expression

  1994influential reference
• A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

  1993cited by this paper
• Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

  1993cited by this paper
• RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.

  1992cited by this paper
• Functional dissection of the lck proximal promoter

  1992cited by this paper

• The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis

  2024cites this paper
• Effects of Epstein-Barr Virus Infection on the Risk and Prognosis of Primary Laryngeal Squamous Cell Carcinoma: A Hospital-Based Case-Control Study in Taiwan

  2021cites this paper
• Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression

  2018cites this paper
• Perspectives for Improvement of the Thymic Microenvironment through Manipulation of Thymic Epithelial Cells: A Mini-Review

  2015cites this paper
• EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by infection

  2013cites this paper
• Induction of p16INK4a Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines

  2013cites this paper
• EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by

  2013cites this paper
• 1 Fibroblast Growth Factor-7 Partially Reverses Murine Thymocyte Progenitor Aging By Repression of Ink 4 a

  2012cites this paper
• Genetic regulation of thymocyte progenitor aging.

  2012cites this paper
• Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.

  2012cites this paper
• Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes.

  2011cites this paper
• The Ets-1 transcription factor controls the development and function of natural regulatory T cells

  2010cites this paper
• Tumor suppressor mechanisms in immune aging.

  2009cites this paper
• Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.

  2009cites this paper
• DNA methylation-independent regulation of p16 in epithelial cells during mouse mammary gland development

  2008cites this paper
• Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

  2008cites this paper
• Rearrangements and amplification of the ABL1 gene as an example of kinase activation in T-cell acute lymphoblastic

  2008cites this paper
• Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo

  2008cites this paper
• p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.

  2007cites this paper
• Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice

  2007cites this paper
• Redox-evolution of Eca-109 cells by 8-Br-cAMP and quercetin and correlation with p16 ssDNA binding nuclear matrix protein

  2007cites this paper
• Regulation of T‐cell progenitor survival and cell‐cycle entry by the pre‐T‐cell receptor

  2006cites this paper
• Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation1

  2006cites this paper
• The tumor suppressor p16Ink4a regulates T lymphocyte survival

  2006cites this paper
• The role of cyclin-dependent kinases in T-cell development, proliferation, and function.

  2006cites this paper
• TLX1/HOX11‐mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double‐positive stage

  2006cites this paper
• Lymphocyte Proliferation T + and Antigen-Experienced CD 8 Distinct Mechanisms Control Human Naive Romero and

  2006cites this paper
• INK4a/ARF: a multifunctional tumor suppressor locus.

  2005cites this paper
• Telomeres, stem cells, senescence, and cancer.

  2004cites this paper
• Ink4a/Arf links senescence and aging.

  2004cites this paper
• p16Ink4a Interferes with Abelson Virus Transformation by Enhancing Apoptosis

  2004cites this paper
• Lentivector-Mediated Transfer of Bmi-1 and Telomerase in Muscle Satellite Cells Yields a Duchenne Myoblast Cell Line with Long-Term Genotypic and Phenotypic Stability

  2003cites this paper
• Cell death in the thymus--it' s all a matter of contacts.

  2003cites this paper