Determinants of Genetic Diversity of Spontaneous Drug Resistance in Bacteria

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Genetics

• Publication date

  2016-05-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1534/genetics.115.185355PMID 27182949PMCID PMC4937460
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Intratumor Heterogeneity in Evolutionary Models of Tumor Progression

  2011influential reference
• Estimating mutation rates in low-replication experiments.

  2011influential reference
• Initial Mutations Direct Alternative Pathways of Protein Evolution

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  2009influential reference
• Interplay in the Selection of Fluoroquinolone Resistance and Bacterial Fitness

  2009influential reference
• Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

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  2006influential reference
• The biological cost of mutational antibiotic resistance: any practical conclusions?

  2006cited by this paper
• Drug resistance in cancer: principles of emergence and prevention.

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• Interactions Among DNA Ligase I, the Flap Endonuclease and Proliferating Cell Nuclear Antigen in the Expansion and Contraction of CAG Repeat Tracts in Yeast

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  1978cited by this paper
• The sampling theory of selectively neutral alleles.

  1972cited by this paper
• The measurement of diversity in different types of biological collections

  1966cited by this paper
• Les mathématiques de l'hérédité

  1948cited by this paper
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  1948cited by this paper
• Mutations of Bacteria from Virus Sensitivity to Virus Resistance.

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