Gastric H+/K(+)-ATPase: targeting signals in the regulation of physiologic function.

The H+/K(+)-ATPase of gastric parietal cells catalyzes acid secretion in the stomach. Regulation of this pump's function involves its targeting to an intracellular storage compartment, which fuses with the apical plasma membrane in response to secretagogue stimulation. The H+/K(+)-ATPase must also be returned to this intracellular storage compartment to inactivate acid secretion. Recent research suggests that a number of targeting signals and protein-protein interactions participate in governing this process.

• Publication year

  1998

• Venue

  Current Opinion in Cell Biology

• Publication date

  1998-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0955-0674(98)80060-4PMID 9719867
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Does the colonic H,K-ATPase also act as an Na,K-ATPase?

  1998cited by this paper
• A basolateral sorting signal is encoded in the alpha-subunit of Na-K-ATPase.

  1998cited by this paper
• Membrane polarity in epithelial cells: protein sorting and establishment of polarized domains.

  1997cited by this paper
• Association of syntaxin 3 and vesicle-associated membrane protein (VAMP) with H+/K(+)-ATPase-containing tubulovesicles in gastric parietal cells.

  1997cited by this paper
• The γ subunit is a specific component of the Na,K‐ATPase and modulates its transport function

  1997cited by this paper
• Structural Aspects of the Gastric H, K ATPase a

  1997cited by this paper
• Subunit Interactions in the Na,K-ATPase Explored with the Yeast Two-hybrid System*

  1997cited by this paper
• A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion.

  1997cited by this paper
• Ezrin is a cyclic AMP‐dependent protein kinase anchoring protein

  1997cited by this paper
• Ion pumps in epithelial cells: sorting, stabilization, and polarity.

  1997cited by this paper
• Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles.

  1997cited by this paper
• Cellular localization and regulation of CHIF in kidney and colon.

  1996cited by this paper
• Functional expression of the cDNA encoded by the human ATP1AL1 gene.

  1996cited by this paper
• Differential regulation of putative K(+)-ATPase by low-K+ diet and corticosteroids in rat distal colon and kidney.

  1996cited by this paper
• Chronic hypokalemia enhances expression of the H(+)-K(+)-ATPase alpha 2-subunit gene in renal medulla.

  1996cited by this paper
• Protein trafficking and polarity in kidney epithelium: from cell biology to physiology.

  1996cited by this paper
• Colocalization of H-ATPase and H,K-ATPase immunoreactivity in the rat kidney.

  1995cited by this paper
• A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.

  1995cited by this paper
• Expression of colonic H-K-ATPase mRNA in cortical collecting duct: regulation by acid/base balance.

  1995cited by this paper
• Expression of gastric and colonic H(+)-K(+)-ATPase in the rat kidney.

  1995cited by this paper
• Regulation of H(+)-K(+)-ATPase expression in kidney.

  1995cited by this paper
• Mat-8, a Novel Phospholemman-like Protein Expressed in Human Breast Tumors, Induces a Chloride Conductance in Xenopus Oocytes (*)

  1995cited by this paper
• Gastric acid secretion.

  1995cited by this paper
• Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells

  1995cited by this paper
• Cloning and characterization of the entire cDNA encoded by ATP1AL1 — a member of the human Na,K/H,K‐ATPase gene family

  1994cited by this paper
• Gastric parietal cell H(+)-K(+)-ATPase microsomes are associated with isoforms of ankyrin and spectrin.

  1993cited by this paper
• Mechanisms of urinary K+ and H+ excretion: primary structure and functional expression of a novel H,K-ATPase

  1993cited by this paper
• An ion-transporting ATPase encodes multiple apical localization signals

  1993cited by this paper
• Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase

  1993cited by this paper
• Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps

  1993cited by this paper
• Ezrin-calpain I interactions in gastric parietal cells.

  1993cited by this paper
• Functional properties of an H,K-ATPase/Na,K-ATPase chimera.

  1993cited by this paper
• Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identification of protein domains that participate in Na,K-ATPase and H,K-ATPase subunit assembly.

  1993cited by this paper
• Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus.

  1992cited by this paper
• Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes.

  1992cited by this paper
• Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.

  1992cited by this paper
• Structure-function relationship of Na,K-ATPase.

  1991cited by this paper
• Mutational analysis of the cytoplasmic tail of the human transferrin receptor. Identification of a sub-domain that is required for rapid endocytosis.

  1991cited by this paper
• The family of human Na,K‐ATPase genesATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase

  1991cited by this paper
• The secretion‐stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli.

  1991cited by this paper
• H-K-ATPase immunoreactivity in cortical and outer medullary collecting duct.

  1990cited by this paper
• The mechanism and structure of the gastric H,K-ATPase.

  1990cited by this paper
• Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis.

  1990cited by this paper
• Polarized sorting in epithelia.

  1990cited by this paper
• A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.

  1990cited by this paper
• Membrane-cytoskeleton dynamics in rat parietal cells: mobilization of actin and spectrin upon stimulation of gastric acid secretion

  1989cited by this paper
• Functional epithelial cells in culture

  1989cited by this paper
• The family of human Na+K+‐ATPase genes

  1987cited by this paper
• Ion motive ATPases. I. Ubiquity, properties, and significance to cell function

  1987cited by this paper
• Monoclonal antibodies against gastric H+ + K+ ATPase.

  1983cited by this paper
• Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase.

  1982cited by this paper
• Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the Na, K-ATPase.

  1978cited by this paper

• Interplay of potassium channel, gastric parietal cell and proton pump in gastrointestinal physiology, pathology and pharmacology.

  2021cites this paper
• Extra-gastric expression of the proton pump H+/K+-ATPase in the gills and kidney of the teleost Oreochromis niloticus

  2020cites this paper
• Effect of the exposure to suspended solids on the enzymatic activity in the bivalve Sinonovacula constricta

  2017cites this paper
• Gastric H+,K+-ATPase

  2008cites this paper
• Molecular Biology of Renal Acid–Base Transporters

  2005cites this paper
• Regulation of protein and vesicle trafficking at the apical membrane of epithelial cells.

  2002cites this paper
• Mechanisms through which ammonia regulates cortical collecting duct net proton secretion.

  2002cites this paper
• ATPase pumps in osteoclasts and osteoblasts.

  2002cites this paper
• Molecular determinants for apical expression of the renal type IIa Na+/Pi-cotransporter

  2001cites this paper
• Interaction of α- and β-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase β-subunit

  2000cites this paper
• Expression of a duplicate Na,K-ATPase beta(1)-isoform in the European eel (Anguilla anguilla).

  2000cites this paper
• Apical sorting of a voltage- and Ca2+-activated K+ channel alpha -subunit in Madin-Darby canine kidney cells is independent of N-glycosylation.

  2000cites this paper
• Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization.

  2000cites this paper
• Mutations in sixth transmembrane domain of AQP2 inhibit its translocation induced by vasopression.

  2000cites this paper
• Interaction of alpha- and beta-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase beta-subunit.

  2000cites this paper
• Interaction of a- and b-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase b-subunit

  year unknowncites this paper